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Heart rate response and recovery in cycle exercise testing : normal values and association with mortality

Aims. Chronotropic incompetence and impaired heart rate (HR) recovery are related to mortality. Guidelines lack specific reference values for HR recovery. We defined normal values and studied blunted HR response and recovery and mortality risk. Methods and results. We included 9917 subjects (45% females) aged 18–85 years who performed a cycle exercise test. We defined normal values for peak HR, HR

Upper airway microbiome transplantation for patients with chronic rhinosinusitis

Background: Chronic or recurrent rhinosinusitis without polyps (CRSsNP) is characterized by a persistent inflammation of the sinonasal mucosa. The underlying cause is unclear but increasing interest has been directed toward changes in the sinonasal microbiome as a potential driver. Methods: Twenty-two patients diagnosed with CRSsNP were treated with antibiotics for 13 days, followed by 5 consecuti

A prospective observational study on persistent postoperative pediatric pain, 4P : The study protocol

BACKGROUND: Access to adequate pain treatment is a fundamental right, yet international data suggest that a considerable number of children experience acute and persistent pain. Little is known about the occurrence of both acute and persistent pain in children. The incidence of persistent postoperative pain in children is an unexplored area but international studies suggest that many children expe

eHealth in Pediatric Surgery : Impact on Postsurgical Care After Reconstructive Surgery for Anorectal Malformations and Hirschsprung's Disease

Background: To support care after discharge following surgery for anorectal malformations (ARM) and Hirschsprung's disease (HD), an eHealth device was invented, offering families bilateral communication through chat, photo, questionaries and video. Aim: To explore the impact of eHealth on postoperative patterns of expert consultation, complications and treatment after discharge following surgery f

Swedish national cohort of children living with long-term respiratory support (DISCOVERY-P) : cohort profile

Purpose Children living with respiratory support rely on medical technology, either fully or partially, throughout the day to meet their breathing requirements. Although children and young people living with respiratory support at home undergo long-term treatments and make extensive use of health and social care services, there is a notable absence of comprehensive outcome data on this group. The

pre-SUCCECS : Lessons learned from implementing resuscitation and stabilisation with an intact cord during caesarean sections – Focus group discussions with implementation teams

Objective: The primary aim of this study was to explore the lessons learned from implementing a procedure of resuscitation and stabilization with an intact umbilical cord for preterm and term infants requiring resuscitation or stabilization during emergency caesarean sections. Methods: Data were collected by two focus group discussions and one individual interview. Participants were members of imp

Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours

Introduction: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL t

Accuracy of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity score and the Nottingham risk score in hip fracture patients in Sweden — A prospective observational study

Background: Little is known about accuracy of common risk prediction scores in elderly patients suffering from hip fractures. The objective of this study was to investigate accuracy of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) score, Portsmouth-POSSUM (P-POSSUM) score and the Nottingham Hip Fracture Score (NHFS) for prediction of mortali

Network analysis of sea turtle movements and connectivity: A tool for conservation prioritization

Aim: Understanding the spatial ecology of animal movements is a critical element in conserving long-lived, highly mobile marine species. Analyzing networks developed from movements of six sea turtle species reveals marine connectivity and can help prioritize conservation efforts. Location: Global. Methods: We collated telemetry data from 1235 individuals and reviewed the literature to determine ou

Avian Behavioral and Physiological Responses to Challenging Thermal Environments and Extreme Weather Events

Birds occupy habitats ranging from Antarctic ice shelves and Arctic tundra to low-latitude deserts and lowland rainforests, and so are exposed to the full range of climates present on Earth. Cold, hot, or variable (on a variety of temporal scales) thermal conditions can present significant thermoregulatory challenges to birds, which typically must maintain body temperatures within narrow physiolog

Mechanical complications after central venous catheterisation in the ultrasound-guided era : a prospective multicentre cohort study

BACKGROUND: Limited data are available on the incidence of mechanical complications after ultrasound-guided central venous catheterisation. We aimed to determine the incidence of mechanical complications in hospitals where real-time ultrasound guidance is clinical practice for central venous access and to identify variables associated with mechanical complications.METHODS: All central venous cathe

The importance of time of day for magnetic body alignment in songbirds

Spontaneous magnetic alignment is the simplest known directional response to the geomagnetic field that animals perform. Magnetic alignment is not a goal directed response and its relevance in the context of orientation and navigation has received little attention. Migratory songbirds, long-standing model organisms for studying magnetosensation, have recently been reported to align their body with

Symptoms, problems and quality of life in patients newly diagnosed with oesophageal and gastric cancer - a comparative study of treatment strategy

BACKGROUND: Patients with oesophageal and gastric cancer have a low likelihood of being cured and suffer from a broad spectrum of symptoms and problems that negatively affect their quality-of-life (QOL). Although the majority (67-75%) of patients at the time of diagnosis suffer from an incurable disease, research has primarily focused on the pre- and postoperative phase among patients treated with

Prerequisites for Policy and Practice in School–University Partnerships in Sweden : Short- and Long-Term Incentives for Taking Responsibility

Teacher education for upper secondary school in Sweden is mainly university-based but with parts of the studies as school-based courses. To tackle the main obstacles to pre-service teachers’ placements, and to strengthen collaboration regarding quality and collaborative research, a new national policy is being implemented, which changes the prerequisites for collaboration between schools and unive

Enhancing Inclusive Crisis Planning: Insights from a Disability-Inclusive Scenario Workshop

In response to escalating disasters, inclusive crisis planning is crucial. This study examines a specialized workshop that engaged people with disabilities in crisis planning, focusing on a simulated flood scenario. Stakeholders from disability organizations and the local municipality collaborated, including eight crisis communicators and thirteen individuals with disabilities. The workshop facili

Generating Executable Test Scenarios from Autonomous Vehicle Disengagements using Natural Language Processing

With the emergence of autonomous vehicles comes requirements on adequate and rigorous testing techniques, particularly as systems continuously adapt to changing environments. Scenario-based, simulated testing is one approach that has received attention, where deriving relevant scenarios from various sources is still a challenge. We therefore explore creating executable test scenarios from textual

IsiXhosa Intellectual Traditions Digital Archive: Digitizing isiXhosa texts from 1870-1914

This article offers an overview of the IsiXhosa Intellectual Traditions Digital Archive, which hosts digitized texts and images of early isiXhosa newspapers and books from 1870-1914. The archive offers new opportunities for a range of research across multiple fields, and responds to debates around the importance of African intellectual traditions and their indigenous language sources in generating