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Background: A pattern of major and minor congenital anomalies, facial dysmorphic features, and neurodevelopmental difficulties, including cognitive and social impairments has been reported in some children exposed to sodium valproate (VPA) during pregnancy. Recognition of the increased risks of in utero exposure to VPA for congenital malformations, and for the neurodevelopmental effects in particu

Background: The optimal criteria to diagnose gestational diabetes mellitus (GDM) remain contested. The Swedish National Board of Health introduced the 2013 WHO criteria in 2015 as a recommendation for initiation of treatment for hyperglycaemia during pregnancy. With variation in GDM screening and diagnostic practice across the country, it was agreed that the shift to new guidelines should be in a

Purpose: Elevated cardiac troponin levels have been shown to be associated with a poor prognosis under some intensive care conditions. This study investigated whether inclusion of high-sensitivity troponin T (hsTnT) increased the prognostic accuracy of the Simplified Acute Physiology Score (SAPS 3) for general intensive care unit (ICU) patients, cardiac arrest patients, or patients with a non-card

Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts or routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants are eligible for the trial and to facilitate recruitment, to deliver an embedded intervention, to collect trial outcome data, or a combination of these purposes. This repor

Background: Diagnosing internal herniation (IH) in Roux-en-Y gastric bypass (RYGB) patients with acute abdominal pain poses a diagnostic challenge. Diagnostic laparoscopy is often required for a definitive diagnosis. We hypothesized that intestinal ischemia biomarkers would aid in the diagnosing of IH. Objectives: To explore intestinal ischemia biomarkers in diagnosing IH. Setting: University Hosp

We present an adaptive Discontinuous Galerkin discretization for the solution of porous media flow problems. The considered flows are immiscible and incompressible. The adaptive approach implemented allows for refinement/coarsening in both the element size and the polynomial degree. The method is evaluated using homogeneous and heterogeneous test cases.

Vi lever i en tid när gränsöverskridande rättsförhållanden blir en allt mer naturlig del av vår vardag. Med det ökade antalet internationella rättsförhållanden ökar också antalet potentiella tvister som har anknytning till mer än ett land. Makar med olika medborgarskap kanske kommer att vilja skiljas och den köpta produkten från det andra landet kanske var felaktig. När tvister av den här typen sk

The rise of online brand communities has transformed consumer/brand interactions, thus affecting consumer engagement and its nomological network. However, scholarly understanding regarding the effect of consumer values on their online engagement remains tenuous. Addressing this gap, we conceptualize a model that attempts to understand the relative effect of consumers’ values (terminal and instrume

The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted

Purpose: In this study, numerical simulations are performed to compare the adiabatic film cooling effectiveness and reveal the difference of film cooling mechanisms of two models with the same geometries and cross-section areas of film holes’ exits at three typical blowing ratios (M = 0.5, 1 and 1.5). The two models are an elliptical model and a cylindrical model with 90° compound angle, respectiv

Background: The power and influence of the hidden curriculum - culturally situated norms and values - onlearning opportunities is a growing concern in medical education. However, while medical schools producediversity and equal treatment policies, efforts towards surfacing and addressing equal opportunities in theclinical learning environment trail behind.Summary of Work: To better understand how

Human activities and climate change affect hydrological and sedimentological characteristics within catchments. For arid and semiarid areas this induces direct negative economic and environmental consequences on society. In fact, stability in the rainfall regime and less siltation trapped in reservoirs mean more water for irrigation, water supply, and better flood control. This is especially impor

Purpose: The fluid flow in a rotating channel is obviously different from that in a stationary channel due to the existence of Coriolis force, which, in turn, enhances the heat transfer on the trailing side and reduces the heat transfer on the leading side. The purpose of this paper is to study various rib configurations combined with channel orientation on heat transfer and frictional loss in a r

Purpose: This study aims to clarify the mechanism of film hole location at the span-wise direction of an internal cooling channel with crescent ribs on the adiabatic film cooling performance, three configurations are designed to observe the effects of the distance between the center of the ellipse and the side wall(Case 1, l = w/2, Case 2, l = w/3 and for Case 3, l = w/4). Design/methodology/appro