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Cancer genome sequencing has shed light on the underlying genetic aberrations that drive tumorigenesis. However, current sequencing-based strategies, which focus on a single tumor biopsy, fail to take into account intratumoral heterogeneity. To address this challenge and elucidate the evolutionary history of melanoma, we performed whole-exome and transcriptome sequencing of 41 multiple melanoma bi

Small (≤ 5 cm) soft tissue sarcomas (STS) of the extremities and the trunk wall generally have a favorable prognosis. However, 1 of 10 patients do develop metastases, and we therefore aimed to determine predictors of metastasis in a population-based cohort of patients with small STSs.

Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can

Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the stu

Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox regression [SCR], hazard ratios [HRs] with 95 % Confidence Intervals [CI]) in relatio

Whether cancer predisposing familial factors are associated with childhood tumors is unclear. The purpose was to study the incidence of childhood and adult tumors in extended families of children with cancer. Family history of cancer was obtained through questionnaires, and the Swedish Population-, and Cancer Registries for 194 childhood cancer patients aged ≤18 years, diagnosed 1972-2009. Standar

AIMS/HYPOTHESIS: Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin therapy. METHODS: We performed a retrospective study of 372 patients with LADA (205 men and 167 women; median age 54 years, range 35-80 years) from Swedish cohorts from Skåne (

ABSTACT: Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor speci

Cholecystokinin (CCK-) positive basket cells form a distinct class of inhibitory GABAergic interneurons, proposed to act as fine-tuning devices of hippocampal gamma-frequency (30-90 Hz) oscillations, which can convert into higher frequency seizure activity. Therefore, CCK-basket cells may play an important role in regulation of hyper-excitability and seizures in the hippocampus. In normal conditio

Currently there are no clinically recognized molecular biomarkers for malignant melanoma (MM) for either diagnosing disease stage or measuring response to therapy. The aim of this feasibility study was to develop targeted selected reaction monitoring (SRM) assays for identifying candidate protein biomarkers in metastatic melanoma tissue lysate. In a pilot study applying the SRM assay, the tissue e

Diversity between metastatic melanoma tumours in individual patients is known; however, the molecular and genetic differences remain unclear. To examine the molecular and genetic differences between metastatic tumours, we performed gene-expression profiling of 63 melanoma tumours obtained from 28 patients (two or three tumours/patient), followed by analysis of their mutational landscape, using tar

Although most ovarian cancers express estrogen (ER), progesterone (PR), and androgen (AR) receptors, they are currently not applied in clinical decision making. We explored the prognostic impact of sex steroid hormone receptor protein and mRNA expression on survival in epithelial ovarian cancer.

Popular Abstract in Swedish Denna avhandling syftar till att ge en översikt över cirka hundra år av europeisk intellektuell historia som lyfter fram nya aspekter av de klassiska tänkarna. Analysen av de fyra filosoferna Thomas Hobbes, John Locke, David Hume och Charles de Montesquieu syftar till att belysa en generell historisk process, nämligen hur den moderna människosynen växer fram i Europa. EThis essay has three main aims. The first one is to give an overview of some hundred years of European intellectual history, bringing out new aspects of the classical thinkers. The analysis of the four philosophers Thomas Hobbes, John Locke, David Hume and Charles de Montesquieu aims at illustrating a general historical process, viz. the emergence of the modern view of man in Europe. After Hobbes,

FÖRSÄTTSSIDA STYRDOKUMENT Riktlinjer vid misstanke om oredlighet i forskning som stöds av Public Health Services, USA Typ av styrdokument: Riktlinjer Definition av typen av styrdokument: Riktlinjer fastställer hur någon ska eller bör handla inom det område riktlinjerna omfattar. En ska- regel ska följas medan en bör-regel mer har karaktären av en stark rekommendation som innebär att man undantagsv

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2026-05/riktlinjer-vid-misstanke-om-oredlighet-i-forskning-som-stods-av-public-health-services-%20USA.pdf - 2026-06-07

Namnl.st-36 1 ORNIS SVECICA 9:1–10, 1999 Egg sizes of nine passerine bird species in a subalpine birch forest, Swedish Lapland Abstract ANDERS ENEMAR & OLA ARHEIMER Egg measurements together with calculated volumes are presented for nine passerine species (Prunella modularis, Luscinia svecica, Phoenicurus phoenicurus, Turdus pila- ris, Turdus philomelos, Turdus iliacus, Phylloscopus tro- chilus, F

https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-1211999enemarmflaggstorlek.pdf - 2026-06-07

Stakeholder Interaction in Research Processes A Guide for Researchers and Research Groups In many research projects, stakeholder interaction is ad hoc rather than strategic and systematic. This guide provides advice on good practice, strategies and tools for rese- archers and research groups interested in finding effective ways to involve stakehol- ders in their research and have an impact on soci

https://www.becc.lu.se/sites/becc.lu.se/files/guide_stakeholder_interaction_in_research_processes_revised_2019-06-05.pdf - 2026-06-07

Grön infrastruktur för bevarande av biologisk mångfald Grön infrastruktur för bevarande av biologisk mångfald BECC POLICY BRIEF | 07 · 2020 BECC POLICY BRIEF | 07 · 2020 Grön infrastruktur för bevarande av biologisk mångfald MARIA VON POST, Centrum för miljö- och klimatforskning, Lunds universitet JOHAN EKROOS, Centrum för miljö- och klimatforskning, Lunds universitet JOHANNA ALKAN OLSSON, Centrum

https://www.cec.lu.se/sites/cec.lu.se/files/gron_infrastruktur.pdf - 2026-06-07

56TH ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES Content Page EASD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Morgagni Prize . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

https://www.ludc.lu.se/sites/ludc.lu.se/files/easd2020_finalprogramme.pdf - 2026-06-07

China’s Mountains Regions’ Rural Development and Livelihood Improvement 1 China’s Mountain Regions: How to Maintain an Environmentally Sustainable Development While Improving Livelihoods? ---A Case Study of Yuanyang County, Yunnan Province, Southwest Part of China A thesis submitted in fulfillment of the requirement for the Degree of Master of Science Author: Na Guo Supervisor: Sara Brogaard nina2

https://www.lumes.lu.se/sites/lumes.lu.se/files/guo_na_thesis_2010.pdf - 2026-06-07