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Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods to 3,107 whole-genome-sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undescribed rearrangement signatures. We highlight interorgan variability of signatures and present a way

Aims: Ingrowth bags are widely used to estimate mycorrhizal growth and dynamics. However, it remains unclear to what extent they reflect the surrounding soil, and how this varies with environmental conditions. Methods: We used a fertilization experiment to investigate if carbon-free mesh bags were representative of their surrounding soil. We determined AMF hyphal length density (HLD), phospholipid

Despite a flurry of critical analyses discussing its controversial track record in terms of effectiveness and social feasibility, carbon offsetting remains one of the key mechanisms within global climate governance. We address an understudied dimension of the offsetting paradigm, with a focus on the voluntary carbon market and nature-based ‘solutions’, to inquire whether carbon trading constitutes

With the rapid development of blood biomarkers (BBMs) related to amyloid-β (Aβ) pathology in Alzheimer's disease (AD), the question arises whether these can replace the accepted reference standard, positron emission tomography (PET), for assessing Aβ burden. BBMs can differentiate Aβ status reliably in cognitively impaired patients, but two-threshold strategies to further improve their performance

Ecological network approaches have advanced our understanding of how species interactions influence community and evolutionary dynamics. However, a key limitation is that most network analyses rely solely on visitation data, often overlooking functional aspects of interactions. Here, we combined quantitative (visitation frequency) and qualitative (pollen removal and deposition) components to asses

Many plant invasions establish from only a few individuals and exhibit clonal spread, providing an opportunity to examine the genomic mechanisms that underlie the success of particularly aggressive individuals. One of the world’s most invasive species, the Japanese knotweed complex, is well suited for such investigations. Simultaneously developing ecological and genomics work in the native and int

Ouagadougou is a city with three million inhabitants and an increasing demand for water of sufficient quality. New boreholes are drilled to match demand, but their protection from anthropogenic contamination is insufficient. To assess the quality of urban groundwater in Ouagadougou for the first time, a total of 32 borehole water samples were collected and assessed for bacteriological and physicoc

Climate litigation has been on the rise since the beginning of the century. However, the increased use of intersectionality by plaintiffs to highlight their particular vulnerability to climate change and its impacts remains understudied. This paper provides a review of eleven intersectional climate litigation cases, along with insights from a focus group of key informants, to examine the role of i

Indigenous and Local Knowledge (ILK) is an expression of biocultural diversity and is vital for inclusive and sustainable forest management and epistemic justice. We examine how researchers studying tropical forest fauna engage with ILK and the Indigenous Peoples and Local Communities (IPLC) who are holders of this knowledge. We conducted a systematic review of 62 articles that focus on tropical f

Crises narratives surrounding the societal challenges of biodiversity loss, climate change, and human health and well-being dominate current debates in global environmental politics. These challenges are deeply interconnected and require transformative and integrated change. Marine and coastal Nature-based Solutions (blue NbS) are an opportunity to minimise harmful human impacts on these ecosystem

Insect diapause is a pre-programmed alternative developmental pathway induced to survive adverse environmental conditions and is characterized by an absence of development, metabolic suppression and increased stress resistance. While the hormonal regulation of diapause induction has been studied extensively, clear molecular hypotheses on how low-temperature driven diapause termination is controlle

Challengers struggle against more powerful elites and authorities to resolve environmental problems driven by social forces, but can sustainability research contribute to such collective action while remaining scientific? After five years of movement-relevant sustainability research using Burawoy’s extended case method, I seek to make three contributions. Empirically, I present strategic alliances

Using historical DNA (hDNA) from herbarium material, we reconstructed two centuries of population‐genetic change in the critically endangered Swedish field maple (Acer campestre). We genotyped 148 herbarium specimens collected from 1820 to 2020 with 12 nuclear microsatellite loci and plastid haplotypes, and compared them with contemporary Swedish and continental reference data. Expected heterozygo