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New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed
An increasing incidence of testicular cancer has been reported from several western countries during the last decades. According to current hypothesis testicular cancer is initiated during the foetal period and exposure to endocrine disruptors such as some persistent organic pollutants has been of concern. We have previously reported the results for concentrations of polychlorinated biphenyls (PCB
A non-associated plasticity theory for granular materials has been developed in Part 1 based on the concept of a characteristic stress state of vanishing incremental dilation. The model is fully three-dimensional and is defined by six material parameters: two for elastic stiffness, one for plastic stiffness, two for the shapes of yield and plastic potential surfaces and one for the dilation at fai
Empirical evaluations in software engineering are important in order to build a body of knowledge of methods that work in different environments. This thesis presents six empirical investigations of two techniques applied to software inspections, namely reading techniques and fault content estimation techniques. The first part of the thesis presents a series of experiments of a novel reading tech
Substitution of W for the Mo in M2-type Mo-V-Te-oxide was investigated. XRD, FTIR, XANES, and HRTEM verified that the substitution is possible in the whole range up to complete replacement of Mo by W. Catalytic measurements for propene ammoxidation show that both the specific activity and the selectivity to acrylonitrile pass through a maximum with increase of the W-content of the catalyst. XRD an
A reduction method is proposed for analysing structure-acoustic and poroelastic-acoustic problems within a finite element framework. This includes systems consisting of an acoustic fluid domain coupled to a flexible structural domain and/or a porous sound absorbing material domain. The studied problem is reduced by dividing the system into a number of physical subdomains. A set of basis vectors is
We present the FERRUM Project, an international collaboration aiming at a production and evaluation of oscillator strengths (transition probabilities) of selected spectral lines of singly ionized iron group elements, that are of astrophysical relevance. The results obtained include measurements and calculations of permitted and forbidden lines of Fe II. The data have been applied to both emission
The selective blockade of alpha1-adrenoceptors (ARs) is now a well-accepted and widely used treatment for patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and bladder outlet obstruction. The sites of action of the currently used alpha1-AR antagonists when relieving LUTS have not yet been established, but it seems clear that effects on
In order to evaluate the potential of cardiovascular tissue characterisation using near-infrared (NIR) spectroscopy, spectra in a previously unexplored wavelength region 0.8-2.3 mu m were recorded from various pig heart tissue samples in vitro: normal myocardium (with and without endo/epicardium), aorta; fatty and fibrous heart tissue. The spectra were analysed with principal component analysis (P
The environmental problems associated with office furniture consumption call for a more efficient use of office furniture that can decrease emissions and,volume of waste. The author discusses the opportunities and barriers for the implementation of a PSS for office furniture. In addition, the paper identifies possibilities to overcome these barriers. The article is based on interviews with Europea
The performance of a turbo code can be severely degraded if no trellis termination is employed. This paper investigates the implications of the choice of trellis termination method for turbo codes, and explains the origin of the performance degradation often experienced without trellis termination. An efficient method to derive the distance spectrum of turbo codes for different trellis termination
Popular Abstract in Swedish Denna avhandling undersöker dagvatten som en resurs i svensk urban miljö. Fokus har varit öppna dagvattensystem för flödeskontroll och uppsamlingssystem för regnvatten. För att analysera realiserandet av öppna dagvattensystem, presenteras två fallstudier; Augustenborg i Malmö och Bäckaslöv våtmark i Växjö. De kvarhållande och fördröjande effekterna som uppnås med gröna This thesis investigates the beneficial use of stormwater in Swedish urban environments. The focus has been on open stormwater systems for source control, as well as rainwater collection systems. To analyse the implementation of open stormwater systems, two case studies are presented: Augustenborg in Malmö and Bäckaslöv wetland in Växjö. The retention and detention effects of green-roofs have been
Postmenopausal decline of estrogen production is associated with development of several degenerative disorders such as osteoporosis, neuroinflammatory diseases and vascular wall degeneration. These are associated with the activation of the cells of the monocyte-macrophage system in a context-dependent manner. Estrogen regulates differentiation, maturation and function of many cell types in this sy
