Filetype
The limited available treatment options for patients with chronic lung diseases, such as fibrosis, lead to poor prognosis after diagnosis and short survival rates. An exciting new bioengineering approach utilizes de- and recellularization of lung tissue to potentially overcome donor organ shortage and immune reactions toward the received transplant. The goal of decellularization is to create a sca
Quantitative nuclear medicine imaging is an increasingly important frontier. In order to achieve quantitative imaging, various interactions of photons with matter have to be modeled and compensated. Although correction for photon attenuation has been addressed by including x-ray CT scans (accurate), correction for Compton scatter remains an open issue. The inclusion of scattered photons within the
Background The aim of the present study was to examine the outcomes and prognostic factors after surgery with curative intent for distal cholangiocarcinoma during a modern timespan, in a Swedish tertiary referral center. Methods All patients who underwent pancreaticoduodenectomy for distal cholangiocarcinoma between April 2008 and December 2015 were identified. Survival was estimated using the Kap
The increased impact from fluctuating energy sources like wind and photovoltaics significantly affects the operational regime of conventional power plants. In the near future, even former base load power plants such as the large-scale lignite plants in Germany will need to start and shut down to balance the electricity system. As frequent starts were not in the focus of optimisation in the past, a
MAX IV and SOLARIS are two synchrotron light sources located in Lund and in Krakow, respectively. A stripline is a standard multi-purpose component that is used in many accelerators and consists of one or multiple electrodes. The currents that are induced by the Lorentz contracted fields of the electron beam at the electrodes can be used for beam diagnostics, or one can excite the electrodes in or
Collaborative networks are widely employed as mechanisms to develop innovative responses in challenging environments. This approach has relevance in the area of regional development particularly where food production and tourism are two significant sectors underpinning regions. These two industries have conventionally operated as single sectors independent of each other. However, an inability to r
A method of diagnosing a disease that includes obtaining experimental data on gene selections. The gene selection functions to characterize a cancer when the expression of that gene selection is compared to the identical selection from a noncancerous cell or a different type of cancer cell. The invention also includes a method of targeting at least one product of a gene that includes administratio
Introduction: CD40 signaling activates dendritic cells leading to improved T cell priming against tumor antigens. CD40 agonism expands the tumor-specific T cell repertoire and has the potential to increase the fraction of patients that respond to established immunotherapies. Areas covered: This article reviews current as well as emerging CD40 agonist therapies with a focus on antibody-based therap
A bis(18-crown-6) Tröger's base receptor and 4-substituted hepta-1,7-diyl bisammonium salt ligands have been used as a model system to study the interactions between non-polar side chains of peptides and an aromatic cavity of a protein. NMR titrations and NOESY/ROESY NMR spectroscopy were used to analyze the discrimination of the ligands by the receptor based on the substituent of the ligand, both
Inequalities for S, P and D ππ partial waves are derived using crossing symmetry and positivity.
Mathematical modelling is an invaluable tool to describe dynamic cellular processes and to rationalise cell-to-cell variability within the population. This requires statistical methods to infer unknown model parameters from dynamic, multi-individual data accounting for heterogeneity caused by both intrinsic and extrinsic noise. Here we present PEPSDI, a scalable and flexible framework for Bayesian
Background: To compare effectiveness and safety of clopidogrel, prasugrel, and ticagrelor among all-comers with ST-segment elevation myocardial infarction (STEMI) and extend the knowledge from randomized clinical trials. Methods: All consecutive patients with STEMI admitted to Copenhagen University Hospital, Rigshospitalet, from 2009 to 2016 were identified via the Eastern Danish Heart Registry. B
A common library, TMDlib2, for Transverse-Momentum-Dependent distributions (TMDs) and unintegrated parton distributions (uPDFs) is described, which allows for easy access of commonly used TMDs and uPDFs, providing a three-dimensional (3D) picture of the partonic structure of hadrons. The tool TMDplotter allows for web-based plotting of distributions implemented in TMDlib2, together with collinear
Crowe-McAuliffe et al. present cryo-EM structures of native ribosome-associated quality control complexes from Bacillus subtilis, revealing how RqcH cooperates with RqcP/YabO to mediate protein synthesis on the large 50S subunit in the absence of the translocase EF-G, mRNA, and the small 30S subunit.
For the past 30 to 40 years, well before the concept of sustainable development became politically correct, regulation of the environment has been covered by Environmental Protection Agencies worldwide. Perhaps one of the most important things that we have learned is that regulations have significant costs, not just benefits, and that analysis of the cost and benefit of proposed rules is an indisp
Acute as well as chronic pain syndromes are common after whiplash trauma and exercise therapy is proposed as one possible intervention strategy. The aim of the present systematic review was to evaluate the effect of exercise therapy in patients with Whiplash-Associated Disorders for the improvement of neck pain and neck disability, compared with other therapeutic interventions, placebo interventio
Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, t
nterspecific hybridization had been long recognized as a widespread evolutionary process in vascular plants. In the present review, we summarize knowledge concerning studies of interspecific hybridization in bryophytes before and after the advent of molecular methods. The available data indicate that hybridization is an important evolutionary phenomenon among bryophytes. evidence fo
