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Modern radiotherapy aims to treat the decease while minimizing the radiation dose to the adjacent normal tissue, to minimize acute and late effects of the treatment. The foremost technological approaches have been intensity modulated radiotherapy (IMRT) and intensity modulated proton therapy (IMPT) in combination with image guided radiotherapy (IGRT). IMRT and IMPT is characterized by a more confo
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated the function of laminin γ1 chain in heart, lung and other tissues by generating a mouse that lacks laminin γ1 in cells expressing SM22α (Tagln) (LMγ1 flox/SM22α C
We prove that polynomial calculus (and hence also Nullstellensatz) over any field requires linear degree to refute that sparse random regular graphs, as well as sparse Erdős-Rényi random graphs, are 3-colourable.
This paper reports the interim results of an ongoing systematic review of the available evidence for the effectiveness of nursing care for people with Parkinson's disease (PD). Five clinical and four health-economic evaluations suggest that the clinical and cost effectiveness of nursing care for PD remain inconclusive. This is in contrast to clinical experience and may be due to issues related to
Background Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. The lac operon of E. coli is but one example of how enzyme and transporter production can be made conditional on the presence of a nutrient to catabolize. Methodology With a minimalist model of metabolism, cell growth and transcriptional regula
Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal proteins and immediate early genes in different cell types. Here, we found that SRF expression is restricted to endothelial cells (ECs) of small vessels such as capillaries in the mouse embryo. EC-specific Srf deletion led to aneurysms and hemorrhages from 11.5 days of mouse development (E11.5) and l
RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Furthermore, the differentiation and expansion of DN3 and DN4 thymocytes in vitro were severely impaired. These defects corresponded to defective T
The tendency to buy expensive and unnecessary goods is a pattern of consumer behavior that is becoming all too common in our society. We consume luxury items to satisfy practical needs that are already satisfied in the quest toward self-fulfillment, or simply to impress those around us. The phenomenon of “status consumption” has become increasingly evident in modern society. Although conspicuous c
With two centuries of forestry, natural forests in boreal Sweden are rare and strongly fragmented. Hence, restoration aiming to improve conditions for forest biodiversity is needed. However, to ensure landscape connectivity – where to restore is a critical concern.Our study objective was to identify connectivity forest that through restoration support connectivity and biodiversity. The study area
Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl
MILJÖVETENSKAP Planering/schema 180831 Kurs: MVEN03 - Miljövetenskap: Analys och metodik, 15 hp HT 2018 Kursansvarig: Nina Reistad NR nina.reistad@fysik.lth.se Lärare: Estelle Larsson EL estelle.larsson@med.lu.se Christian Lindh CL christian.lindh@med.lu.se Per Erik Isberg PEI per-erik.isberg@stat.lu.se Pål Axel Olsson PAO pal_axel.olsson@biol.lu.se Martijn van Praagh MVP martijn.van_praagh@mv.lu.
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven03_planering_ht18_180831.pdf - 2026-07-10
MILJÖVETENSKAP Preliminär planering/schema 180829 Kurs: MVEN03 - Miljövetenskap: Analys och metodik, 15 hp HT 2018 Kursansvarig: Nina Reistad NR nina.reistad@fysik.lth.se Lärare: Estelle Larsson EL estelle.larsson@med.lu.se Christian Lindh CL christian.lindh@med.lu.se Per Erik Isberg PEI per-erik.isberg@stat.lu.se Pål Axel Olsson PAO pal_axel.olsson@biol.lu.se Martijn van Praagh MVP martijn.van_pr
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven03_planering_ht18_180829.pdf - 2026-07-10
MILJÖVETENSKAP Preliminär planering/schema 180830 Kurs: MVEN03 - Miljövetenskap: Analys och metodik, 15 hp HT 2018 Kursansvarig: Nina Reistad NR nina.reistad@fysik.lth.se Lärare: Estelle Larsson EL estelle.larsson@med.lu.se Christian Lindh CL christian.lindh@med.lu.se Per Erik Isberg PEI per-erik.isberg@stat.lu.se Pål Axel Olsson PAO pal_axel.olsson@biol.lu.se Martijn van Praagh MVP martijn.van_pr
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven03_planering_ht18_180830.pdf - 2026-07-10
