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BACKGROUND: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With few exceptions, detailed studies on second generation sulphonylureas in diabetics with impaired renal function are lacking.

AbstractRecent research in the wider archaeological landscape of Great Zimbabwe recovered moreevidence of metallurgical tuyeres fused in varied multiples indicative of their use in natural draft iron smelting technologies. We report the first detailed chemical, microstructural and thermal analyses of these ceramic materials most likely associated with large-scale iron production at the zenith of tWe report the first detailed chemical, microstructural and thermal analyses of a growing corpus of metallurgical tuyeres from the wider archaeological landscape of Great Zimbabwe in southern Africa. Of note is the fusion of the tuyeres in multiples, suggestive of widespread use of natural draft iron smelting technologies for large-scale production of iron most likely during the zenith period of Gr

Due to their natural and inherent way of capturing concurrency, dataflow descriptions of stream programs have seen prevalent usage in fields such as video processing, networks and scientific computing. They are often deployed on manycore, heterogeneous and distributed architectures. Despite robust research on the topic, obstacles still exist in evaluating the performance of stream programs accurat

Background: Employment is a vital source for experiencing well-being and lowering the risk of long-term social marginalisation and poverty. For persons with alcohol and drug addiction, it may also improve sobriety. However, the unemployment situation for this group reflects the knowledge gap in effective interventions to support employment. While Individual Placement and Support (IPS) is recognise

In a world where copyright is being infringed in a plethora of ways, consumers find it difficult to access legal digital content. Therefore, this thesis investigates how copyright law governs access to legal content in the digital environment in respect of so-called consumptive use. By apprehending a user-centric approach I evaluate whether and how copyright law accounts for the consumer interest

Purpose: Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurrent and longitudinal tau PET with longitudinal changes in atrophy and relative CBF. Methods: We included 61 individuals from the Amsterdam Dementia Cohor

Currently, most clinical range-modulated proton beams are assumed to have a fixed overall relative biological effectiveness (RBE) of 1.1. However, it is well known that the RBE increases with depth in the spread-out Bragg peak (SOBP) and becomes about 10% higher than mid-SOBP RBE at 2 mm from the distal edge (Paganetti 2003 Technol. Cancer Res. Treat. 2 413-26) and can reach values of 1.3-1.4 in v

BACKGROUND: Hemostatic disorders are common in obstetric complications. Thromboelastography (TEG (R)) simultaneously measures coagulation and fibrinolysis within 10 to 20 minutes. Our primary aim in this prospective longitudinal study was to obtain knowledge about physiological changes in TEG (R) variables during normal pregnancy and 8 weeks postpartum. The secondary aims were to compare TEG (R) v

Lentic water bodies (lakes and reservoirs) offer favorable conditions for silica (SiO2) burial in sediments. Recent global estimates suggest that (1) lentic SiO2 trapping is a globally important SiO2 flux, and (2) through reservoir construction, humans have dramatically altered river dissolved SiO2 (DSi) transport and coastal DSi delivery. However, regional to global scale patterns and controls of

Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female)

The rs738409 C > G single-nucleotide polymorphism in PNPLA3 leads to a missense mutation (I148M) which increases liver fat but does not cause insulin resistance. We hypothesised that patients with non-alcoholic fatty liver disease (NAFLD) due to the PNPLA3 variant ('PNPLA3 NAFLD'aEuro parts per thousand= PNPLA3-148MM) do not have adipose tissue (AT) inflammation in contrast with those with NAFLD d

The development of real-time ultrasound in the 1970's made indelible inpact on antenatal care. Assessing foetal growth and detecting deviations from normal in both growth and foetal anatomy became fesible. Expectant parents could also 'see' their foetus. Normal foetal growth parameters at term were consituted and selected parameters from the second trimester were evaluated in the detection of chro

AIMS/HYPOTHESIS: Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diab

Idag är kommunikation, marknadsföring och transaktion av produkter nyckelfunktioner för produktförpackningar. Kvaliteten på det grafiska förpackningstrycket är därför av stor betydelse och måste vara konsekvent för stora produktionskvantiteter. En av de vanligaste tryckteknikerna för tryck på papper eller kartong är flexografiskt tryck. Med denna teknik appliceras färger en efter en och genom deraToday communication, promotion and transaction of products are key functions of product packaging. The quality of the package print is therefore of great importance and needs to be consistent for large production quantities. One of the most common technologies for printing on paper or cardboard is flexographic printing. With this technology colors are applied one by one and through their combinati

Sammanfattning Vi har gjort en kvalitativ studie och intervjuat individer med en tidigare missbruksproblematik och kriminellbakgrund. Alla utom en av intervjupersonerna har deltagit i ett 12-stegsprogram. Det finns hjälp att få som missbrukare genom behandling, men det är ändå inte alla som klarar av att sluta fast den hjälpen finns. Det är viktigt och intressant att undersöka varför det är så. VWe have made a qualitative study that started from interviewees with substance abuse problems. All of the interviewees have a background as criminals and addicts and three of them have participated in twelve-step program. There is treatment that is intended to support and help addicts, but it's still not all that manage to get out of their addiction. That makes it important and interesting to

The objective of this chapter is to contribute to the understanding of the growth of this global data-driven market ecology, mainly in order to pinpoint important regulatory challenges, where individual choice and agency, as well as competition, seem undermined. Truly, this development holds many promises for new innovation, some more disruptive than others, but also poses challenges that in this

In this study, we analyzed healthcare provision and health expenditure across six Mediterranean countries that adopt the National Health System (Beveridge model) and that form part of the European Union (EU) with the main aim being that of analyzing and comparing out-of-pocket health spending in countries with a European Mediterranean connection. To this end, we considered various economic indicat

Background: OncoMasTR is a new multigene prognostic test that was discovered via a novel transcriptional network analysis method that identified upstream Master Transcription Regulators (MTRs), which regulate previously identified prognostic biomarkers. The optimised OncoMasTR signature incorporating clinicopathological information has been shown to be significantly prognostic for predicting dista

Nitrogen (N) availability is a powerful controller of soil carbon (C) cycling in temperate forests, affecting plant productivity and microbial activities. Enhanced rhizosphere input from increased plant productivity can stimulate the decomposition of native soil organic matter (SOM), termed the “priming effect”, with an effect size that is affected by N availability. Using soils from N-fertilizati

As interest in the processes of integration of immigrants and ethnic minorities grows among European scholars, the role of multiple actors in shaping civic and political participation by people of migrant background needs to be further examined. Building on the literature on migration, this study addresses the following research question: What accounts for differences in forms of civic and politic