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To identify from a patient's perspective, difficulties and differences in the comprehension of five global presenteeism measures in patients with inflammatory arthritis and OA across seven countries.

ABSTRACT: Study Design. Prospective randomized controlled study.Objective. To compare the outcome of indirect decompression by means of the X-Stop implant to conventional decompression in patients with neurogenic intermittent claudication due to lumbar spinal stenosis.Summary of Background Data. Decompression is the golden standard for lumbar spinal stenosis nowadays but afflicted with complicatio

There is little consensus on the optimal components of gambling psychological treatments. This study aimed to identify clinical consensus statements regarding the perceived effectiveness of gambling intervention content (change techniques, participant/recruitment characteristics, delivery characteristics, and evaluation characteristics) from a panel of researchers with psychological gambling treat

Aims To explore the prevalence and incidence of paediatric implantable cardioverter-defibrillator (ICD) patients in Sweden and identify risk factors associated with appropriate shocks and adverse events. Methods and results We performed a nationwide, retrospective cohort study of ICD use in paediatric patients (<19 years) between 1995 and 2017; 120 patients underwent ICD implantation at median age

The Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to utilize deep neural networks, sacrificing its explainability. In this work, we explore the potential of self-explaining neural networks (SENN) for survival analysis. We propose a new locally explainable

Antipsychotic drugs (APD) are commonly prescribed to people living with dementia (PwD) to manage behavioral and psychological symptoms of dementia (BPSD), despite well-documented safety concerns. International guidelines recommend non-pharmacological interventions as first-line treatment, yet APDs remain widely used. This systematic review and meta-analysis synthesize current evidence on the conse

OBJECTIVE: Fatigue is a common and debilitating non-motor symptom of Parkinson's disease (PD), arising from a complex interplaying underlying factors. While mental health and sleep are well-established evidence regarding motor symptoms, balance, gait, and cognition remain inconsistent. By explicitly examining multiple symptom domains within the same cohort, we aimed to identify which factors are m

Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experi

Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. Gene therapy has been suggested to be a promising approach to target drug-resistant focal epilepsy si

Background: Crohn disease and biliary diseases have been associated with small-bowel adenocarcinoma (SBA). We examined how medical conditions affect the risk of SBA. Methods: A population-based European multicentre case-control study during the period 1995-97 including 95 histologically verified cases of SBA along with 3335 population controls; 70 cases (74%) and 2070 (62%) controls were interview

By giving a brief overview of the metaconcepts in nursing, with a focus on environment, we sketch a theoretical framework for an emancipatory perspective in nursing care practice. To meet the requirements of equality in care and treatment, we have in our theoretical framework added a critical lifeworld perspective to the antioppressive practice, to meet requirements of equity in health care encoun

Over the past decade, the healthcare industries have been facing the issue of resource scarcity due to socio-political wars, the COVID-19 pandemic, the luxury lifestyles of people, and the prevalence of single-use medical devices. The circular economy (CE) can be vital in accommodating the evolving patient and provider demands. The CE defies the conventional take-make-dispose process and advocates

While the Convention on the Rights of the Child (UNCRC) does not address research, it instigated a recognition that decisions concerning children and youth must be based on knowledge of their experiences from their own perspective and consider their specific views and wishes, highlighting their right to be heard. Participatory research underscores this right, arguing the engagement of children and

The distinguishing feature of frequency diverse array (FDA) systems as compared to conventional phased-array and multiple-input multiple-output (MIMO) radar systems is the use of a small frequency offset (FO) across the array elements. Much of the development to date has focused on the FDA-MIMO structure, using an FO that is larger than the bandwidth of the baseband signal, thereby reducing the re

In this research, we develop three statistical based control charts: the Hotelling's T2, MEWMA (multivariate exponentially weighted moving average), and LRT (likelihood ratio test) as well as three machine learning (ML) based control charts: the ANN (artificial neural network), SVR (support vector regression), and RFR (random forest regression), for monitoring generalized linear model (GLM) profil

Idag lever allt fler människor under förhållanden som definieras som prekära. Även i avancerade välfärdssamhällen lyckas inte de traditionella trygghetssystemen erkänna och hantera de nya sociala risker som dessa grupper inom ”prekariatet” ställs inför. Bland dessa grupper finner vi migrantkvinnor med osäker rättslig ställning. Denna forskning undersöker hur aktörer i akademin och i civilsamhälletIn advanced welfare societies, traditional welfare programs are failing to recognize and respond to new social risks faced by groups in precarious life situations, including migrant women. This research explore how actors in academic and civil society settings recognize and frame the struggles of migrant women with precarious legal status, particularly in terms of gender-based violence (GBV) and a

Bovine α-lactalbumin (BLA) forms cytotoxic complexes with oleic acid (OA) that perturbs tumor cell membranes, but molecular determinants of these membrane-interactions remain poorly understood. Here, we aim to obtain molecular insights into the interaction of BLA/BLA-OA complex with model membranes. We characterized the folding state of BLA-OA complex using tryptophan fluorescence and resolved res

In certain sensory neurons of many different invertebrate species, including the sea anemones. Metridium senile and Tealia felina and the crustacean Anemia salina, fluorophores are formed during the course of the fluorescent histochemical technique of Falck-Hillarp. The presumed catecholamine nature of the neuronal fluorogenic compound was investigated by microspectrofluorometry, and the spectral In certain sensory neurons of many different invertebrate species, including the sea anemones. Metridium senile and Tealia felina and the crustacean Anemia salina, fluorophores are formed during the course of the fluorescent histochemical technique of Falck-Hillarp. The presumed catecholamine nature of the neuronal fluorogenic compound was investigated by microspectrofluorometry, and the spectral