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Protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry(1), yet there are no mucosal adjuvant formulations licensed for human use. Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo(2,3). Here we show that diverse PEI forms have potent m
In osteoblasts, cyclooxygenase 2 (COX-2) is the major isozyme responsible for production of prostaglandins. Prostaglandins are local mediators of bone resorption and formation and are known to be involved in bone's adaptive response to fluid shear stress (FSS). We have previously described a model of trabecular bone loss in hindlimb-suspended mice and rats and demonstrated partial protection from
Gwadar port is a deep-sea port that lies at the southwestern coast of the Balochistan province. Since 2002, it has been given quite some attention; the government realized its potential of becoming a major hub port of the region, given its proximity to the Strait of Hormuz, a sea passage through which a fifth of the world’s oil transit occurs. MOUs have been signed and commitments made in excess o
The lytic polysaccharide monooxygenase (LPMO) enzymes boost polysaccharide depolymerization through oxidative chemistry, which has fueled the hope for more energy-efficient production of biofuel. We have recently proposed a mechanism for the oxidation of the polysaccharide substrate (E. D. Hedegård and U. Ryde, Chem. Sci., 2018, 9, 3866-3880). In this mechanism, intermediates with superoxide, oxyl
Våren 2000 enades Europeiska Rådet om att senast år 2010 ha förvandlat Europa till världens mest konkurrenskraftiga kunskapsbaserade ekonomi. Riktlinjerna samlades i den s.k. Lissabonstrategin. Genom att kritiskt granska dokument som producerats inom ramen för Kommissionens agenda i2010: "Ett informationssamhälle för tillväxt och konkurrens" vill jag synliggöra hur EU beskriver informat
Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is
1.Among small animals dispersal parameters are mainly obtained by traditional methods using population studies of marked individuals. Dispersal studies may underestimate the rate and distance of dispersal, and be biased because of aggregated habitat patches and a small study area. The probability of observing long distance dispersal events decreases with distance travelled by the organisms. In thi
BACKGROUND: The aim of the study was to determine the role of Vascular Endothelial Growth Factor (VEGF) on the microvasculature and on angiogenetic gene expression after partial hepatectomy (PH) in the rat model.METHODS: To determine the effect of exogenous and endogenous VEGF after PH, rats were subjected to 70% PH and treated either with VEGF, anti-VEGF or NaCl. Postoperatively (3-168 h), vessel
Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results: In two cohorts of primary breast cancers, PKC alpha levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKC delta a
Thesis purpose: The purpose is to enhance the understanding of the influence inclusion has on Generation Y consumers when utilised in fashion brands. By isolating two areas of interest namely marginalised gender and size, we aim to provide insight into their effects on the attitude and purchase intention. Methodology: A deductive approach and therefore a quantitative research design is chosen. T
Constitutional monarchy offers Iran a politically stable and culturally resonant alternative to partisan republicanism. Grounded in both empirical research and philosophical tradition, it combines symbolic authority with institutional continuity, enabling national unity without authoritarianism. Monarchs function as neutral anchors above political conflict, often at lower public cost and with grea
Cloud RAN (C-RAN) is a promising paradigm for the next generation radio access network infrastructure, which offers centralised and coordinated base-band signal processing in a cloud-based BBU pool. This requires extremely low latency responses to achieve real-time signal processing. In this paper, we analysed the challenges to introduce cloud native model for signal processing in C-RAN. We studie
It is likely that everyone will, at some time, suffer from a problem related to the musculoskeletal system, ranging from a very common problem such as osteoarthritis or back pain to severely disabling limb trauma or rheumatoid arthritis. Many musculoskeletal problems are chronic conditions. The most common symptoms are pain and disability, with an impact not only on individuals’ quality of life bu
tRNA is the adaptor in the translation process. The ribosome has three sites for tRNA, the: A-, P-, and E-sites. The tRNAs bridge between the ribosomal subunits with the decoding site and the mRNA on the small or 30S subunit and the peptidyl transfer site on the large or 50S subunit. The possibility that, translation release factors could mimic tRNA has been discussed for a long time, since their
