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Audio description (AD) serves a critical role in making audio-visual media accessible to visually impaired audiences, aiming to enhance their viewing experience and comprehension (Holsanova 2016, 2022). A central inquiry in the context of successful AD pertains to how the sequence of events unfolding in a film aligns with the verbal narration conveyed through AD (Vandaele 2012). Accumulating resea
Popular Abstract in Swedish Movimiento al Socialismo (MAS) bildade regering i Bolivia 2006 med Evo Morales på presidentposten, framburna av folkliga protester mot tidigare, nyliberala regimer. Morales beskrivs ofta som landets första president med bakgrund i ursprungsbefolkningen. Hans regering utlovade en radikal omställning av den nationella politiken och tillkännagav att Bolivia nu är en "pluriEvo Morales and the Movimiento al Socialismo (MAS) took office in Bolivia in 2006, riding on the wave of fierce popular protests against previous, neoliberal regimes. Morales was depicted as the country’s first indigenous president. His government promised a radical transformation of national politics and rebranded Bolivia as a “plurinational state”. Under MAS, indigenous subjectivity has moved fr
Motor complications impair quality of life and cause severe disability in patients with advanced Parkinson's disease (PD). Since they are often refractory to medical therapy, interventional therapies have been developed, which can provide a considerable reduction of daily off-time and dopaminergic dyskinesias. Continuous dopaminergic drug delivery (CDD) is based on the steady stimulation of striat
PI3-kinase has a crucial role in transformation mediated by the oncogenic c-Kit mutant D816V. In this study, we demonstrate that the c-Kit/D816V-mediated cell survival is dependent on an intact direct binding of PI3-kinase to c-Kit. However, mutation of this binding site had little effect on the PI3-kinase activity in the cells, suggesting that c-Kit/D816V-mediated cell survival is dependent on PI
The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1
Many studies have tried to explain the stock market value premium identified by Fama and French and Rosenberg, Reid and Lanstein. To the proponents of conventional asset pricing theory the value premium, measured by HmL (high book-to-market minus low book-to-market), is a bit of a dilemma. This is due to that the value of growth stocks depend more on business cycles than on value stocks, whose val
This thesis focus on how notions of equality and neo-liberal pursuits for growth are negotiated in policy, discussing the relationship between problem definition at top level and the implemented solution at policy level. The problem is defined in the European Union’s growth strategy Europe 2020 as Europe having to increase productivity, while the implemented solution I focus on is the emerging foc
Inherited resistance to activated protein C (APC) was recently discovered to be a cause of familial thrombophilia and is now known to be the most common genetic risk factor for venous thrombosis. It is caused by a single point mutation in the gene for factor V, which predicts substitution or arginine (R) at position 506 with a glutamine (Q). Accordingly, the activated form of mutated factor V (FVa
BACKGROUND: As recently pinpointed by a genome-wide association study the serine/threonine kinase 39 (STK39) is a candidate gene for hypertension. This kinase is strongly implicated in sodium reabsorption by the kidney through its modulating effect on furosemide-sensitive and thiazide-sensitive channels. The aim of our study was to test the effects of the STK39 rs35929607A>G polymorphism on blood
Alloreactive memory T cells are major barriers to transplantation acceptance due to their capacity to accelerate rejection. Here, we investigated the effects of combined treatment with arsenic trioxide (As(2)O(3)) and blocking monoclonal antibodies (mAb) against CD154 and LFA-1 (anti-CD154/LFA-1) on graft survival as well as changes in pathology and immunological responses in mice with adoptively
CD40 is a tumour necrosis factor receptor (TNFR) family member of central importance for the adaptive immune system. To elucidate the functional role of the different extracellular domains of CD40, we have created a set of truncated CD40 molecules where domains, or parts of domains, have been removed. These CD40 proteins, which contain a peptide tag in the N-terminal end, have been expressed in a
In this study, aldehyde dehydrogenase 1 (ALDH1)-expressing cells in stroma of histologically normal breast tissue from premenopausal women were investigated in situ regarding cellular morphology, cell distribution, and relation to the additional stem cell markers, CD44 (+) and CD24 (-). These results were correlated with hormonal and genetic risk factors for breast cancer. Triple immunofluorescenc
Candida antarctica lipase B (CALB) and Thermomyces lanuginosa lipase (TLL) were evaluated as catalysts in different reaction media using hydrolysis of tributyrin as model reaction. In o/w emulsions, the enzymes were used in the free form and for use in monophasic organic media, the lipases were adsorbed on porous polypropylene (Accurel EP-100). In monophasic organic media, the highest specific act
Particle emissions from residential wood combustion in small communities in Northern Sweden can sometimes increase the ambient particle concentrations to levels comparable to densely trafficked streets in the center of large cities. The reason for this is the combination of increased need for domestic heating during periods of low temperatures, leading to higher emission rates, and stable meteorol
Alkyl glycosides are surfactants with good biodegradability and low toxicity, attractive to produce by an enzymatic method to get a well-defined product. In this paper, we report a novel thermostable variant of a family 3 β-glucosidase to be an efficient catalyst in alkyl-glucoside forming reactions using transglycosylation with hexanol or octanol as the acceptor molecule. The enzyme has an appare
Although there is a high degree of homology in the M2 transmembrane segments of alpha1 and beta1 subunits, subunit-specific effects were observed in alpha1beta1 GABA(A) receptors expressed in Spodoptera frugipedra (Sf9) cells when the conserved 13' threonine residue in the M2 transmembrane region was mutated to alanine. When threonine 263 (13') was mutated to alanine in the beta1 subunit, high-aff
Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phan
The purpose of this thesis is to develop knowledge about visual information seeking and how it might be affected by socio-technical circumstances, with its focus on GeoGuessr players’ research through Google Street View. The study asks two research questions: 1. How do GeoGuessr players use Google Street View to do research? and 2. How can Google Street View’s socio-technical circumstances affect
