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We present an advanced approach for single-cell analysis of circulating tumor cells (CTCs) by integrating an acoustofluidic chip for sample preparation, including simultaneous acoustophoretic separation and enrichment of the separated cells, onto an electroactive microwell array (EMA) for single-cell arraying. The integrated device shows highly efficient cell recovery of target cells (82.5%) and d
The debate about post-2012 global climate governance has been framed largely by proponents and opponents of the policymaking process established by the United Nations Framework Convention on Climate Change (UNFCCC). In light of the proliferation of institutions governing some aspects of climate change, analysts have asked whether a centralized or a polycentric climate governance architecture will
Den 13 november 1872 inträffade en extrem översvämning i kustområdena kring Södra Östersjön. Högt vattenstånd i kombination med höga vågor ledde till att cirka 300 personer omkom och fler än 15 000 blev hemlösa. Utmed Skånes kust omkom minst 23 personer, över 100 bostadshus förstördes och hundratals kustfiskare förlorade sin inkomstkälla då båtar och fiskeredskap slogs sönder och drogs ut i havet.On November 13, 1872 an extreme flood occurred in the coastal areas surrounding the South Baltic Sea. An extreme storm surge in combination with high waves caused the death of about 300 people and more than 15,000 people lost their homes. Along the coast of Scania, southern Sweden, at least 23 people were killed and more than 100 houses were destroyed. Hundreds of fishermen lost their source of in
This paper is part of my ongoing doctoral research centered on “Street Art and Cognitive Semiotics: The case of Athens” at the division of Cognitive Semiotics at Lund University. More concretely, in this article, a fresh approach, based on a constructive (verbo-) pictorial argument, is taken to attending the relationship between a cognitive semiotics approach and street art signs in a programmatic
Aim High quality evidence of out-of-hospital cardiac arrest (OHCA) survivors’ health-related quality of life (HRQoL) can measure the long-term impact of CA. The aim of this study was to critically appraise the evidence of psychometric quality and acceptability of measures used in the assessment of HRQoL in cardiac arrest survivors. Methods Systematic literature searches (2004–2017) and named autho
The transcription factor ZNF224 plays a key proapoptotic role in chronic myelogenous leukemia (CML), by modulating Wilms Tumor protein 1 (WT1) dependent apoptotic genes transcription. Recently, we demonstrated that Bcr-Abl signaling represses ZNF224 expression in Bcr-Abl positive CML cell lines and in CML patients. Interestingly, Imatinib and second-generation tyrosine kinase inhibitors specifical
Self-adaptive software systems monitor their operation and adapt when their requirements fail due to unexpected phenomena in their environment. This paper examines the case where the environment changes dynamically over time and the chosen adaptation has to take into account such changes. In control theory, this type of adaptation is known as Model Predictive Control and comes with a well-develope
Problemformulering: Byggprocessen är idag långsam, kostsam och genererar stora mängder spill och utsläpp. För att kunna möta bostadsbehovet från den snabbt växande befolkningsmängden måste tekniken utvecklas, den måste bli snabbare och mer kostnadseffektiv. Med ny teknik där betongelement tillverkas genom automatiserad och datorstyrd 3D-printning kan eventuellt hela betongbyggnadsprocessen effektiQuestion formulation: The construction process today is slow, costly and generates large amounts of waste and emissions. In order to meet housing needs of the rapidly growing population in a sustainable way, the technology must evolve; it must be faster and more cost-effective. New technology, where concrete is manufactured by automated and computer-controlled 3D-printing, can possibly streamline
The main purpose of this study is to investigate how members of staff at group homes (LSS-bostäder) reason about the service users’ rights to self-determination in everyday life. Additionally, this study aims to investigate how group homes as a place may affect the fulfillment of self-determination rights. The following theories “The theory of Recognition” and ”the Principle of normalization”, the
This study investigates the potential of large language models (LLMs), such as ChatGPT, to aid venture capitalists in the screening of startups that maximize sustainability impact. To determine the scope that maximizes impact for venture capitalists' and to identify effective screening criteria, the study utilized theoretical research and interviews. The thesis suggests that the ideal investme
In this work we present theoretical modeling and additional experiments to characterize noncontact acoustic trapping in a small glass capillary. We provide numerical 3D-simulations that captures several key features of the experiment.
Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. But the genetic component of the disease, as well as enhanced vulnerability of the midbrain dopaminergic neurons of the Substantia
Accurate prediction of groundwater levels (GWL) is essential for effective and sustainable water resource management, particularly in arid and semiarid regions where excessive extraction and climate change significantly accelerate aquifer depletion. The nonstationary characteristics of groundwater data pose significant challenges to the performance and reliability of conventional machine learning
Purpose: Preeclampsia is a serious pregnancy complication without curative treatment. The central nervous system (CNS) is affected in severe cases of preeclampsia. Until now, no biomarker or other predictive method has been established for predicting severe CNS injury, including the development of eclampsia and/or long-term complications. In this systematic review, we aimed to investigate the asso
Background: In clinic, a subjective visual estimation of a patient’s general health often guides interventions, yet little is known of how this assessment relates to objectively measured frailty. Aims: To characterize the relationship between these two assessments and explore the implication of discordance. Methods: The study was performed in the OPRA cohort of 75-year old community-dwelling women
With the trend of transport electrification, the fleet of delivery and transport vehicles with internal combustion engines taking fossil fuel in the terminals of logistics companies should be gradually replaced by electric vehicles (EVs). Expansion planning of the power system in the terminal is needed to meet the increased EV charging need. Different expansion solutions with variable technologies
BackgroundThe literature on the relationship between anxiety and suicidal behaviors is limited and findings are mixed. This study sought to determine whether physicians noted anxiety symptoms and suicidality in their patients in the weeks and months before suicide.MethodsData were derived from a nationwide medical record review of confirmed suicides in Sweden in 2015. Individuals with at least one
