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Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Mer än 7000 kvinnor insjuknar varje år i bröstcancer, och cirka 1500 dör i sjukdomen. Incidensen av bröstcancer har stigit kontinuerligt sedan 1970-talet, och man uppskattar att en av tio kvinnor i Sverige kommer att utveckla bröstcancer någon gång under sin livstid. Den relativa överlevnaden i sjukdomeCancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to

Populärvetenskaplig sammanfattning: Klimatväxlingarna under sista istiden har alltid varit en debattfråga. Denna istids kallaste period inträffade för cirka 20.000 år sedan och benämns "istidsmaximum". Då var havsytan hundratjugo meter lägre än idag och det mesta vattnet var bundet i inlandsisarna. Klimatväxlingar försöker dagens kvartärgeologer att fastställa med en så bra tidsutlösningHigh-resolution analyses of sediments from two sites in Blekinge, south-eastern Sweden (the former Lake Togölen and Lake Bredsjön), were evaluated in order to establish the pollenstratigraphical position of the second and final drainage of the Baltic Ice Lake in relation to the Younger Dryas-Preboreal pollen zone transition. Remanent magnetisation and magnetic susceptibility were used to correlate

Purpose: To compare the performance of targeted temperature management (TTM) at 33 °C using intravascular (IC) vs. surface-cooling (SFC) devices after out-of-hospital cardiac arrest (OHCA). Methods: A post hoc analysis including OHCA patients randomized to hypothermia in the TTM2-trial (NCT02908308) comparing hypothermia with normothermia. The main outcome was cooling performance, defined as the p

A magnetic compass sense has been demonstrated in all major classes of vertebrates, as well as in many invertebrates. In mammals, controlled laboratory studies of mice have provided evidence for a robust magnetic compass that is comparable to, or exceeds, the performance of that in other animals. Nevertheless, the vast majority of laboratory studies of spatial behavior and cognition in murine rode

The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are comatose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying cardiac rhythm. These guidelines replace the recommendations on temperature management after cardiac arrest included in the 2021 post-resuscitation care guidelines co-issued b

The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are comatose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying cardiac rhythm. These guidelines replace the recommendations on temperature management after cardiac arrest included in the 2021 post-resuscitation care guidelines co-issued b

This thesis investigates the financial viability of green hydrogen production for mobility applications across four European countries: Germany, Norway, Denmark and Spain. Given the rising importance of hydrogen in hard-to-electrify sectors such as (heavy-duty) transport, the study focuses on understanding how system design and local energy conditions influence the Levelised Cost of Hydrogen (LCOH

Background: Magnetic resonance imaging (MRI) is recommended by guidelines to evaluate the severity of brain ischemia after cardiac arrest for functional outcome prediction. However, standardized assessment criteria are lacking. We have developed a semi-quantitative Cardiac Arrest Brain Ischemia (CABI) score to assess the extension of brain ischemia on MRI. Objectives: To evaluate the prognostic pe

Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien

Axonal injuries commonly contribute to poor functional outcomes following traumatic brain injury (TBI). To assess cerebral blood flow (CBF) and energy metabolic disturbances in a TBI model of widespread axonal injury, we exposed 105 adult mice to the central (midline) fluid percussion injury (cFPI) diffuse TBI model, or sham injury, and used 9.4 T magnetic resonance (MR) arterial spin labeling (AS

Background: Out of hospital cardiac arrest (OHCA) is a significant public health problem associated with high mortality and high healthcare costs. The Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) randomised clinical trial showed that targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months compared to normocapnia after OHCA. We aimed to est

Introduction: Cranioplasty, a surgical procedure to restore skull integrity and aesthetic contour following decompressive craniectomy, poses challenges in material selection and timing, driven by the lack of guidelines and ongoing regulatory changes. Research question: This study aimed to provide an overview of current cranioplasty practices in Europe, explicitly addressing a potential shift towar

Denna avhandling breddar rådande förståelser av stipendier och deras systematiska användning inom internationell högre utbildning genom att introducera en ny uppsättning teoretiska verktyg för att undersöka sådana satsningar. Med fokus på organisationer i Mexiko och Indonesien samt de studenter de sponsrade till svenska masterprogram mellan 2013 och 2020, utforskar studien värderingsprocesser, samThis thesis broadens prevailing understandings of scholarships and their systematic use in international higher education, introducing a novel set of theoretical tools for examining such endeavors. Focusing on organizations in Mexico and Indonesia and the students they sponsored in Swedish master’s degree programs between 2013-20, the study explores valuation processes, coordination puzzles and et

Objects created by 3D printers are increasingly used in various medical applications. Today, affordable 3D printers, using Fused Deposition Modeling are widely available. In this project, a commercially available 3D printer was used to replicate a conventional radiographic contrast detail phantom. Printing materials were selected by comparing their x-ray attenuation properties. Two replicas were p

The luminosity monitor LUCID (LUminosity Cherenkov Integrating Detector) employed in the ATLAS experiment at the LHC had to be upgraded for the second run of LHC (Run 2) that started in spring 2015. The increased energy of the proton beams and the higher luminosity implied that the Photomultipliers of the original LUCID detector had to be replaced for Run 2 to cope with the more demanding conditio

We have developed a method for simultaneous tomosynthesis and mechanical imaging, called DBTMI. Mechanical imaging measures the stress distribution over the compressed breast surface. Malignant tissue is usually stiffer than benign, which results in higher stress on the compressed breast and enables to distinguish malignant from benign findings. By combining tomosynthesis and mechanical imaging, w

Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Scree

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mitochondrial proteome in human isogenic induced pluripotent stem cell-derived neurons with and withou