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This master thesis project applies a mixed methods approach to fulfill the purpose of exploring how and in what ways digitalization transforms different retail categories. A theoretical framework is formulated using existing theories and research, from which four key variables are identified: distribution, interaction, competition and product offering. These variables, combined with an overarching

Synaptic degeneration and accumulation of the neurotoxic amyloid β-peptide (Aβ) in the brain are hallmarks of Alzheimer disease. Aβ is produced by sequential cleavage of its precursor protein, APP, by the β-secretase BACE1 and γ-secretase. However, Aβ generation is precluded if APP is cleaved by the α-secretase ADAM10 instead of BACE1. We have previously shown that Aβ can be produced locally at th

Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer sus

To confirm findings from a previous pilot study in a larger normal cohort and to study first trimester maternal serum levels of cell-free fetal hemoglobin (HbF) and the heme-scavenger α1-microglobulin (A1M) in patients who subsequently developed preeclampsia (PE), furthermore to evaluate these proteins as predictive biochemical markers of PE.

Once the Cultural Studies made its presence felt, the concept of culture was broadened so as to include the so-called “pop-culture”. It was very profitable to humanize culture and make it available to all, not only to elites. Extremes are discouraging. A middle ground should be established between the ups and downs. Culture should be democratic, which doesn’t mean it has to be confused with civili

The human nasopharynx is the main reservoir for Streptococcus pneumoniae (the pneumococcus) and the source for both horizontal spread and transition to infection. Some clinical evidence indicates that nasopharyngeal carriage is harder to eradicate with antibiotics than is pneumococcal invasive disease, which may suggest that colonizing pneumococci exist in biofilm communities that are more resista

This report presents an integrated simulation-based approach to study the on-site production of concrete frameworks by considering the multiple effects of weather on work task productivity and concrete curing process. The suggested approach enable to systematically study how different weather conditions and the use of climate-improved concrete in combination with different methods to shield concre

Purpose: The thesis aims to address the different roles incumbent firms can take in the emerging plant-based ecosystem and to contribute with new understandings related to these ecosystems. Theoretical framework: The theoretical foundation for the thesis is rooted in theories on systems thinking, ecosystems and with a discussion around the roles that are inherent in ecosystems. This is accompanie

Microbial hydrogen (H 2) cycling underpins the diversity and functionality of diverse anoxic ecosystems. Among the three evolutionarily distinct hydrogenase superfamilies responsible, [FeFe] hydrogenases were thought to be restricted to bacteria and eukaryotes. Here, we show that anaerobic archaea encode diverse, active, and ancient lineages of [FeFe] hydrogenases through combining analysis of ex

The notion of a language norm is far from clear. Lacking a conclusive explication, one may wonder what language studies are actually studying. Is it the experience of speakers? Is it their brains? Is it their behavior? Is it the product of expert intuitions? Even within linguistics the views seem scattered on this point, and no consensus has been reached on what the object of study in linguistics