Filetype
The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina
The Cherenkov Telescope Array (CTA) is the future observatory for ground-based imaging atmospheric Cherenkov telescopes. Each telescope will provide a snapshot of gamma-ray induced particle showers by capturing the induced Cherenkov emission at ground level. The simulation of such events provides camera images that can be used as training data for convolutional neural networks (CNNs) to differenti
Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho
This study investigates the neural encoding of speech features in hearing aid users using electroencephalography (EEG) during a simulated cocktail party scenario. The objective was to investigate neural tracking of various acoustic and linguistic features and how hearing aid noise reduction influenced this tracking. The features analyzed included the acoustic envelope, phonetic features, word onse
Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN
Motivation Efforts to address health disparities are often limited by the lack of robust computational tools for inferring genetic ancestry by calculating an individual's genetic similarity to continental groups. We have already shown that a preferred alternative to self-described race is using ancestry-informative markers (AIMs) that can be classified into ancestral components and used to estimat
Purpose: Developmental language disorder (DLD) has known consequences on academic performance, and adaptations to teaching methods and material are often required to counteract negative outcomes. This study used first-hand reports from students with DLD and their caregivers to explore how individual and school-related factors influence academic achievement and provision of educational support. Met
Soma design is intimately entangled with the politics, not only of design itself, but of bodies. We combine perspectives from soma design, political theory, and Sara Ahmed’s work The Cultural Politics of Emotions, to develop five political provocations that reflect on the politics of soma design and the possibilities and frictions therein. Inspired by soma design’s roots in somaesthetic philosophy
The Polarization and Impedance Controlled Car (PICC) presents an innovative approach for demonstrating and teaching key principles of electromagnetic field theory, specifically polarization and impedance. Designed as an interactive learning tool, the PICC utilizes a radio-controlled car, NanoVNA, Raspberry Pi, and handheld antennas to visualize real-time effects of polarization and impedance. The
In Latin-America -as in most parts of the world- indigenous peoples are ‘the poorest of the poor, and the most excluded of the excluded’. Poverty goes hand in hand with their situation of vulnerability, exclusion and disempowerment. How can this situation be changed? How to find adequate frameworks able to facilitate the overturn of their structural disenfranchisement? Departing from the jurisprud
Two-dimensional (2D) culturing of cancer cells has been indispensable for the development of anti-cancer drugs. Drug development, however, is lengthy and costly with a high attrition rate, calling to mind that 2D culturing does not mimic the three-dimensional (3D) tumour microenvironment in vivo. Thus, began the development of 3D culture models for cancer research. We have constructed a 3D 96-well
We analyze the problem of allocating indivisible objects and monetary compensations to a set of agents. In particular, we consider envy-free and budget-balanced rules that are least manipulable with respect to agents counting or with respect to utility gains. A key observation is that, for any profile of quasi-linear preferences, the outcome of any such least manipulable envy-free rule can be obta
Ghost quantitative trait loci (QTL) are the false discoveries in QTL mapping, that arise due to the "accumulation" of the polygenic effects, uniformly distributed over the genome. The locations on the chromosome that are strongly correlated with the total of the polygenic effects depend on a specific sample correlation structure determined by the genotypes at all loci. The problem is particularly
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a need for diagnostic tests has surfaced. Point-of-care (POC) antibody tests can detect immunoglobulin (Ig) G and M against SARS-CoV-2 in serum, plasma, or whole blood and give results within 15 min. Validation of the performance of such tests is needed if they are to be used in clinical practice. In this study, we
While ecosystem service (ES) assessments become a more and more important source of knowledge, there is a need for synthesis approaches that make the results usable to support decisions. Effective synthesis approaches can reduce the information burden produced by multiple ES assessments and help decision-makers to compare alternative options and to assess their impacts. In this review, we focus on
(KxNa1-x)NbO3 (KNN) and its solid solutions are considered as potential alternatives to traditional Pb-based piezoelectric materials. Recent investigations indicated that the local structure in KNN is much more complex than its long-range average structure. Here, we have undertaken a systematic investigation of the temperature-dependent evolution of local and average structures of KNN5 [(KxNa1-x)N
Over the past couple of decades, increased interdependencies between and institutional defragmentation of, our Critical Infrastructures (CIs) have created a setting were traditional risk management might no longer suffice. In particular, analysis and management of risks have evolved from being a predominantly intra-organisational task towards a process that also requires inter-organisational coord
Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350
