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Fever therapy in febrile adults : systematic review with meta-analyses and trial sequential analyses

Objective: To investigate the effects of fever therapy compared with no fever therapy in a wide population of febrile adults. Design: Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Data sources: CENTRAL, BIOSIS, CINAHL, MEDLINE, Embase, LILACS, Scopus, and Web of Science Core Collection, searched from their inception to 2 July 2021. Eligibility cr

Prognostic implications of structural heart disease and premature ventricular contractions in recovery of exercise

Premature ventricular contractions (PVCs) during recovery of exercise stress testing are associated with increased cardiovascular mortality, but the cause remains unknown. We aimed to evaluate the association of PVCs during recovery with echocardiographic abnormalities, and their combined prognostic performance. Echocardiographic abnormalities [reduced left ventricular (LV) ejection fraction, valv

Outcomes and interventions in patients transported to hospital with ongoing CPR after out-of-hospital cardiac arrest - An observational study

INTRODUCTION: The main objective was to present characteristics and outcome of patients without sustained field return of spontaneous circulation (ROSC) transported to hospital with ongoing cardiopulmonary resuscitation (CPR). Our secondary objectives were to investigate hospital-based interventions and the performance of the universal Termination of Resuscitation-rule (uTOR).METHODS: In this retr

Searches for New Physics Using Innovative Data Acquisition, Analysis, and Compression Techniques

När forskare blickar ut i universum ser de överallt spåren av en stor mängd osynlig massa. Massan finns där men det går inte att se den. Ungefär 80% av all massa i universum beräknas bestå av denna "mörka materia". Det är som att mänskligheten står på stranden och blickar ut över havet utan att veta vad vatten är. I partikelfysik studeras universums minsta beståndsdelar, elementarpartiklarna, för The high event rate delivered by the Large Hadron Collider (LHC) provides experiments with opportunities for new discoveries as well as challenges related to the large amounts of data recorded. Overcoming this requires innovative techniques in the three topics of this thesis: Data acquisition, data analysis, and data compression.In the data taking period of 2015-2018, the ATLAS experiment received

Quality of life for patients with advanced gastrointestinal cancer randomised to early specialised home-based palliative care: the ALLAN trial

BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.MethodsWe randomly assigned ambulatory patients w

A short delay from out of hospital cardiac arrest to call for ambulance increases survival

Aim To describe the relative impact on survival of the delay from estimated time of collapse to call for an ambulance among patients who suffer from a bystander witnessed out of hospital cardiac arrest of a cardiac aetiology. Methods A majority of all ambulance organizations in Sweden (covering 85% of Sweden inhabitants) participate in a National survey of out of hospital cardiac arrest. Results I

Nature's choice of genes controlling chronic inflammation.

Inflammation is a physiological response that may go uncontrolled and thereby develop in a chronic way. This seems to happen in many common diseases of autoimmune, degenerative, or allergic character. Rheumatoid arthritis (RA) is by definition a chronic disease with an autoimmune inflammatory attack on diarthrodial cartilaginous joints. The development of new treatment neutralizing cytokines invol

Swedish health care providers' experience and knowledge of female genital cutting.

We sought to evaluate the experiences and knowledge of health care providers in Sweden regarding female genital cutting (FGC) as a health issue. Questionnaires (n = 2,707) were sent to providers in four major cities in Sweden and evaluated by means of descriptive statistics. Twenty-eight percent (n = 769/2,707) responded, of whom 60% had seen such patients. Seven providers, including 2 pediatricia

Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.

The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, b

Vascular receptor changes in ischemic stroke

Popular Abstract in Swedish Stroke är en vanlig och mycket allvarlig form av hjärt-kärlsjukdom som uppkommer på grund av försämrat blodflöde i en del av hjärnan. Eftersom hjärnan är extremt beroende av kontinuerlig tillförsel av syre och näringsämnen leder tillståndet snabbt till hjärnskada. Det finns tre typer av stroke; hjärninfarkt, hjärnblödning och subaraknoidalblödning (blödning under en hjäThe present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor regulation. For functional studies

Predictors of falls in the elderly by location

Background and aims: In the elderly, balance and walking impairments are assumed to play an important role in causing falls. We have assessed prospectively the predictive ability of health, function and balance variables regarding falls and their location. Methods: Falls which occurred during one year in a random sample of 307 women aged 75 years and over (mean 80.8 years, response rate 74.5%) liv

Exposure assessment for the prevention of musculoskeletal disorders

Popular Abstract in Swedish Exponeringsskattning för att hindra uppkomst av belastningsskador Skador på muskler som uppkommer av olämpliga arbetsrörelser och arbetsställningar (belastningsskador) utgör ett stort problem i alla industrialiserade länder. Definitionen av vad som innefattas i begreppet arbetsskada varierar mellan olika länder, varför det är svårt att göra jämförelser. Kostnader för arWork-related musculoskeletal disorders of shoulder/neck are a major and increasing problem. Beside the pain, they involve high cost for the employer and society. The total expenditure for the musculoskeletal disorders of the neck and upper limb have been estimated to 0.5-2.0% of the Gross National Product (GNP) in the Nordic countries. Due to the lack of precise knowledge of exposure/response rela

The Role of Transesophageal Echocardiography in Clinical Decision-Making in Patients with Stroke or Atrial Fibrillation

Popular Abstract in Swedish Ekokardiografisk undersökning av hjärtat utvecklades i Lund i början av 1950 talet av kardiologen Inge Edler tillsammans med fysikern Helmuth Hertz och har under de första 30 åren huvudsakligen utförts via bröstkorgsväggen så kallat transthorakalt ultraljud. Under 1980 talet utvecklades tekniken och man fick instrument som via matstrupen kunde utföra en ekokardiografiskThe subject of this thesis is the clinical use of transesophageal echocardiography (TEE) in patients with stroke or atrial fibrillation. Subjects were examined with echocardiography and sonography of the carotid artery. A control group of randomly selected volunteers without cerebrovascular disease was compared to patients with ischemic stroke. Cardiac pathology was classified as minor potential e

Konfirmandernas bildningsresa : Ungdomars berättelser om sitt deltagande i konfirmandundervisning

Popular Abstract in Swedish Under de senaste åren har det svenska samhället förändrats när det gäller dess förhållande till religion och till Svenska kyrkan. Från att ha varit en statskyrka fram till år 2000 och därmed tidigare tillhört enhetskulturen och varit en majoritets kyrka, är Svenska kyrka idag en kyrka som är fri från staten och verkar i ett mångkulturellt samhälle där många olika kultur