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This study investigates the practical integration of Building Information Modelling (BIM) and Building Energy Modelling (BEM) for energy-efficient building design. This research explores the challenges and opportunities of openBIM-to-BEM workflows by drawing on a literature review and a real-world case study in Östergötland County, typical of the Million Programme, a large public housing initiativ
This work is devoted to the development and comprehensive validation of a new interatomic potential for bcc and hcp refractory alloys based on the Wsingle bondMosingle bondNbsingle bondTasingle bondZrsingle bondTi system. The presented model allows the simulation of various structural transformations, as well as the behavior of crystal defects in several of the phases observed in this system. The
This study examines farmers' willingness to sell straw for energy and material applications in Scania, Sweden. Using interviews and surveys, we tested three empirical consequences derived from the premise that missing data on farmers' willingness to sell straw for energy may misrepresent the biomass supply in potential assessments. Findings reveal willingness to sell straw depends on end use, with
Parkinson's disease (PD) is characterized by a set of motor symptoms that depend on nigrostriatal dopaminergic degeneration and respond well to pharmacological dopamine replacement using L-DOPA. However, replacing dopamine with either L-DOPA or dopamine receptor agonists leads to the appearance of motor and nonmotor complications within a few years. Strong emphasis is currently placed on developin
BackgroundSome patients scheduled for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) only undergo explorative laparotomy (open/close procedure) due to extensive tumor spread or challenges in achieving complete cytoreduction (CC0). This study aimed to evaluate the surgical outcomes and overall survival in patients with peritoneal surface malignancy (PSM) who only
Mechanisms of the aerosol indirect effects (AIEs) from ice nucleating particles (INPs) are investigated with the cloud-resolving “aerosol–cloud” (AC) model with a hybrid bin–bulk microphysics scheme coupled with a radiation scheme in 1) continental deep convection observed during the Midlatitude Continental Convective Clouds Experiment (MC3E) over Oklahoma and 2) supercooled stratiform clouds obse
Thermal runaway in lithium-ion battery cells poses significant safety risks due to rapid heat generation and potential thermal propagation within a battery system. This study investigates the total heat released and the fraction of energy contained in gas and particles ejected during thermal runaway using a purpose-built calorimeter setup. The results show that the fraction of ejected heat is sign
Anatase TiO2 is recognized as a promising negative electrode material when employing “water-in-salt” electrolytes in high voltage aqueous lithium-ion batteries. However, the catalytic property of water splitting aggravates the hydrogen evolution reaction, which hinders the formation of a stable solid electrolyte interphase (SEI) on the electrode surface and therefore results in poor cycling perfor
Introduction Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often termed treatment-resistant depression (TRD) and is seen in over one-Third of people with MDD. Reasons for treatment resistance are not well established, nor is the definition of TRD. Duration and se
Biobased polyesters are emerging as sustainable alternatives for hot-melt adhesives (HMAs) owing to their tunable adhesion properties, facile processing, and versatile end-of-life options. Here, we report on the design of low-temperature (100 °C) HMAs, derived from oxygen-rich lignin-based copolyesters synthesized via copolymerization of a syringic acid-derived aromatic monomer with biobased aliph
Background: Joint pain and chronic back pain are highly prevalent in the aging population and have a large impact on life quality. As the underlying mechanisms are not fully understood, this exploratory cross-sectional study aimed to discover proteins and pathways associated with these two pain conditions in Swedish 70-year-old men. Methods: Plasma proteins (n = 720) were measured in participants
This paper explores an initiative by a local government in Rättvik, Sweden, to increase the consumption of local food in the municipal kitchens. It explores public procurement of local food as a way for local governments to address sustainability and climate goals while meeting residents’ demand for ‘good’ local food. Through a qualitative case study reviewing food and procurement policies across
Introduction.Kraft black liquor is a side-stream produced during the kraft pulping process containing lignin, hemicelluloses and cooking chemicals. The stream is usually evaporated and burned in the recovery boiler to recover the cooking chemicals and generate energy. The mill is, however, often/sometimes limited by recovery boiler capacity, and removing some of the lignin from kraft black liquor
Researchers have widely applied discharge simulation using artificial neural networks (ANNs) and have gained prominence in water resources. Morphological features, watershed urbanization, and climate change influence hydrological variables. Thus, data-driven models need to be able to identify the hydrological relationships without explicitly stating the physical processes. The main objectives of t
Creating software tools that address the needs of a wide range of decision-makers requires the inclusion of differing perspectives throughout the development process. Software tools for biodiversity conservation often fall short in this regard, partly because broad decision-maker needs may exceed the toolkits of single research groups or even institutions. We show that participatory, collaborative
The use of CRISPR-Cas bacterial adaptive immunity system components for targeted DNA changes has opened broad prospects for programmable genome editing of higher organisms. The most widely used gene editors are based on the Cas9 effectors of the type II CRISPR-Cas systems. In complex with guide RNAs, Cas9 proteins are able to directionally introduce double-stranded breaks into DNA regions that are
Starting with the lead compound roquinimex, a selection of 3-quinolinecarboxamide derivatives were synthesized and evaluated for the treatment of the autoimmune disease multiple sclerosis. Structure-activity relationships were established in animal studies and from these, laquinimod was chosen as the drug candidate due to its superior potency and toxicological profile as compared to roquinimex. Ho
Additive manufacturing (AM) is revolutionizing industrial production by enabling the fabrication of complex, customized components with reduced material waste. However, the scheduling of AM machines presents significant challenges in terms of optimizing both time-related performance and energy consumption. This paper introduces a novel multi-objective mixed-integer linear programming (MILP) model
