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This paper describes a heterogeneous competitive flow immunoassay with a high sample throughput which can be used for the screening of smaller analytes in various samples. The method is based on off-line incubation of the analyte (Ag), a fluorescent labelled tracer (Ag*) and the corresponding antibody (Ab). The separation of bound (Ab-Ag*) and free tracer (Ag*) is based on a size exclusion and rev
This paper proposes an IV-based panel unit root test that is general enough to accommodate general error serial and cross-section dependence, and a potentially nonlinear deterministic trend function. These allowances make the new test one of the most general around. It is also very simple to implement. Indeed, the IV statistic is asymptotically invariant to not only to all nuisance parameters char
This paper describes an American Monte Carlo approach for obtaining fast and accurate exercise policies for pricing of callable LIBOR Exotics (e.g., Bermudan swaptions) in the LIBOR market model using the Stochastic Grid Bundling Method (SGBM). SGBM is a bundling and regression based Monte Carlo method where the continuation value is projected onto a space where the distribution is known. We also
This paper presents a computationally efficient technique for the computation of exposure distributions at any future time under the risk-neutral and some observed real-world probability measures; these are needed for the computation of credit valuation adjustment (CVA) and potential future exposure (PFE). In particular,we present a valuation framework for Bermudan swaptions. The essential idea is
Objective: To investigate the influence of cardiovascular risk factors, including fasting plasma glucose (FPG), on the association between electrocardiographic (ECG) and echocardiographic left ventricular hypertrophy (LVH) in an elderly population. Methods: We tested cross-sectional associations between electrocardiographic and echocardiographic LVH, defining LVH according to the Sokolow-Lyon volt
In this study steady-state natural convection for Al2O3 and CuO nanofluids inside different enclosures are numerically investigated. Natural convection is concerned due to a temperature difference between hot and cold surfaces. Rectangular and curved enclosures are investigated. The Boussinesq approximation is used to form the governing equations and the commercial software package ANSYS Fluent ve
Background: High amounts of alkali in the fuel, such as potassium and sodium in combination with high amounts of chlorine increase the chances of high-temperature corrosion, deposit growth and slagging and fouling. These risks need to be reduced to avoid losses in revenue due to unplanned stops and costs related to increased maintenance. Aims:This research targets the development of a new cell to
Ultrafast electronic and structural dynamics of matter govern rate and selectivity of chemical reactions, as well as phase transitions and efficient switching in functional materials. Since x-rays determine electronic and structural properties with elemental, chemical, orbital and magnetic selectivity, short pulse x-ray sources have become central enablers of ultrafast science. Despite of these st
A windowless silicon (Si) diode (4 mm2) was evaluated as alpha particle detector and spectrometer for field measurements. It was irradiated with alpha particles from a 241Am (2.3 kBq) and a 210Po (9 kBq) source at source-detector distances (SDD) of 0.5, 1.0 and 1.8 cm. The energy resolution in terms of full width at half maximum was 281, 148 and 113 keV for SDD of 0.5, 1.0 and 1.8 cm, respectively
Multidimensional LC-MS based shotgun proteomics experiments at the peptide level have traditionally been carried out by ion exchange in the first dimension and reversed-phase liquid chromatography in the second. Recently, it has been shown that isoelectric focusing (IEF) is an interesting alternative approach to ion exchange separation of peptides in the first dimension. Here we present an improve
Parabolic sub-sample interpolation for 2D block-matching motion estimation is computationally efficient. However, it is well known that the parabolic interpolation gives a biased motion estimate for displacements greater than |y.2| samples (y = 0, 1, …). Grid slope sub-sample interpolation is less biased, but it shows large variability for displacements close to y.0. We therefore propose to combin
This chapter explores how universities in Sweden have approached the challenges of inclusive development and social innovation. Whereas the higher education system has been quite successful in providing access to previously excluded groups, the concept of social innovation applied to solving social problems has not yet been integrated into the policies and practices of the university innovation sy
Technetium is a synthetic element with no stable isotopes, produced as waste in nuclear power plants and in cyclotrons used for nuclear medicine. The element has high mobility, in the form of TcO4 −; its determination is therefore important for environmental protection. Technetium is found in low concentrations and therefore common methods for its analysis include long treatments in several steps
This study aims to assess the potential of trees for integration in urban development by evaluating the damage caused by trees in relation to various tree characteristics. Tree damage to permeable pavement systems and other urban structures such as impermeable pavements, kerbs, roads, retaining walls, footpaths, walls and buildings were assessed to identify the most suitable trees for the urban en
This article explores push-pull dynamics in television drama production and reception. Push-pull dynamics are understood as complicated power relations in the transactions between television industries and audiences. The research is underpinned by qualitative data, drawing on more than 170 participants in interviews, focus groups, and participant observations, with producers and audiences from Nor
In a recent issue of Nature, Falkner et al. (2016) use chronic two-photon imaging, virus-based transsynaptic tracing, and dynamic calcium indicators to elegantly demonstrate extensive in vivo functional maturation and target-specific functional integration of transplanted embryonic mouse cortical progenitors into adult lesioned visual cortical circuits.
Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazole)] (1), trans-[PtCl4(cha)(NH3)] (2), cis-[PtCl4(cha)(NH3)] (3) (cha=cyclohexylamine), and cis-[PtCl4(NH3)2] (4) has been investigated at 25 °C in a 1.0 M aqueous medium at pH 2.0–5.0 (1) and 4.5–6.8 (2–4) using stopped-flow spectrophotometry. The redox reactions follow the second-order rate law d[
