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Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is imperfect for predicting outcome, which results in overtreatment for many patients, and for others, leads to death from recurrent disease. Therefore, additional criteria are needed to better personalize care and maximize treatment effectiveness and survival.

Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc

Theoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the concepts of stolen knowledge (Brown & Duguid, 1996) and landscape of learning (Bjerstedt, 2014). Based on an extensive interview study with SwedishTheoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the concepts of stolen knowledge (Brown & Duguid, 1996) and landscape of learning (Bjerstedt, 2014). Based on an extensive interview study with Swedish

Hypoxia and acidosis are inherent stress factors of the tumor microenvironment and have been linked to increased tumor aggressiveness and treatment resistance. Molecules involved in the adaptive mechanisms that drive stress-induced disease progression constitute interesting candidates of therapeutic intervention. Here, we provide evidence of a novel role of heparan sulfate proteoglycans (HSPG) in

BACKGROUND: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.METHODS: Flow cytomet

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of over

Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spectrometry-based proteomic data was obtained from five independent cohorts, including 489 tissue samples from 394 patients with accompanying clinical metadata. We

Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a

Background: Induced hypothermia after cardiac arrest is neuroprotective in several animal models of cardiac arrest, but few high-quality studies have been conducted in larger animals. Recent clinical trials have questioned the beneficial effects of post-ischemic hypothermia. This study investigated whether immediate cooling or a 2-h delay in cooling to 33 °C after cardiac arrest was neuroprotectiv

The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met

Microsoft Word - halvtid, blankett.doc Certificate, Halfway review for PhD-education Name of doctoral student: Personal identity number: Department: Email address: THE DOCTORAL STUDENT'S PERFORMANCE AT THE SEMINAR Component Comments and recommendation Written summary of the thesis project. Oral presentation. Discussion/handling of questions. ACTIVITY, PROGRESS AND QUALITY OF RESEARCH WORK Componen

https://www.intramed.lu.se/en/sites/intramed.lu.se.en/files/2024-11/Certificate%20half%20way%20review%20241126.pdf - 2026-06-04

SMMV35 Retail and Place Development Lund University Faculty of Social Sciences SMMV35, Retail and Place Development, 15 credits Retail och platsutveckling, 15 högskolepoäng Second Cycle / Avancerad nivå Details of approval The syllabus was approved by the board of the Department of Service Management and Service Studies on 2020-02-26 and was last revised on 2023-02-14 by the board of the Departmen

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2023-02/Kp_SMMV35_eng_HT23_230214.pdf - 2026-06-04

Microsoft Word - Handbook for new Geology students 2016 Study guide Geology Lund University Sölvegatan 12 Lund Sweden Welcome to Lund University and the Department of Geology (Geologiska institutionen) We hope that you will like it here and enjoy your studies. This handbook provides information about the department, the structure of programmes and courses, as well as student organisations and othe

https://www.geology.lu.se/sites/geology.lu.se/files/handbook_for_new_geology_students_2016-08-15.pdf - 2026-06-04

Konstnärliga fakulteten i Malmö Dnr: U 2015/183 Allmän studieplan för utbildning på forskarnivå i Film och media ledande till konstnärlig doktorsexamen 1. Identifikation Utbildningens namn och inriktning: Utbildning på forskarnivå i film och media Kod: KOFIME00 Omfattning i högskolepoäng: 240 Nivå: Forskarnivå Examensbenämning: Konstnärlig doktorsexamen i film och media Engelsk examensbenämning: D

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/allman_studieplan_film_och_media_150603.pdf - 2026-06-04

The future of the European Common Agricultural Policy in the next Multiannual Financial Framework Lärosäten Syd – Universities in South Sweden | Website larosatensyd.se/en Date: 2025-10-08 Author: Martin Jönsson, Trainee, Universities in South Sweden Brussels Representation, autumn semester 2025 The future of the European Common Agricultural Policy in the next Multiannual Financial Framework An an

https://www.mgeo.lu.se/en/sites/mgeo.lu.se.en/files/2026-01/CAP_PolicyBriefing_2025.pdf - 2026-06-04

Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor Development. 2015 Sep 15; 142(18): 3166–3177. doi: 10.1242/dev.122747: 10.1242/dev.122747 PMCID: PMC4582174 PMID: 26395143 Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor Marie

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/comprehensive_analysis_.pdf - 2026-06-04

Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping

Single-cell RNAseq is a routinely used method to explore heterogeneity within cell populations. Data from these experiments are often visualized using dimension reduction methods such as UMAP and tSNE, where each cell is projected in two or three dimensional space. Three-dimensional projections can be more informative for larger and complex datasets because they are less prone to merging and flatt

Production of red blood cells relies on proper mitochondrial function, both for their increased energy demands during differentiation and for proper heme and iron homeostasis. Mutations in genes regulating mitochondrial function have been reported in patients with anemia, yet their pathophysiological role often remains unclear. PGC1β is a critical coactivator of mitochondrial biogenesis, with incr