Search results

Inferring the cell-type composition of bulk samples can provide biological insight. While bulk transcriptomics data has been extensively used for this purpose, the use of proteomics data has remained unexplored until recently. This study evaluates computational approaches for estimating immune cell composition using bulk sample proteomics data. Leveraging defined immune cell populations and simula

A radiation detection system combining a single-sided silicon strip detector (SSSD) and a high-purity germanium (HPGe) COMPEX detector module together with its anti-Compton shield (ACS) was set up at Lund University for environmental sample measurements. This system enables high sensitivity ––-coincidence analysis, enhancing the identification level of radionuclides in environmental samples. A com

This ESMO CPG provides key recommendations and algorithms for managing DLBCL, FL, HL, MCL, MZL, PCNSL and PTCL. •It covers epidemiology, diagnosis, staging, risk assessment, treatment of primary and refractory disease and follow-up. •Treatment algorithms for each lymphoma type are provided. •The author group encompasses a multidisciplinary group of experts from different institutions and countries

Surface tension is crucial for nanowire vapor liquid solid (VLS) growth models and simulations of growth under external stimuli. A promising method involving imaging droplet deformation under an external electric field has previously been used to report the surface tension of the AuSi eutectic catalyst on Si-nanowires. However, simplified assumptions in this approach led to a significantly lower v

Context: AI technologies are increasingly embedded in products and software engineering processes of industrial IoT, autonomous systems, and cyber-physical systems. It is therefore essential to ensure alignment with safety, reliability, and ethical standards. However, practical software engineering methods for managing misalignment risks remain underdeveloped. Objective: This study aims to explore

Ensuring functional safety is crucial for the deployment of autonomous systems in real-life dynamic environments, as they must operate reliably and safely among humans. However, existing safety systems are designed with a closed-world assumption and can over-constrain the system by shutting down the robot at every safety violation, limiting the robot’s ability to complete its tasks. To address thi

Objective: The aim of this study was to explore experiences and challenges in handling feedback and criticism among early career surgeons. Design: This study is part of a prospective, exploratory, longitudinal study evaluating surgical residents throughout residency. Semi-structured interviews were conducted with medical doctors applying to a locum or residency position in a surgical specialty. An

The rapid growth of smart logistics, driven by IoT devices and data-intensive applications, necessitates secure, scalable, and efficient computing frameworks. As the edge-fog-cloud (EFC) paradigm supports real-time data processing, it faces significant security threats and attacks, including privacy risks, data breaches, and unauthorized access. To address these security threats and attacks, block

Improving lignocellulosic biorefineries is a crucial step in transitioning from a fossil-based economy to a bio-based one. These biorefineries convert lignocellulosic biomass feedstocks into value-added products such as biofuels, biopower, biochemicals, and biomaterials, while also recovering valuable components from underutilized process streams. Pulp and paper mills are lignocellulosic biorefine

Background: Laparoscopic liver resection (LLR) appears to be safe and effective as open liver resection (OLR) for hepatocellular carcinoma (HCC). However, studies comparing LLR with ORL in elderly patients are limited. The purpose of this study is to compare the clinical outcomes of LLR versus OLR for HCC in elderly patients. Methods: A retrospective analysis was made comparing laparoscopic (n = 1

Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the mu

This paper compares conditions and costs for RES-E grid connection in selected European countries. These are Germany, the Netherlands, the United Kingdom, Sweden, Austria, Lithuania and Slovenia. Country specific case studies are presented for wind onshore and offshore, biomass and photovoltaic power systems, as based on literature reviews and stakeholder interviews. It is shown that, especially f

This paper presents a model for reversed-phase purification of insulin from desamido insulin. The system is described by a reaction dispersive model with a competitive Langmuir isotherm. A model building and calibration method is presented and the model's region of validity is defined. The model is calibrated using only two-component experiments on the raw mixture by the inverse method and then ex