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Motivation: CoGenT++ is a data environment for computational research in comparative and functional genomics, designed to address issues of consistency, reproducibility, scalability and accessibility. Description: CoGenT++ facilitates the re-distribution of all fully sequenced and published genomes, storing information about species, gene names and protein sequences. We describe our scalable imp
The internal carotid artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats has a thicker media than that of normotensive Wistar Kyoto rats as early as 15 days of age; furthermore, the media-to-lumen ratio is increased in the larger pial arteries. Since several studies have indicated that the mean arterial pressure is slightly elevated in spontaneously hypertens
IEEE802.11 WLANs show increasing growth in popularity. Since these networks operate in the unlicensed ISM bands where the number of non-overlapping channels is limited, the growing number of wireless nodes leads to interference. It is well known that the interference leads to degraded performance of WLANs, especially in densely populated areas where the number of overlapping nodes is very large. C
Peptide binding to HLA molecules is a critical step in induction and regulation of T-cell mediated immune responses. Because of combinatorial complexity of immune responses, systematic studies require combination of computational methods and experimentation. Most of available computational predictions are based on discriminating binders from non-binders based on use of suitable prediction threshol
A regulation on nutrition and health claims made on foods was introduced in the European Union in 2007. This Regulation provides opportunities for the use of health claims on foods in Europe, including reduction of disease risk claims. The Regulation will be fully implemented by January 2010. A community list of permitted and rejected claims will be established and made available to the public. So
We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle similar to the albumin binding domain of protein PAB from Peptostreptococcus magnus. The two domains share 59% sequence identity, are thermally very stable, and bind to the same site on human serum albumin.
Event-related potentials (ERPs) and behavioral measures were used to investigate recognition memory and source-monitoring judgements about previously perceived and imagined pictures. At study, word labels of common objects were presented. Half of these were followed by a corresponding picture and the other half by an empty frame, signalling to the Ss (aged 20-35 yrs) to mentally visualize an image
The paper considers a problem of routing, protection and load balancing in the IP/MPLS network. A network design problem combining all these aspects is presented. Proportionally fair distribution of residual bandwidths on links is used for load balancing, and protection is achieved with failure-dependent backup paths. The efficiency of the proposed approach is tested by combining optimization and
We review and analyze the possible advantages and disadvantages of plant-stress-related metabolic and structural changes on applications in the fruit and vegetable processing industry. Knowledge of the cellular and tissue transformations that result from environmental conditions or industrial manipulation is a powerful means for food engineers to gain a better understanding of biological systems i
Background: The usual onset of Crohn's disease (CD) is between 15 and 30 years of age, thus affecting people during their most economically productive period in life. Methods: This study intended to estimate societal costs and health-related quality of life (HRQoL) in Swedish patients in different stages of CD. Cross-sectional data on disease activity (measured with the Harvey-Bradshaw Index [HBI]
All physical, chemical and biological processes produce heat and isothermal calorimetry is a general measurement technique to study all kinds of processes by the heat they produce. This paper gives several examples of studies of biological processes in the food area using isothermal calorimetry. It is for example shown how different unit operations influence respiration of vegetable tissue, how th
A rapid protocol was developed for constructing plasmid libraries from small quantities of genomic/metagenomic DNA. The technique utilizes linker amplification with topoisomerase cloning and allows for inducible transcription in Escherichia coli. As proof of principle, several anti-Bacillus lysins were cloned from bacteriophage genomes and an aerolysin was cloned from a metagenomic sample.
Instability of the pre-ocular tear film causes symptoms of dry eyes. Tear film instability may be caused by exposure to air pollutants, but identification of causative agents is often difficult. We describe an in vitro technique for assessment of putative agents on the surface activity of Meibomian lipids. The lipids were obtained from bovine eyelids and dissolved in chloroform. Surface activity o
We study the role of strong particle/particle interactions and stochastic fluctuations emanating from the micro-/sub-grid scale, in the context of a simple prototype hybrid system con- sisting of a scalar linear ordinary differential equation (ODE), coupled to a microscopic spin flip Ising lattice system. Due to the presence of strong interactions in the lattice model, the mean-field approximation
Critical to the successful application of deep brain stimulation for the treatment Parkinson's disease is the proper selection of patients who will reliably benefit from this procedure and the successful evaluation of the responses obtained. This review will discuss the various factors influencing patient selection and summarize the recommended approach to patient assessment by using the Core Asse
Research on HIV vaccines, as well as studies on HIV pathogenesis in human and SIV in the macaque model, require the availability of simple and standardized assays for quantification of neutralizing antibodies to primary virus isolates. We have recently developed and standardized assays using human cell lines engineered to express CD4 and co-receptors for HIV and SIV entry. One cell line originated
The presence of ribonucleic acid hairpin structures is important for proper processing of the genetic information in living cells. Recent studies indicate that interactions between platinum based anticancer active metal complexes and hairpin motifs result in a change of their three-dimensional structure combined with a decrease of the melting temperature. We here report a study of the reaction bet
