Filetype
Aim: In this study, we aimed to investigate whether changes in cerebrovascular voltage-dependent calcium channels and non-selective cation channels contribute to the enhanced endothelin-1-mediated vasoconstriction in the delayed hypoperfusion phase after experimental transient forebrain ischaemia. Methods: Experimental forebrain ischaemia was induced in Wistar male rats by a two-vessel occlusion m
Context: CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in adipogenesis and hepatic glucose and lipid metabolism. Objective: To test the hypothesis that adipose tissue C/EBPalpha regulates genes in lipid and glucose metabolism and to test for association between a polymorphism in C/EBPalpha and metabolic parameters. Design and Methods: Adipose tissue C/EBPalph
Although smoking is associated with cardiovascular disease (CVD), many individuals remain healthy after many years of smoking. The population based cohort 'Men born in 1914' was used to investigate whether the occurrence of non-invasively detected atherosclerosis among smokers is associated with lung function [(i.e. height-adjusted forced expiratory volume during 1 s (FEV1.0) and vital capacity (V
Nature has been recognized as a rich source of potentially useful chemicals. Throughout the years, phytochemical studies have led to the discovery of an enormous number of natural products, their chemical diversity is unique and many of them possess various biological activities. As a contribution, this thesis presents the results obtained from the phytochemical study of four Bolivian plants. Sene
Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from
INTRODUCTION: Cartilage Oligomeric Matrix Protein (COMP) is an oncogenic protein that has been associated with a decrease in infiltrating T-cells in periampullary adenocarcinoma. This study aimed to investigate whether this is also the case for colorectal cancer (CRC) and to evaluate the relationship between COMP expression and clinopathological features.METHODS: Immunohistochemistry was used to d
The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-alanine.
Background and aims: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. Methods: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA).
The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined. We performed an investigation of the expression of MYC protein in a cohort of 251 MCL patients complemented by analyses of structural aberrations and mRNA, in a sub-cohort of patients. Fourteen percent
INTRODUCTION Families may benefit from increased focus on partner emotional wellbeing during pregnancy and the perinatal period. Our aim was to explore the risk for depression and anxiety during pregnancy and one year postpartum in relation to partners’ self-reported health, sense of coherence, social support, and lifestyle factors. METHODS This is a longitudinal cohort study using three questionn
In the seminal cases C-156/21 and C-157/21 (‘Budget Conditionality Cases’) the Court of Justice of the European Union demonstrated a shift in the perception of the operational functionality of foundational values of the EU, establishing that the rule of law is a founding value of the Union which represents a legal norm and imposes an obligation on the Member States to comply with its constituent e
This study examines the impact of the extensive climatic and environmental changes associated with the Early Holocene on the feeding ecology of aurochs, European bison, red deer, and Eurasian elk in southern Scandinavia from radiocarbon dates and analysis of stable carbon and nitrogen isotopes. Molecular sex information is utilised in the study of aurochs to understand the underlying reasons behin
Context. Globular clusters (GCs) carry information about the formation histories and gravitational fields of their host galaxies. It was found before that the radial profiles of the volume number density of GCs in GC systems (GCSs) follow broken power laws, while the breaks occur approximately at the a0 radii. These are the radii at which the gravitational fields of the galaxies equal the galactic
This study uses a specifically constructed sub-national dataset on Ebola Virus Disease (EVD) outbreak cases, deaths, and CFR in order to look at the question of how important various socio-economic factors were in determining the intensity and severity of the 2013-2016 EVD outbreak in Guinea, Liberia, and Sierra Leone. The results of the OLS model shows that the socio-economic conditions in differ
Title: Can new companies be in a position to save the world? A qualitative study in how small, newly started companies, with an expressed focus on sustainability, work operatively in their supply chain. Seminar date: 31st of May 2018 Course: FEKH99, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 University Credits Points (UPC) or ECTS Authors: Alexandra Karas
