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The high-Mr alkali-stable form of cathepsin B was purified from purulent human sputum. It was shown to solubilize proteoglycan monomer entrapped in polyacrylamide at a rate comparable with that of human lysosomal cathepsin B. Like the enzyme from lysosomes, sputum cathepsin B was bound by human alpha 2-macroglobulin, which inhibited its action on proteoglycan. Cystatin C in purulent sputum was sho

This research tries to understand how young career-oriented women perceive social norms about being a female in the business world and how women navigate through competing discourses. Examining the social identity theory that assists us to understand how perceptions of social identities and dominant discourses affect formation of identity. Furthermore, taking leverage from research regarding ident

INTRODUCTION: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior

BACKGROUND: Triglyceride-glucose (TyG) index is a useful low-cost marker of insulin resistance. We aimed to evaluate the association between TyG index and arterial stiffness, incidence of diabetes, adverse cardiovascular outcomes, and all-cause and cardiovascular mortality in two large prospective Swedish cohorts, the Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CV) and the Malmö Preven

Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the

Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedis

BACKGROUND: Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and safety of selepressin, a novel V1A-selective vasopressin analogue, was examined in a phase IIa trial in septic shock patients.METHODS: This was a randomized, double-blind, pla

This paper studies the nexus between income and wealth inequality, and the ecological footprint in the United States and France from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. We find some support for income inequality affecting the ecological footprint in the United States and that the relationship has changed over time. We find no such result

OBJECTIVE: Previous studies have shown that serum levels of testosterone correlate negatively with leptin and positively with insulin-like growth factor binding protein 1 (IGFBP-1). The present study examined whether these associations are linked.DESIGN AND PATIENTS: The association between serum levels of IGFBP-1, free testosterone and insulin on one hand and leptin on the other hand were investi

Proteins are dynamic entities that intermittently depart from their ground-state structures and undergo conformational transitions as a critical part of their functions. Central to understanding such transitions are the structural rearrangements along the connecting pathway, where the transition state plays a special role. Using NMR relaxation at variable temperature and pressure to measure aromat

Rural destinations like Kullahalvön are becoming more and more popular as tourists look for authentic local experiences. However, the synergy between stakeholder engagement and rural branding has not received much attention in studies. We explore the complexities of destination branding and stakeholder collaboration in Kullahalvön in this qualitative study. By means of a comprehensive document ana

Many locations in Indonesia such as small islands and remote villages on the main islands are not connected to the main electricity grid, and may never be as they are too remote for grid extensions to be economically justifiable. Therefore, many either do not have electricity or are dependent on expensive diesel transports to fuel their stand alone, diesel powered mini-grids. Using a hybrid renewa

INTRODUCTION: Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics and immune-suppressive pathways limiting T-cell mediated anti-tumor immunity.METHODS: In this observational study we analyzed by immunohistochemistry, gene express

The neutral protease cathepsin G belongs to a family of hematopoietic serine proteases stored in the azurophil granules of the neutrophil granulocyte. To investigate the function of asparagine-linked carbohydrates in neutrophil serine proteases, we constructed a mutant cDNA, coding for human cathepsin G deficient of a functional glycosylation site, for use in a transgenic cellular model. Wild type

https://www.ses.lu.se/sites/ses.lu.se/files/ll_edmc12_170831.pdf - 2026-07-13

Machine learning (ML) started as hype and an academic dream and throughout recent years has become reality for many organizations that are working towards becoming data-driven when making vital business decisions with the use of great amounts of data. Capitalizing on ML re-quires expertise which the job market is struggling to provide. This resulted in the intro-duction of the concept of automatin

Med bakgrund i FN generalförsamlings begäran om ett rådgivande yttrande från Internationella domstolen (ICJ) gällande staters ansvar i klimatfrågan, enligt resolution A/77/L.58, undersöker denna studie hur icke-statliga organisationer (NGO:er) framställer statligt ansvar för klimatrelaterade människorättskränkningar. Särskild vikt läggs vid rätten till liv samt rätten till ett rent, hälsosamt och