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Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the peroxide regulator PerR, in an M1 serotype of Streptococcus pyogenes. To determine the role of PerR in S. pyogenes, we inactivated the gene by allelic replacement. PerR-deficient bacteria showed 48% reductio
Daniel Quinn is the protagonist in Paul Auster's novel City of Glass. This essay traces his development chronologically to assess his search for, need of, and eventual lack of an identity.
Klimatförändringarna tvingar miljontals människor världen över att lämna sina hem, men det juridiska skyddet för dem som flyr miljörelaterade kriser är fortfarande otydligt och fragmenterat. 1951 års flyktingkonvention erbjuder viktiga skydd för personer som flyr förföljelse, men omfattar inte individer som fördrivs av klimatförändringar, vilket skapar betydande luckor i den internationella rättenClimate change is displacing millions globally, yet legal protections for those fleeing environmental crises remain unclear and fragmented. The 1951 Refugee Convention offers critical safeguards for those fleeing persecution but excludes individuals displaced by climate change, leaving significant gaps in international law. This raises pressing questions: How can international law address the chal
Välkommen till Institutionen för hälsovetenskaper, en av sex institutioner vid Medicinska fakulteten, Lunds universitet. Genom vår forskning ökar vi kunskapen och förståelsen om människors hälsa och livskvalitet. Hälsofrämjande och förebyggande insatser, behandlande åtgärder, vård och omsorg och rehabilitering är centrala forskningsområden. Vi arbetar i nära samarbete med hälso- och sjukvård och kThe Department of Health Sciences is one of six departments at the Faculty of Medicine, Lund University. We conduct research within the field of health sciences. Health promotion and prevention efforts, Treatment measures, Health and social care and Rehabilitation are key research areas. We work in close collaboration with health care and municipalities to translate research results into practical
Hjärt-kärlsjukdom är världens vanligaste dödsorsak. Det främsta underliggande tillståndet är ateroskleros: plack som bildas i blodkärlens väggar och kan orsaka akuta komplikationer, såsom hjärtinfarkt och stroke. Genom vår forskning ämnar vi identifiera kliniska metoder som kan hjälpa oss att hitta plack med hög komplikationsrisk, för att i tid kunna ge adekvat förebyggande behandling. Vi vill äveCardiovascular disease is the most common cause of death. The main underlying condition is atherosclerosis: plaques formed in the arteries which can cause complications as stroke or myocardial infarction. Our research aims to prevent complications by identifying clinical methods to detect patients with high-risk plaques to personalize treatment strategies as well as novel mechanisms to use as ther
Existing metastatic disease represents a major clinical challenge. The long-term goal of our study is to gain deeper understanding of cellular mechanisms underlying cancer metastasis. We focus on identification and validation of new predictive biomarkers and drug targets that are specifically for metastatic cancer. We recently focus on studying the role of lipid kinases in particular, phosphatidyl
Drawing on data from the United Kingdom, Sweden, Germany, and Switzerland, this article shows that during the process of interpreting the refugee definition and applying it to the context of the Eritrean Military/National Service Programme (MNSP), the definition is subject to various interpretations and applications. As a result, the treatment of similarly situated Eritrean asylum applications dif
Sektionen Forskning, samverkan och innovation (FSI) omfattar idag fyra avdelningar - LU Innovation, Forskningsservice, Samverkan och Development Office. På sektionen arbetar 86 personer. FSI är också värd för Swelife, Lärosäten Syds kontor i Bryssel samt är länkad till LU Ventures AB. FSI ger stöd till forskare, externa samarbetspartners och ledning i frågor som rör forskningsfinansiering, fin
This paper explores how policy makers argue for the importance of digital competence in Swedish teacher education. A policy analysis of key policy documents from the government and from government-affiliated organisations from the time period 2011–2016 is conducted using Carol Bacchi’s ‘what’s the problem represented to be?’ approach. The paper critically examines underlying assumptions and partic
This volume contains a comprehensive evaluation of the hypthesis that the Gospel of Mark has been influenced by the theology of the apostle Paul. It discusses the history of this view from the nineteenth Century to the modern day, analyses possible historical Connections between the apostle and the evangelist, and compares and contrasts many major theological themes in both the epistles and the Go
AimsTo assess the variation in ovarian carcinoma type diagnosis among gynaecological pathologists from Nordic countries, and whether a rationally designed panel of immunohistochemical markers could improve diagnostic reproducibility. Methods and resultsEight pathologists from four countries (Sweden, Denmark, Norway, and Finland) received an educational lecture on the diagnosis of ovarian carcinoma
Allteftersom stora framsteg görs i datorernas värld och inom artificiell intelligens ser samhället en allt större implementering av artificiell intelligence-teknologi i människors vardag. En sådan implementering är autonoma, självkörande, fordon. Detta är en teknologi som lovar stora framsteg inom fordonssäkerhet, lägre utsläpp till följd av mindre köbildning och en rad andra samhällsvinster. Det
Mervärdeskatterätten utgör ett fullständigt harmoniserat område inom EU och medlemsstaternas lagstiftning på området är till sin helhet baserad på EU rätten. En uniform tillämpning av momsreglerna i medlemsstaterna är av stor vikt för mervärdesskattesystemets funktion. Skyldigheten att tolka nationell lag i enlighet med EU rätten är därför ett viktigt instrument för att säkerställa en uniform tillThe area of VAT constitutes a completely harmonized area within the EU and the national provisions in this area are to their entirety based on EU law. A uniform application of the VAT provisions throughout the EU therefore becomes essential in order to ensure the proper function of the VAT system. The obligation for national courts to interpret national law in conformity with EU law becomes an imp
Aquaporins (AQPs) are membrane channel proteins that transport water and uncharged solutes across different membranes in organisms in all kingdoms of life. In plants, the AQPs can be divided into seven different subfamilies and five of these are present in higher plants. The most recently characterized of these subfamilies is the XIP subfamily, which is found in most dicots but not in monocots. In
Paper presented at Swedish Anthropological Association Annual Meeting, Lund, April 2015, panel on Business ethics. Abstract: Under the influence of U.S. government regulations, new anti-bribery laws and embarrassing corruption scandals, major global corporations have realized that unethical conduct may affect their reputations and ultimately, their profits. This development has given rise to a new
Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other orthoflaviviruses—enveloped, arthropod-borne RNA viruses—host factors required for TBEV entry remain poorly defined. Here we used a genome-scale CRISPR–Cas9-based
