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Genetiskt modifierade T celler, kända som CAR-T celler, fungerar som cancerriktade missiler, utformade för att specifikt lokalisera och eliminera tumörceller. Nuvarande versioner har visat enastående framgång i vissa blodcancerformer, men tyvärr är de ineffektiva i andra cancertyper, såsom solida tumörer och andra blodcancerformer. Denna begränsning härstammar främst från bristen på verkligt canceGenetically modified T cells, known as CAR T cells, function like cancer-targeting missiles, designed to specifically locate and eliminate tumor cells, providing promising prospects for more effective cancer therapies. While current iterations have demonstrated unprecedented success in certain blood cancers, they have proven ineffective in other cancer types, such as solid tumors and various blood

Purpose: The aim of this paper is to find out how the PMM system can be used to remain resilient to a change in the environment and so continue to provide appropriate guidance to managers in real time. Methodology: The paper is based on a qualitative research method with primarily an abductive approach to derive insight about a PMM system’s use to remain resilient to a change in the environment.

• Meliha C Kapetanovic (gruppledare) huvudforskningslinje är att studera olika aspekter av vaccination vid inflammatoriska reumatiska sjukdomar. Andra forskningsområden är remission vid reumatoid artrit och gikt. Doktorander Jon Einarsson, Johanna Nagel and Per Nived är involverade i dessa projekt. • Elisabet Lindqvist Johan K Wallman, Tor Olofsson och Elisabet Mogard (doktorand) ansvarar för SPAR• Meliha C Kapetanovic (group leader) research area includes vaccinations in patients with inflammatory rheumatic diseases, remission in patients with RA and gout. PhD students Jon Einarsson, Johanna Nagel and Per Nived are involved in these projects. • Elisabet Lindqvis’s Johan K Wallman, Tor Olofsson and Elisabet Mogard (physiotherapist, PhD-student) are responsible for SPARTAKUS, a crossectiona

Medicinen är ett kunskapsfält med humanistisk förankring. Vid Enheten för medicinens historia är målet att nå ökad förståelse för hur den medicinska vetenskapen tagit form över tid och fördjupad insikt kring det sociala sammanhang medicinen verkar i. Genom sin tillhörighet i ämnesområdet Medicinsk humaniora gränsar verksamheten till flera andra akademiska discipliner, såsom idé- och lärdomshistori

The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice,

There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less

Aortoenteric fistula formation is a devastating condition regardless of whether it is primary or secondary (i.e. after previous aneurysm repair) in nature. Patients present with signs and symptoms of gastrointestinal bleeding with or without signs of systemic infection and are often in a very poor clinical condition. Conventional treatment consists of extensive open surgery (extra-anatomical bypas