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Effective treatment of haemophilic arthropathy requires a detailed evaluation of joint integrity. Methodological assessment of magnetic resonance imaging (MRI) scores are needed to assure reproducibility of measurements when comparing results of clinical trials conducted in different centres. We compared the reliability of two MRI scoring systems for assessment of haemophilic arthropathy: one prog
BACKGROUND: Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterised by progressive neurological degeneration, where the rate of neurological disease progression varies depending on age at neurological onset. We report longitudinal data on functional disease progression and safety observations in patients in the international NPC Registry who received continuous treatment w
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the
Objective: Women with active sunlight exposure habits experience a lower mortality rate than women who avoid sun exposure; however, they are at an increased risk of skin cancer. We aimed to explore the differences in main causes of death according to sun exposure. Methods: We assessed the differences in sun exposure as a risk factor for all-cause mortality in a competing risk scenario for 29 518 S
Carrier and prenatal diagnosis based on the identification of the gene defect (direct diagnosis) increases the proportion of haemophilia B families that can be offered precise genetic counselling from the 50-60% attainable by DNA markers, to 100%, and they also provide information on the molecular biology of the disease. We propose that in order to maximize the practical and scientific benefits of
Due to human-induced environmental changes, many natural populations are undergoing extensive fitness declines. Natural or sexual selection could potentially shift the phenotypic mean of critical traits towards new phenotypic optima, promoting evolutionary rescue. However, this process has rarely been studied in natural populations. Furthermore, the population fitness can also be increased by gene
This study aims to investigate how girls within SiS special residential homes for youths are constructed in Swedish news media. The study is based on the social constructivist perspective and Yvonne Hirdman's gender theory. The theory choices have been made to make visible how words in news media construct both gender and the overall image of girls within SiS special residential homes for yout
Peru grapples with severe water insecurity due to climate change and ecosystem degradation. In response, the government implemented the Ecosystem Services Compensation Mechanism for Water Security (MERESE), employing Payment for Ecosystem Services to incentivize nature-based solutions. Central to MERESE are Good Governance Platforms, multi-stakeholder bodies overseeing implementation and ensuring
Artificial intelligence (AI) technologies are being widely employed globally to enhance marine safety services and address challenges within the maritime sector. Nevertheless, the provision of these services in East Africa, particularly within the Lake Victoria basin, is deficient and inadequate. Consequently, a study needs to be undertaken to pinpoint certain domains in marine safety that may be
The terms “gender” and “sex” are central to feminist concerns. In English scholarship “gender” is disputed within and outside of feminism, despite its seemingly political correctness as an alternative to “sex” (Olson 2012; Gunnarsson 2011). This thesis aims to describe how “gender”, multi-word expressions with “gender”, and the derivative “gendered” are translated into Arabic target texts (TTs) by
Corporations and in particular large multinational enterprises are important for every countries economic growth. However, exploitation and human rights abuses due to corporate activity are repeatedly occurring in states that lacks the proper legislation, enforcement or institutions to ensure human rights protection. Thus, there is an increasing call for lead firms of MNEs to exercise human rights
With rapid urbanization and an increasing share of anthropogenic greenhouse gas emissions from cities, low-carbon urban transformations are critical for mitigating climate change. Local climate networks have been recognized for their potential to govern such activities. However, less is known about how such networks are implemented and managed as well as their capacity to accelerate transformative
As one of the primary countries of destination for migrant domestic workers in Asia, Singapore is a developed country with one of the highest standards of living in the region. Yet, the city-state has been on the receiving end of extensive criticism concerning the rights and protections of migrant domestic workers. Civil society organizations have been one of the loudest critics, and in recent pub
