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Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment inter
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi
Informetric/bibliometric analyses have to a large extent been relying on an assumption that research is essentially cumulative in its nature, which is not the least visible in the rational for using citation analyses to assess quality of research. However, when reviewing both the theoretical literature on how research is organized and studies analyzing the structures of research fields through inf
The variations in functional capacity, life quality and health increase as people grow older. Most likely, this is the result of a lifelong process in which both "wear-and-tear" and constructive development play a major role. Life experiences all the way from daily hazards to burdensome life events, to long-term exposure, to stress and strain might wear out the body. Life experiences of self-fulfi
Vind har blivit en alltmer accepterad källa till förnyelsebar energi och utnyttjas idag världen över. Vindenergi har fördelen av nästintill inga utsläpp av växthusgaser, men allmänheten har i vissa uttryckt oro över det buller som associeras med vindkraftverk. For att möta detta missnöje har kommuner infört föreskrifter som begränsar ljudnivåerna vid bostadshus belägna i närheten av vindkraftverk.Wind has become an increasingly accepted source of renewable energy and is currently exploited worldwide. Wind energy has the advantage of close to zero green-house gas emissions, however one of the key concerns the public has about wind farm development is noise emissions. To address these local governments have introduced noise regulations, which limit noise levels at residential buildings locat
The Nordic countries offer an ideal case study of the COVID-19 pandemic due to their comparability, high data quality, and variable mitigations. We investigated the age- and sex-specific mortality patterns during 2020–2021 for the five Nordic countries and analysed the total age- and sex-adjusted excess deaths, ratios of actual to expected death rates, and age-standardized excess death estimates.
The Last Interglacial (LIG) experienced substantial changes in seasonal insolation compared with the present day, which may have affected the hydrography and water-mass exchange in the North Sea and Baltic Sea region. Here we investigate the effects of solar radiation and greenhouse gas (GHG) forcing on the regional climate by analyzing model simulations of the LIG (127 ka BP), pre-industrial (PI,
This article examines the portrayal of bodily boundaries in the videogame series The Last of Us. Drawing on theories of media ecology and posthumanism (most notably Deer’s notion of radical animism, Haraway’s theories of the cyborg, and Fuller’s account of media assemblages), three aspects of this portrayal are described: first, the game’s narrativization of bodily violence through an amalgamation
Resonant photoelectron spectroscopy (RPES) has been used to probe electronic structure properties of the closed-shell [FeII(CN)6]4− and open-shell [FeIII(CN)6]3− prototype transition metal complexes in aqueous solution. Site-selective Fe 2p (L-edge) RPES mapsprovide new insight into spin-coupling processes at the core-excited metal centers, with autoionization of [FeIII(CN)6]3− showing a dramatic
Processes controlling environmental change in the subarctic Pacific Ocean on millennial to orbital timescales are not well understood. Here we use a 230-kyr sedimentary record from the northwest Pacific Ocean to assess the response of late Pleistocene sediment dynamics to orbital forcing. Combining a source-to-sink perspective based on sedimentological records with climate model reanalysis, we rev
As global warming is proceeding due to rising greenhouse gas concentrations, the Earth system moves towards climate states that challenge adaptation. Past Earth system states are offering possible modelling systems for the global warming of the coming decades. These include the climate of the mid-Pliocene (∼ 3 Ma), the last interglacial (∼ 129-116 ka) and the mid-Holocene (∼ 6 ka). The simulations
Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates
Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR
Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women
α-Synuclein (α-syn) is an intrinsically disordered protein with a highly asymmetric charge distribution, whose aggregation is linked to Parkinson’s disease. The effect of ionic strength was investigated at mildly acidic pH (5.5) in the presence of catalytic surfaces in the form of α-syn seeds or anionic lipid vesicles using thioflavin T fluorescence measurements. Similar trends were observed with
