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Electron paramagnetic resonance (EPR) studies of succinate:ubiquinone oxidoreductase (SQR) from Paracoccus denitrificans have been undertaken in the purified and membrane-bound states, Spectroscopic ''signatures'' accounting for the three iron-sulfur clusters (2Fe-2S, 3Fe-4S, and 4Fe-4S), cytochrome b, flavin, and protein-bound ubisemiquinone radicals have been obtained in air-oxidized, succinate-
A measurement of the production cross section for two isolated photons in proton-proton collisions at a center-of-mass energy of s=8 TeV is presented. The results are based on an integrated luminosity of 20.2 fb-1 recorded by the ATLAS detector at the Large Hadron Collider. The measurement considers photons with pseudorapidities satisfying |ηγ|40 GeV and ET,2γ>30 GeV for the two leading photons or
A search for squarks and gluinos in final states containing hadronic jets, missing transverse momentum but no electrons or muons is presented. The data were recorded in 2015 by the ATLAS experiment in √s = 13 TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation was observed in 3.2 fb−1 of analyzed data. Results are interpreted within
Aim: Complement-mediated atypical haemolytic uraemic syndrome (aHUS) is a rare disease with high mortality and morbidity if left untreated. The diagnostic work-up is complicated and the manifestations overlap with other conditions. Therefore, we hypothesize that complement-mediated aHUS is an under diagnosed disease. Methods: A cohort of 768 referrals referred to the Coagulation Unit in Malmo, Swe
This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To summarize the evidence from systematic reviews regarding the effects and safety of pharmacological interventions related to pain and sedation management in order to prevent GMH-IVH in ventilated preterm infants.
Objective: Experimental findings and previous observational data have suggested lower risk of osteoarthritis (OA) with statin use but results are inconsistent. Large-scale studies with a clinically important outcome are needed. Thus, we aimed to determine whether statin use is associated with a reduced risk of developing clinically-defined hip or knee OA. Design: Pooled analysis based on time-to-e
A search for new phenomena in final states characterized by high jet multiplicity, an isolated lepton (electron or muon) and either zero or at least three b-tagged jets is presented. The search uses 36.1 fb−1 of s=13 TeV proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider in 2015 and 2016. The dominant sources of background are estimated using parameterized
Dijet events are studied in the proton-proton collision data set recorded at s=13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016, corresponding to integrated luminosities of 3.5 fb-1 and 33.5 fb-1 respectively. Invariant mass and angular distributions are compared to background predictions and no significant deviation is observed. For resonance searches, a new method for
he study purpose is to determine whether numeric and/or graphic ST measurements added to the display of the 12-lead electrocardiogram (ECG) would influence cardiologists' decision to provide myocardial reperfusion therapy. Twenty ECGs with borderline ST-segment deviation during elective percutaneous coronary intervention and 10 controls before balloon inflation were included. Only 5 of the 20 ECGs
Abstract We present a practical protocol for the assignment of values to serum proteins in a Target Material using a Reference Material. This protocol is based on the model of Direct Value Transfer between serum matrices and is intended to improve the value assignment of commercial calibrators using the Reference Material CRM 470 (now labeled ERM-DA 470) or similar reference materials. The procedu
PURPOSE: Several inherited corneal disorders in humans result from mutations in the transforming growth factor beta induced gene (TGFBI), which encodes for the extracellular transforming growth factor beta induced protein (TGFBIp) that is one of the most abundant proteins in the cornea. We previously reported a significant amount of TGFBIp in plasma by immunoblotting using the only TGFBIp antiseru
Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood. Here, we show that up-regulation of the polyamine system promotes cancer cell survival during hypoxic stress. Hypoxia was found to induce polyamine transport and the key enzyme of
The one-dimensional inverse scattering problem for inhomogeneous lossy media is considered. The model problem involves electromagnetic wave propagation in a medium of unknown thickness with spatially varying conductivity and permittivity. Two inversion algorithms are developed in the time domain using data obtained from normally incident plane waves. These algorithms utilize reflection data from b
Background: With the availability of a wrist-worn device capable of acquiring two ECG leads with a single touch, synthesis of the 12-lead ECG may be accomplished to facilitate clinical interpretation. Objective: This study proposes an echo state network (ESN) for synthesizing the 12-lead ECG from two leads simultaneously acquired using a wrist-worn device. Methods: The wrist-worn device, equipped
Effluent wastewater contains organic micropollutants (OMPs) that harm aquatic ecosystems. Therefore, wastewater treatment plants (WWTPs) need to expand their facilities with advanced water treatment technologies. Water scarcity and improved effluent quality is encouraging the reuse of treated effluent. This study thus has a dual purpose: first, to evaluate OMP removal using two technique combinati
Purpose: A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer treated with definitive radiation, using biopsy digital pathology images and key clinical information (age, PSA, and T-stage) to generate prognostic scores. This study externally validates the biomarker in a prospective, real-world dataset of
Although high-level evidence is currently lacking, noninferiority randomised controlled trials in predefined risk groups in non-muscle-invasive bladder cancer are under way to scientifically prove the safety of urinary biomarker-guided follow-up. To facilitate recommendations for clinical use, it is essential to comply with the EU certification for in vitro diagnostics and to demonstrate cost effe
A search is reported for long-lived dark photons with masses between 0.1 GeV and 15 GeV, from exotic decays of Higgs bosons produced via vector-boson-fusion. Events that contain displaced collimated Standard Model fermions reconstructed in the calorimeter or muon spectrometer are probed. This search uses the full LHC Run 2 (2015–2018) data sample collected in proton–proton collisions at s=13 TeV,
