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The Amazonian Craton is host to one of Earth’s largest Proterozoic silicic large igneous provinces (SLIPs), the Orocaima SLIP (ca. 1.98 Ga). Nevertheless, the mechanism(s) responsible for this large-flux felsic magmatic event and its relationships with regional tectonics and/or mantle processes remain debated. New geochronologic and geochemical results from multiple mafic dike swarms in the Amazon
BackgroundAmyloid-β peptides (Aβ) applied to Alzheimer's disease (AD) brain bind to amyloid plaques (APs) and this binding is saturable. Meanwhile, anti-immunoglobulin G (IgG) antibodies label APs. Considering the saturable binding of Aβ to APs and the localization of IgGs in APs, specific binding proteins (BPs) for the applied Aβ could be anti-Aβ IgG antibodies (anti-AβAbs) in APs.ObjectiveOur ob
In a world where the challenges of climate change, social inequality, economic instability, and geopolitical tensions are ever-present, educators have a unique opportunity—and responsibility—to prepare their students to navigate these complexities. However, educators are also juggling teaching and research, competing deadlines, shifting expectations, institutional paradigms, and limited time and s
Li-rich nickel cobalt manganese oxides (LNCM) cathode with full gradient compounds is prepared by using an ethanol assisted co-precipitation method. The rationally designed procedure involves gradient distributions of transition-metal ions, in which the Ni content increases continuously, Mn content decreases gradually and Co keeps at a low level. The employing ethanol during the synthesis adjusts
In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy vo
Electrospun nanofiber membranes (ENMs) with unique porous 3D network structure exhibit properties such as high porosity and surface area, fine-tuned surface functionality and uniform pore sizes. This makes them candidates for water/wastewater applications with excellent flow. This study focuses on the fabrication of polymeric and composite ENMs from polyacrylonitrile (PAN) and nanoclay (NC) and th
The question of the legal permissibility of heritable gene editing techniques is unsettled. The international consensus opposes clinical research and applications involving germline modifications. Building on previous work, this paper examines how international human rights law, particularly human right to science standards, can inform the regulation of this controversial advancement. We present t
Abstract: Diffusion-weighted imaging (DWI) offers critical insights into tissue microstructure through the assessment of water molecule random displacements and plays a central role in the assessment of neoplastic and non-neoplastic diseases. To successfully implement and use DWI in clinical practice, guidelines for acquisition, interpretation of image contrast and of artefacts should be followed,
Purpose: The Workplace Dialogue is a digitalized method directed at managers. The purpose of this study was to explore managers’ experiences of using the digital Workplace Dialogue in cases of employee ill-health. Design/methodology/approach: The Workplace Dialogue provides an easy and accessible method for managers, including text, short films, client examples and concrete guides that provides su
Indigenous archaeology and archaeology of Indigeneity are paramount in the contemporary world. We certainly need more of it across the archaeological scale and across the archaeological globe. Archaeology’s unhealthy attachment to colonialism, colonial administration and imperialism keeps on affecting our discipline on all levels. It is therefore encouraging to read Felix Acuto’s call for an engag
AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab
The world has encountered numerous global crises, including epidemics, military conflicts, and economic collapse. Innovative digital technologies, such as Industry 4.0 (I4.0), can undoubtedly help improve industries’ operations during critical times. The dairy industry has seen an increment in technological adoption in the last few years. Adopting cutting-edge technologies is regarded as more feas
This study provides an in-depth analysis of the impact of a multimodal journey-planning app on users of informal public transport systems in Cochabamba, Bolivia. We analyze survey data (N=648) collected through the Trufi Association NGO's digital travel app on changes in mobility behavior, satisfaction, and everyday life improvements. Participants report more frequent use of informal transport (49
Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameter
Decarbonising the built environment is essential to mitigating the climate crisis, as buildings significantly contribute to greenhouse gas emissions. Adaptive reuse presents a sustainable alternative to demolition and new construction. This study evaluated the Global Warming Potential (GWP) of an adapted building through renovation and operation across three scenarios, compared to a reference scen
This paper examines forest-based bioeconomy innovation in Sweden between 1970 and 2021 to test central claims about innovation complexity, knowledge requirements, collaboration intensity, and industrial life cycle dynamics. Using a comprehensive database of 4,972 commercialized innovations, I identify 649 forest bioeconomy innovations and analyze their characteristics through logistic regression,
