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This thesis discusses a rather contentious issue of how copyright law possesses musical works nowadays. It is essentially argued in the thesis that current copyright law appears to be too restrictive, leaving not enough space for creativity in the musical world. In this regard, the issue related to musical works are mainly analysed through the prism of the idea-expression dichotomy. One of the gen
In adaptive deep brain stimulation, a treatment for motor symptoms in Parkinson’s disease, the target of the stimulus is usually in the sub-thalamic nucleus or the globus pallidus. In this thesis, a new stimulus target called reticular thalamus is investigated in a rat model of Parkinson’s disease. The responses to the stimulus were recorded from both local field potentials and action potentials f
Streptomyces species are filamentous bacteria from the phylum Actinobacteria in which cell elongation occurs at the poles of the cell. This differs from many other bacteria like Escherichia coli where cell elongation occurs by insertion of peptidoglycan in the lateral wall. An essential protein for polar growth in Streptomyces is the coil-coiled protein DivIVA. DivIVA has an essential role in orch
Background/purpose Quantitative susceptibility mapping (QSM) is an MRI-based post processing technique to evaluate the magnetic susceptibility, χ, of human tissue using phase data. While brain imaging has been the most common application, other areas have also raised interest. For example, QSM of the articular cartilage of the knee has been suggested as a means to study the degeneration of this ti
In 2021, the Icelandic government stated that Iceland will implement an energy transition plan with the goal of becoming a 100% carbon neutral and fossil free nation by 2040, furthermore, that a doubling in renewable energy production was needed to reach that goal. This led to an upsurge of a discourse among stakeholders and concerned citizens about the future of Iceland. This thesis is an attempt
In this master’s thesis, different options to update the variant rank model used at the University hospital in Lund are presented. The variant rank model filters genetic variants from whole genome sequencing. This is done to identify potential causative variants in patients. Since the knowledge concerning these variants and rare genetic diseases grows rapidly, the model which filters said variants
Streamflow analysis helps us understand the availability of water resources in a region or a river. Accurate and timely streamflow monitoring is essential to improve our understanding of the hydrological cycle. Streamflow information is also necessary for many applications, such as irrigation planning, watershed management, hydropower products, flood control, and integrated water resources managem
Spatial data is an important and necessary ingredient in the disaster management cycle. The preparedness phase requires simulation of disastrous events, identification of disaster management hotspots and creation of hazard- and risk maps. A rapid response in the event of a disaster requires good situational awareness and fast sharing of that knowledge across the community. Further, in the recovery
In most manufacturing companies, it is necessary to carry inventory to a greater or lesser extent in order to disconnect the activities in the supply chain that are not conducted at the same pace. This way, a smoother flow through the chain, from raw material extraction to arrival at the final customer of a finished product, is facilitated. However, different parts of a company often have conflict
Earth system models (ESMs) are key tools for providing climate projections under different scenarios of human-induced forcing. ESMs include a large number of additional processes and feedbacks such as biogeochemical cycles that traditional physical climate models do not consider. Yet, some processes such as cloud dynamics and ecosystem functional response still have fairly high uncertainties. In t
One way of valorizing the lignin waste stream from the pulp and paper industries is depolymerizing it into low-molecular-mass compounds (LMMC). However, a common problem in the depolymerization of Kraft lignin is the low yields of small aromatic molecules obtained. In the present work, the combination of the repeated depolymerization of lignin and the separation of LMMC from depolymerized lignin t
Kindling, induced by repeated subconvulsive electrical or chemical stimulations leads to progressive and permanent amplification of seizure activity, culminating in generalized seizures. We report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase of mRNA for NGF and BDNF in the dentate gyrus, the parietal cortex, and the piriform co
A simple and sensitive immunoradiometric assay for the detection of islet cell surface antibodies (CIRMA) has been developed. Live, transformed islet cells derived from a liver metastasis of a transplantable islet cell tumor were grown in removable microtiter wells and incubated with antibody. Cell-bound antibodies were quantitated using 125I-labelled second antibodies. The assay was used to detec
Polymer films based on mixtures of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) have been widely used to coat pellets and tablets to modify the release profile of drugs. For three different EC/HPC films we used 1H and 19F MRI in combination with a designed release cell to monitor the drug, polymer and water in 5 dimensional (5D) datasets; three spatial, one diffusion or relaxation and a
The loss of p53 induces spontaneous tumors in mice, and p53 mutations are found in approximately 50% of human tumors. These tumors are generally caused by a number of events, including genomic instability, checkpoint defects, mitotic defects, deregulation of transcriptional targets, impaired apoptosis, and G 1 deregulation or a combination of these effects. In order to determine the role of protei
The G1/S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb) have been studied in separate animal models, but interactions between the kinases and Rb in vivo have yet to be investigated. To further dissect the regulation of the G1 to S-phase progression, we generated Cdk2-/-Cdk4-/-Rb-/- (TKO) mutant mic
A polymer electrolyte fuel cell (PEFC) produces electrical energy according to the electrochemical reactions carried out inside the cell. During the energy conversion, water molecules are also produced at the cathode side, which affects the gas diffusion layer (GDL) diffusion parameters. The generated water-drops from the reaction may give partial or total blockage of the reactant gases and also m
