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Enantioselective synthesis is an important research topic with applications in drug development. Asymmetrical catalysis is one of the available ways of producing enantioenriched products. C2-Symmetric dibenzo[a,e]cyclooctenes or dbCOTs are a family of versatile chiral ligands for transition metals. They display great efficiency and enantioselectivity in 1,2- and 1,4- additions reactions. In this

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Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E