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Abstract Parkinson’s disease (PD) is characterized by selective loss of dopaminergic neurons and progressive accumulation of intracellular alpha synuclein protein aggregates known as Lewy bodies. Due to pathological links to both sporadic and inherited cases of PD, alpha synuclein (asyn) has become a focal point for study, although the exact mechanisms of its toxicity are not known. In contrast to
This thesis is focusing on the protection of fundamental human rights at work for third country migrant workers in the European Union, a region which attracts more and more migrant workers in recent years. The first Chapter introduces the background briefly, the methodology and the sources on which the research is conducted on and provides the scope and definition of the issues which are under dis
Asylum seekers and refugees are one of the most demonised and marginalised social groups in Europe. Ireland's current agenda for dealing with refugees and asylum seekers is inadequate. The government of Ireland is aware of the inadequacy of response and has proposed to make a number of changes that will improve the standard of living for those who chose to apply for inclusion in Ireland. Howev
A need for autonomous electro-mechanical machines performing tasks that can save human efforts and even be deployed in hazardous environments along with the research in the field of human mind and body has led to new fields often called AI Robotics. To provide a mean for stimulating students and researchers around the world for promotion of this new field, an annual world championship, Robocup, ha
Som en effekt av den globala strävan som syftar till att motverka klimatförändringar som tillskrivs ökande koldioxidnivåer i atmosfären försöker man hitta okonventionella sätt att minska koldioxidutsläpp. CCS anses vara en metod med stor potential för detta syfte vilket har föranlett en världsomspännande prospektering av platser som kan användas för geologiskt lagring av koldioxid. Detta arbete As a part of a global attempt to mitigate impending climate change owing to increasing atmospheric CO₂levels unconventional methods which may reduce CO₂ emissions are extensively researched. Carbon Capture and Storage,(CCS) is considered to be a promising method for this purpose. As a consequence, worldwide prospection of geological sites in which CO₂ may be stored is currently underway. This th
The mass production of plug-in electric vehicles (PEVs) is expected to start in the coming years. Climate change, peak oil and the automotive and economic crisis have put a significant pressure on the current transportation regime. Increasing urbanisation, range and efficiency advantages of PEVs in city traffic and the problem of urban air pollution have moved cities into the focus of PEV dissemin
One of the best systems for exploring the origin of enzyme catalysis has been the reaction of ketosteroid isomerase (KSI). Studies of the binding of phenolates to KSI have been taken as proof that the electrostatic preorganization effect only makes a minor contribution to the binding of the real, multiring, transition state (TS). However, our simulation study has determined that the difference bet
Purpose: There is a need for a simple, non-invasive, and easily accessible 3D imaging technique for the anophthalmic socket to create imaging data for future 3D printing of prostheses. This study aimed to investigate the feasibility of using a novel handheld tomographic ultrasound for 3D mapping of the anophthalmic socket. Methods: Ten anophthalmic sockets were scanned using a tomographic ultrasou
Background: Preterm and low birth weight infants are at an early stage of development, and do not receive adequate maternal circadian signals. They are often cared for over prolonged periods of hospitalisation in neonatal intensive care units (NICU), where environmental circadian stimuli are lacking. Exposure to artificial light–dark cycles may stimulate the development of the circadian system and
In many countries, practice-oriented programs have been recast as university programs, fueling debate on the purpose of higher education. We highlight two ways of talking about the challenges for higher education we think are already familiar to readers. We label them ‘political-worry discourse’ and ‘academic-worry discourse’. We argue for a third position that gives due recognition to the turn in
We investigate the enrichment patterns of several delivery scenarios of the volatiles to the atmospheres of ice giants, having in mind that the only well constrained determination made remotely, namely the carbon abundance measurement, suggests that their envelopes possess highly supersolar metallicities, i.e., close to two orders of magnitude above that of the protosolar nebula. In the framework
Large multiobject spectroscopic surveys require automated algorithms to optimize their observing strategy. One of the most ambitious upcoming spectroscopic surveys is the 4MOST survey. The 4MOST survey facility is a fibre-fed spectroscopic instrument on the VISTA telescope with a large enough field of view to survey a large fraction of the southern sky within a few years. Several Galactic and extr
In this work, atmospheric pollutant emissions of NOx, SOx, CO, particulate matter (PM), total organic compounds (TOC), and CO2 from larger stationary sources of pollutants in Brazil were inventoried and spatialized over the whole Brazilian territory for the base year 2011. The developed inventory comprises a total of 16 refining units, 1730 thermoelectric power plants (TPPs), 96 cement industries,
Climate change researchers argue that a residual domain exists beyond the limits of adaptation to prevent deleterious climate change impacts: this has been labeled as “loss and damage.” Over the last 8 years, there has been significant growth in loss and damage scholarship thus making it imperative to take stock of what we know already and directions for future research. We undertook a quantitativ
Radical energy efficiency improvements are needed to keep global warming within 1.5 °C until the end of the century. Minimum energy performance standards (MEPS) are a widely applied policy instrument to improve the energy efficiency of appliances and reduce CO2 emissions, but they are criticized as redundant if an overarching carbon pricing scheme is in place. In order to better understand how MEP
Post-compression of (sub)-picosecond laser pulses down to sub-100 fs durations has become a standard approach for high-peak-power sources at a high average power [1]. Here, we propose a new post-compression geometry suited for extreme temporal compression of energetic narrowband lasers, such as diode or electrically pumped four-level systems which can deliver kW-average powers [2], but typically e
