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The Advanced Light Source (ALS) at Berkeley Lab has seen many upgrades over the years, keeping it one of the brightest sources for soft x-rays worldwide. Recent developments in magnet and vacuum technology, as well as lattice design (multi bend achromat lattices) appear to open the door for very large further increases in brightness [1]. This could be achieved by reducing the horizontal emittance,
The intensification of agricultural practices throughout the twentieth century has had large detrimental effects on biodiversity and these are likely to increase as the human population rises, with consequent pressure on land. To offset these negative impacts, agri-environment schemes have been widely implemented, offering financial incentives for land-owners to create or maintain favourable habit
This chapter presents a case study of how Accus, a small Swedish company, worked on developing a circular business model for light sign production and installation to become more sustainable. Drawing on Actor Network Theory (ANT), the Accus case shows that circular business model development is a cooperative endeavor that rests on bringing together a large and changing array of human, as well as n
The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of
Purpose: The purpose of this paper is to elaborate on how perspectives and assumptions embedded in the complexity paradigm contribute to make logistics management research better aligned with real-life logistics. This is necessary, due to increasing supply chain complexity caused by an increasing request for sustainable development (SD). Design/methodology/approach: The research is exploratory and
The minimum weighted edge dominating set problem (MWEDS) generalizes both the weighted vertex cover problem and the problem of covering the edges of graph by a minimum cost set of both vertices and edges. In this paper, we propose a meta heuristic approach based on genetic algorithm and local search to solve the MWEDS problem. Therefore, the proposed method is considered as a memetic search algori
Lawrence Summers produced a big upset within the economics profession when he revived Alvin Hansen’s theory of secular stagnation, which had been thought of as an old-Keynesian fallacy. While some economists like Brad DeLong and Paul Krugman instantly recognized Summers’s contribution, a large share of the economics profession remained skeptical at first. Whereas most New Keynesian models allow fo
Total scattering and pair distribution function (PDF) analysis has created new insights that traditional powder diffraction methods have been unable to achieve in understanding the local structures of materials exhibiting disorder or complex nanostructures. Care must be taken in such analyses as subtle and discrete features in the PDF can easily be artefacts generated in the measurement process, w
Fluid transport in the perivascular space by the glia-lymphatic (glymphatic) system is important for the removal of solutes from the brain parenchyma, including peptides such as amyloid-beta which are implicated in the pathogenesis of Alzheimer’s disease. The glymphatic system is highly active in the sleep state and under the influence of certain of anaesthetics, while it is suppressed in the awak
The validation of an evacuation model is generally performed through testing its predictive capabilities within a set of standard environments (e.g. buildings) or standard layouts. Unfortunately, non-expert users could consider model results as reliable in unique environments as well, such as road tunnels, and extend their use to applications where no ad hoc validation tests have been performed. T
There is increasing concern about the emerging global non-communicable diseases (NCDs) burden. The focus has mainly been on NCDs in adults but it is important that MSK morbidity in both children and adults is included in strategic planning. There have been considerable advances in the understanding and treatment options for children and young people (CYP) and clinical outcomes are improving for th
The objective of this study was to critically assess and review empirical evidence on the cost-effectiveness of Mobile Health (mHealth) interventions for older adults. We systematically searched databases such as Pubmed, Scopus, and Cumulative Index to Nursing and Allied Literature (CINAHL) for peer-reviewed economic evaluations published in English from 2007 to 2018. We extracted data on methods
Based on measurements of mould in 17 attics in the north of Sweden, 3 were chosen as a tentative validation of the MRD-model (Mould Resistance Design) for long periods of time (1961-2012). Comparing the measurements and the results from the simulations showed great differences regarding the mould growth depending on the simplifications used in the model. How the leakage was simulated and where the
Purpose: The hippocampus is affected by tau pathology early in Alzheimer's disease (AD) development. Accurate quantification of hippocampal tau signal using the tau-PET tracer 18F-flortaucipir is complicated, however, by off-target binding in the adjacent choroid plexus. We here present a new method for compensating for this off-target choroid plexus signal. Methods: As off-target binding in the c
A detailed study has been made of the method for labeling streptokinase with 99Tc(m) in order to get a radioactive indicator for rapid scintigraphic visualization of thrombi and emboli. The best method found for preparing 99Tc(m) streptokinase was by reducing 99Tc(m) pertechnetate with 2 μmole SnCl2 at pH 0.7 and then adding 50,000 to 75,000 IU of streptokinase at a final pH of about 2. After 1 hr
We analyse the performance of risk reduction strategies for terrorist attacks with Improvised Explosive Devices (IEDs) for large governmental building structures in terms of cost-efficiency, significance and effectiveness accounting for life safety in conjunction with societal preferences and capabilities. The approach builds upon an extended Bayesian pre-posterior decision analysis and the princi
The presence or absence of intermediate-mass black holes (IMBHs) at the centre of Milky Way globular clusters (GCs) is still an open question. This is due to either observational restrictions or limitations in the dynamical modelling method; in this work, we explore the latter. Using a sample of high-end Monte Carlo simulations of GCs, with and without a central IMBH, we study the limitations of s
High diagnostic efficiency as well as the optimization of patient and staff doses in positron emission tomography (PET) can be achieved by implementing quality assurance program. This study was focused on the requirements and basic aspects of quality assurance (QA) in PET combined with computed tomography (CT), that include equipment quality control (QC). QA systems include methods of image QC, ex
The transitions between developmental stages are critical points in the Plasmodium life cycle. The development of Plasmodium in the livers of their mammalian hosts bridges malaria transmission and the onset of clinical symptoms elicited by red blood cell infection. The egress of Plasmodium parasites from the liver must be a carefully orchestrated process to ensure a successful switch to the blood
