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Timely regulation of phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] abundance in cells is essential for the control of cellular homeostasis. The concentrations of these lipids are low in quiescent cells but rapidly and transiently increase following growth factor receptor (GFR) stimulation, which triggers cellular metabolic changes, pro
Under anaerobic conditions, Saccharomyces cerevisiae uses NADH-dependent glycerol-3-phosphate dehydrogenase (Gpd1p and Gpd2p) to re-oxidize excess NADH, yielding substantial amounts of glycerol. In a Δgpd1 Δgpd2 double-null mutant, the necessary NAD+ regeneration through glycerol production is no longer possible, and this mutant does not grow under anaerobic conditions. The excess NADH formed can
Production of polyhydroxyalkanoates (PHA) by an open mixed culture enriched in glycogen accumulating organisms (GAOs) under alternating anaerobic-aerobic conditions with acetate as carbon source was investigated. The culture exhibited a stable enrichment performance over the 450 day operating period with regards to phenotypic behavior and microbial community structure. Candidatus Competibacter pho
Let Ω be a B-regular domain in ℂn and let V be a locally irreducible analytic variety in Ω. Given a continuous function , we prove that there is a unique maximal plurisubharmonic function u on V with boundary values given by ϕ and furthermore that u is continuous on .
With today’s rapid changes in socio-economy and technology, knowledge and learning are critical issues for private and civil service organizations. The needs for competence development range from short informal courses (without ECTS credits) to formal courses at university level (with ECTS credits). This article describes objectives and results of a Leonardo project, eGIS+ that developed and imple
It is often suggested that the emittance coupling of a storage ring should be adjusted to the so-called diffraction limit corresponding to the shortest wavelength of interest. For 1 Å radiation this leads to a typical requirement of 8 pm rad vertical emittance. In ultralow-emittance storage rings like the MAX IV 3 GeV storage ring this corresponds to a comparably large setting of the emittance cou
The last ten years have seen a sharp increase in externally supported capacity development initiatives for disaster risk management. However, not all of them have generated sustainable results. The purpose of this paper is to scrutinize the current focus on training as the main tool for capacity development in the context of disaster risk management, and to argue for the necessity to address capac
The use of prosthetic hands are limited partly due to the fact that they lack the provision of sensory feedback to the user. A first step to providing sensory feedback is having adequate sensors in the prosthesis. The WiseSkin project targets the use of artificial skin embedding ultra-low power wireless sensor nodes. This paper provides an overview of the WiseSkin artificial skin for tactile prost
a) The use of a solid phase reaction (silver silicate) for avoiding ortho ester formation in some difficult glycosyl donor/acceptor systems. Thus seven monodeoxygenated analogues of 2-(Trimethylsilyl)ethyl betha-lactoside were synthesiszed. Silver silcate was successfully used in betha 1-4 coupling of 2- and 3-deoxy glucosides to to acetobromogalactose. By similar means, the monodeoxylactosyl brom
Energy efficiency scenarios are developed in the national and international context to explore and evaluate different policy designs and visions of how energy will be generated, distributed and used in the future. However, these scenarios are often developed using conventional bottom-up modelling tools that, to only a limited extent, take into account decentralised decision-making frameworks, such
Hydrogenolysis of biodiesel-derived glycerol to value-added chemicals has emerged as an innovative approach to biowaste valorization for a more sustainable society. In the present work, Ru catalysts on Al2O3/AlF3 supports with different AlF3 content were prepared by the aqueous incipient wetness method and tested in the reaction of glycerol hydrogenolysis for the first time. The prepared catalysts
This article presents the addition of camber to a previously published semi-empirical tyre model by the same authors. The model combines empirical models for pure braking, cornering and cambering with a model for simultaneous braking, cornering and cambering. It is based on brush-model tyre mechanics and aims to offer an easy-to-use accurate model for vehicle-handling simulations. The proposed mod
Materials having bimodal grain structures are known for the good balance of strength and ductility. However, methods for their fabrication often lack the control of such structure characteristics. In this work, the principles of "harmonic" structure fabrication allowing to control both topology and scale of the bimodal structure heterogeneity have been concisely formulated. The feasibility to form
Subband adaptive filters have been proposed to speed up the convergence and to lower the computational complexity of time domain adaptive filters. However, subband processing causes signal degradations due to aliasing effects and amplitude distortions. This problem is unavoidable due to further filtering operations in subbands. In this paper, the problem of aliasing effect and amplitude distortion
We introduce a general decomposition method applicable to all forms of bivariate rank dependent indices of socioeconomic inequality in health, including the concentration index. The technique is based on recentered influence function regression and requires only the application of OLS to a transformed variable with similar interpretation. Our method requires few identifying assumptions to yield va
In the quest for deciphering disease-associated biomarkers, high-performing tools for multiplexed protein expression profiling of crude clinical samples will be crucial. Affinity proteomics, mainly represented by antibody-based microarrays, have during recent years been established as a proteomic tool providing unique opportunities for parallelized protein expression profiling. But despite the pro
