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This study presents a 2-yr follow-up of 281 patients, aged 15-34 yr, diagnosed with diabetes between 1992 and 1993. At diagnosis, 224 (80%) patients were positive for at least one of the following autoantibodies: islet cell antibodies (ICAs), glutamic acid decarboxylase antibodies (GADAs), or tyrosine phosphatase antibodies (IA-2As); the remaining 57 (20%) patients were negative for all three auto
Hailed by economists as an idea whose time has come, the `new economic geography' has not been quite as favourably received by geographers. Frequently seen as a prime case of academic imperialism, few appear willing to concede that economists may have something to contribute to economic geography. Conversely, beyond the token reference to vintage publications, economistsoften dismiss geographers'
In the present study the inflammatory response was quantitatively evaluated during peripheral nerve regeneration. The fluid from silicone nerve regeneration chambers, inserted in rats, was collected during the early period of regeneration of transected sciatic nerves (6 h-7 d) and analysed with respect to inflammatory cells and mediators (leukotriene B4, LTB4, and interleukin-1 alpha, IL-1 alpha).
The reassigned spectrogram can be used to improve the readability of a time-frequency representation of a non-stationary and multi-component signal. However for transient signals the reassignment needs to be adapted in order to achieve good localisation of the signal components. One approach is to scale the reassignment. This paper shows that by adapting the shape of the time window used with the
The emission of floral volatiles requires coordinated expression of biosynthetic genes. In the regulatory network of the volatile benzenoid/phenylpropanoid pathway in Petunia hybrida two master regulators of the pathway have been identified. The R2R3-MYB transcription factor EMISSION OF BENZENOIDS II (EOBII) utilizes a specific MYB binding site to activate the expression of the R2R3-MYB ODORANT1 (
The health and productivity of global land resources are declining, while demand for those resources is increasing. The aim of land degradation neutrality (LDN) is to maintain or enhance land-based natural capital and its associated ecosystem services. The Scientific Conceptual Framework for Land Degradation Neutrality has been developed to provide a scientific approach to planning, implementing a
The Crafoord Prize in Polyarthritis ranks as one of the most prestigious prizes and can be awarded only if the Royal Swedish Academy of Sciences decides the likelihood of prize worthy progress in the field, and at most every 4th year. This has happened only four times since 1982. This year the 5th Laureates were Shimon Sakaguchi, Fred Ramsdell, and Alexander Rudensky with the motivation "for their
Doctoral education in medicine, engineering, technology and science (METS) is in many ways different from doctoral education in the humanities or social sciences. In the METS disciplines, typically, students and supervisors work and publish together within the supervisors’ research projects. The projects are usually financed by the supervisors’ research grants and their success, in terms of high q
Background: Severity of the primary unilateral cleft lip/nose deformity (UCL/N) is postulated to play a key role in postoperative complications, aesthetic result, and need for secondary surgery. There is no validated and widely accepted classification scheme of initial cleft severity. The purpose of this study was to validate the Unilateral Cleft Lip Cleft Severity Index as a reliable tool for eva
Objective: Adult-onset IgA vasculitis (Henoch-Schönlein) (IgAV) is a rare systemic vasculitis characterized by IgA1-dominant deposits. The treatment of adult-onset IgAV is controversial and is based on the combination of glucocorticoids and immunosuppressive agents, but many patients have refractory or relapsing disease despite treatment. Rituximab (RTX) is a B cell–depleting antibody of proven ef
Transition narratives are stories promoting particular pathways for development, promoting specific actions, strategies, and interventions to enable certain outcomes in socio-technical transitions. Narratives centered around biorefineries take a significant role in the growing bioeconomy discourse, yet they express remarkably different visions for the transition. The paper uses Q methodology to id
When changes happen to big data analytics (BDA) applications in the Cloud at runtime, the affected BDA applications have to be re-deployed to accommodate the changes. Deciding the most suitable deployment is critical and complicated. Although there have been various research studies working on BDA application management, autonomic deployment decision making is still an open research issue. This pa
Sexual dimorphism in eye structure is attributed to sexual selection in animals that employ vision for locating mates. In many male insects, large eyes and eye regions of higher acuity are believed to facilitate the location of females. Here, we compare various features of male and female eyes in three sympatric carpenter bee species, which include two diurnal species (Xylocopa tenuiscapa and X. l
Massive parallel sequencing (MPS) is increasingly used for human identification purposes in forensic DNA laboratories. Forensic DNA samples are by nature heterogeneous and of varying quality, both concerning DNA integrity and matrices, creating a need for assays that can handle low amounts of DNA as well as impurities. Commercial short tandem repeat (STR) analysis kits for capillary electrophoresi
BackgroundIntracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view of recent randomized controlled trials (RCTs) of the management of ICH, the European Stroke Organisation (ESO) has updated its evidence-based guidelines for the management of ICH. MethodA multidisciplinary writing committee
We identified the first set of microsatellites for use in the rock firefinch (Lagonosticta sanguinodorsalis). First, we tested existing passerine microsatellite loci for cross-species amplification success in a small sample of rock firefinches and identified 10 loci that were seemingly polymorphic and easy to score. Secondly, we developed and characterized three microsatellite loci de novo from th
To evaluate whether the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant might be effective for migraine prevention.
