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The purpose of this phase II randomized trial was to evaluate the effect and safety of interferon-2a (IFN) in combination with extended dosing rituximab in patients with symptomatic, advanced indolent lymphoma responding to a standard single course of rituximab. Totally 123 patients were treated with rituximab 375mg/m2 once weekly for 4 weeks leading to 14 complete response (CR; 11%), 56 partial r
Based on high-resolution spectra obtained during gravitational microlensing events we present a detailed elemental abundance analysis of 32 dwarf and subgiant stars in the Galactic bulge. Combined with the sample of 26 stars from the previous papers in this series, we now have 58 microlensed bulge dwarfs and subgiants that have been homogeneously analysed. The main characteristics of the sample an
Background. The procedure of human islet isolation needs further optimization and standardization. Here, we describe techniques to enhance enzymatic digestion and minimize mechanical forces during the digestion process. The isolation protocol has also been modified to meet current GMP (cGMP) standards. Moreover, the impact of donor- and process-related factors was correlated to the use of islets f
As organisations increasingly seek to leverage data for artificial intelligence (AI) analytical use-cases, one of the main challenges towards value realisation is effective use of data governance. Existing research on the topic of data governance focuses on technical and structural aspects of data governance, while this thesis identifies human-centred organisational success factors for data govern
ARKH01 LUNDS UNIVERSITET Institutionen för arkeologi och antikens historia Kurslitteratur ARKH10 Historisk arkeologi: grundkurs, 30 hp Fastställd av institutionsstyrelsen 2011-05-23 Delkurs 1: Historisk arkeologi- introduktion (gemensam med de andra ämnena) Texter delas ut i samband med föreläsningarna. Delkurs 2: Historisk arkeologi – ting, texter och bilder (240 s) Andrén, A. 1997. Mellan ting o
https://www.ark.lu.se/media/utbildning/dokument/kurser/ARKH10/20131/ARKH10_Litteraturlista.pdf - 2026-07-17
In recent years the development and use of crash prediction models for roadway safety analyses have received substantial attention. These models, also known as safety performance functions (SPFs), relate the expected crash frequency of roadway elements (intersections, road segments, on-ramps) to traffic volumes and other geometric and operational characteristics. A commonly practiced approach for
Abstract in UndeterminedCytomegalovirus (CMV) causes severe sequelae in congenitally infected newborns and may cause life-threatening disease in immuno-deficient patients. Recent findings demonstrate the possibility to alleviate the disease by infusing intravenous immunoglobulin G (IgG) preparations, indicating that antibodies are an effective therapeutic option. Modern molecular methodologies, li
The aim of this thesis is to understand how migrants perceive their opportunities to access health care, and how underlying factors result in barriers impacting their access to health care and ability to safeguard their health. It does so by answering the research question: How do Venezuelan migrants in Medellín perceive their access to health care? To fulfil the aim and answer the research questi
Circular economy has recently become a central part of European policy, bridging the environmental and economic policy domains closer than ever in an attempt to fulfil enhanced environmental ambitions. As economic operators seek to adopt innovative solutions, the issue of how established legal frameworks hamper or facilitate them becomes central. This thesis examines this point in relation to on
The global semiconductor industry has benefited from a period of intense geographic specialization, yet faces the growing prospect of a new era of turbulence in international trade relations. Severely disrupted by exogenous shocks in global supply chains, the ability of the industry to cater to ceaseless demand growth is jeopardized by an increasing number of initiatives proposed for most industri
The objective of the present study was to adapt and develop suitable methods to study the occurrence metabolites in the nutrient solution of hydroponically grown tomato. The organic-chemical nature of the nutrient solution from tomato grown in closed hydroponic systems was studied by supported liquid membrane technique (SLM) and analyzed by high-performance liquid chromatography (HPLC). Further, w
One of the Amazon´s most endangered species is the small New World primate, ´pied tamarin´ (Saguinus bicolor). The species only occurs in the vicinity of the Brazilian Amazonas state capital city Manaus, where greatly scattered and fragmented small patches of highly degraded forest remain. The on-going growth of Manaus urban area has created habitat fragments where the pied tamarins now try to per
Allergic rhinitis is a common disease affecting millions of people worldwide. Biocare Copenhagen A/S, a Danish biotechnology company decided to screen a number of probiotic lysates, with the aim to identify suitable strains with potential anti-allergic properties, that could regulate production of cytokines and divert the immune system in a regulatory or tolerant mode. People suffering from aller
The efficacy and safety of an advanced category recombinant antihaemophilic factor produced by a plasma- and albumin-free method (rAHF-PFM) was studied in 111 previously treated subjects with haemophilia A. The study comprised a randomized, double-blinded, crossover pharmacokinetic comparison of rAHF-PFM and RECOMBINATE rAHF (R-FVIII); prophylaxis (three to four times per week with 25-40 IU kg(-1)
Objective: To assess available evidence on the use of end-points ( outcome measures) in clinical trials in systemic lupus erythematosus (SLE), as a part of the development of evidence-based recommendations for points to consider in clinical trials in SLE. Methods: The European League Against Rheumatism (EULAR) Task Force on SLE comprised 19 specialists, a clinical epidemiologist and a research fel
We propose a method for detection of the degree of infection in the paranasal sinuses utilizing a previously published method whereby the viscosity in a sealed container may be measured using an ultrasound Doppler method. As ultrasound propagates in a liquid medium, due to attenuation, the resulting pressure gradient will cause the liquid to move in the propagation direction - the wellknown effect
In preterm infants, low levels of Insulin like growth factor 1 (IGF-I) have been associated with impaired growth and retinopathy of prematurity. Our objective was to study safety and pharmacokinetics of intravenously administered rhIGF-I with its binding protein 3 (rhIGFBP-3) to preterm infants. At 3 days chronological age, an intravenous 3 hours infusion of rhIGF-I/rhIGFBP-3 was administered foll
PURPOSE: Evaluate the effects of radiotherapy after sector resection for ductal carcinoma in situ of the breast (DCIS) in patient groups as defined by age, size of the lesion, focality, completeness of excision and mode of detection. PATIENTS AND METHODS: A total of 1,067 women in Sweden were randomly assigned to either postoperative radiotherapy (RT) or control from 1987 to 1999, and 1,046 were f
The aim of this study was to evaluate the possible learning curve effects on survival during the introduction of vacuum-assisted closure (VAC) therapy in patients with deep sternal wound infection (DSWI). Furthermore, predictors of late mortality were analysed and causes of late death were examined. Fifty-three patients (early Group, n = 26, January 1999 to July 2001 versus late group, n = 27, Aug
Policymakers in publicly funded health-care systems are frequently required to make intricate decisions on which health-care services to include or exclude from the basic health-care package. Although it seems likely that the concept of individual responsibility is an essential feature of such decisions, it is rarely explicitly articulated or evaluated in health policy. This paper presents a tenta
