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A Relative Success? Notes on the circulation and wider reception of Scandinavian Crime

In this paper Scandinavian crime, or Nordic Noir, in its filmic and televisual incarnations, will be considered on its relative merits as a transnationally successful, but regionally based popular cultural expression. The inquiry will be conducted against a backdrop which briefly traces the history and some of the obstacles which historically have limited the transnational circulation of European

Evidence-Based Guidelines for Advancing Continuous Experimentation

Continuous experimentation (CE) is used by many internet-facing companies to improve the value of their products based on user feedback gathered, e.g. through on-line experiments using A/B testing. Frameworks and theories for CE have been derived through academic research from applications in large internet facing companies. To assist practitioners in a broader range of companies, we herein presen

Prior electrocardiograms not useful for machine learning predictions of major adverse cardiac events in emergency department chest pain patients

At the emergency department (ED), it is important to quickly and accurately determine which patients are likely to have a major adverse cardiac event (MACE). Machine learning (ML) models can be used to aid physicians in detecting MACE, and improving the performance of such models is an active area of research. In this study, we sought to determine if ML models can be improved by including a prior

Enhancing individual glomerular filtration rate assessment : can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR

Background: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) wit

Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson’s disease

Cell replacement therapies using human pluripotent stem cell-derived ventral midbrain (VM) dopaminergic (DA) progenitors are currently in clinical trials for treatment of Parkinson’s disease (PD). Recapitulating developmental patterning cues, such as fibroblast growth factor 8 (FGF8), secreted at the midbrain-hindbrain boundary (MHB), is critical for the in vitro production of authentic VM DA prog

Legitimacy

Legitimacy is a relational concept that refers to the perception that the actions undertaken by an actor or an institution are rightful and acceptable. In political terms, an actor enjoys legitimacy if the way it exercises its power is widely considered warranted. In the framework of a major global political process such as the implementation of the 2030 Agenda for Sustainable Development, legitim

Responsibility

Responsibility refers to the obligations that an actor must fulfil. It can be allocated on the basis of different principles. Governments hold the main formal responsibility for the implementation of the Sustainable Development Goals (SDGs). Many other actors can also hold responsibility for accelerating SDG implementation. This is based on principles of closeness, capacity or having caused an out

Economic Impact of Severe Early-Onset Foetal Growth Restriction : A Multicentre Prospective Cohort Study

Objective: Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early-onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage. The resulting preterm births create additional risks independent of FGR. We determined the economic cost associated with severe early-onset FGR. Design: Econom

Documenting Determinants of the Divorce Transition. Micro-Level Evidence from Sweden 1905–1967

Divorce increased dramatically during the twentieth century across the western world. There is surprisingly little research on the determinants of divorce during this transition. We investigate micro-level sociodemographic determinants of divorce in Sweden 1922–1967 using longitudinal data at individual and household level from southern Sweden, focusing on the associations between divorce and wome

A fast approximate method for simulating thermal pile heat exchangers

Ground source heat pump systems, operating in conjunction with vertical ground heat exchangers, will play a key role in decarbonising heating and cooling of buildings. Design of traditional borehole heat exchangers relies on tools which implement routine analytical relationships between heat transferred and the temperature change in the ground and circulating thermal fluid. However, for novel pile

COVID-19 vaccine effectiveness against severe disease from the Omicron BA.1 and BA.2 subvariants: surveillance results from southern Sweden, December 2021 to March 2022

We compared vaccine effectiveness (VE) against severe COVID-19 during calendar periods from December 2021 to March 2022 when Omicron BA.1 and BA.2, respectively, were the dominating virus variants in Scania county, Sweden. We used continuous density case-control sampling matched for sex and age, and with further adjustment for differences in comorbidities and prior infection. VE remained relativel