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Oligonucleotides are short fragments of RNA or DNA that can act as active pharmaceutical ingredients (API) in medicines used to target a wide range of diseases, with further applications continuously emerging. Solid Phase Oligonucleotide Synthesis (SPOS) remains the dominant platform for oligonucleotide production. However, SPOS is characterized by high reagent consumption and a poor sustainabilit
This paper advances scholarship on deliberate destabilisation for sustainability transitions. To understand how deliberate destabilisation plays out in practice, the politics of such processes must be confronted. To this end, we bridge research on the political economy of sustainability transitions with recent theorisations of the deliberate destabilisation of unsustainable socio-technical regimes
VIX, published by the Chicago Board Options Exchange, is a well known implied volatility estimator. In this paper we assess its capability to be used as a sentiment indicator, and to give signals for a short term investment strategy. It will be proved and discussed how VIX-based strategies – also known as “Contrarian” strategies – can be effective as they lead to higher returns than the market. We
In this article, the 2009 European League Against Rheumatism (EULAR) recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have been updated. The 2009 recommendations were on the management of primary small and medium vessel vasculitis. The 2015 update has been developed by an international task force representing EULAR, the European Renal Ass
A Keyless Signing Infrastructure (KSI) provides users with a means to timestamp documents on a per-second basis. The KSI consists of a global infrastructure with several server layers and by using Merkle hash trees, the root hash can be used to verify the integrity and timestamp of a document. Regular publication of root hashes, e.g., once per month, allows a document to be verified without suppor
In December 1998 the FRN - The Swedish Council for Planning and Coordination of Research - decided to fund a new injector and storage ring for the MAX-laboratory. The system will consist of a 50-MeV linac, a 600-MeV booster synchrotron, and a 600-MeV storage ring for VUV undulator beamlines. The system will replace an old 100-MeV racetrack microtron and will inject the two existing storage rings:
A simulation model for embedding the bias of a transistor is presented. The model exploits the simulator equilibrium point calculation to set the bias point of the transistor. The model uses negative feedback to set the bias point according to what the designer desires. When the simulator goes into its main analyses, the negative feedback is broken and embedded bias sources are added. This way it
We derive a fundamental existence theorem for the equation u(t)'(x,t) - div(vertical bar del(x)u vertical bar(p-2)del(x)u) = 0 with continuous initial and boundary data in a space-tithe cylinder.
While traditional forms of urban planning are oriented towards the future, the recent turn towards experimental and challenge-led urban developments is characterized by an overarching presentism. We explore in this article how an experimental approach to urban planning can consider the long-term through setting-up ‘conversations with a future situation.’ In doing so, we draw on a unique experiment
Decision and Value of Information analyses can be highly computational demanding due to the exponential growth of the decision tree in dependency of the state and decision variables. Due to the advancement of computational methods in the last decades, decision problems with moderate complexity maybe solved by a software tool whereas highly complex analyses require tailored approaches, algorithms a
Public procurement accounts for a very large share of most economies worldwide. This conceptual article argues that the key to achieving more innovations when pursuing public procurement is to describe problems to be solved or functions to be fulfilled (functional procurement) instead of describing the products to be bought (product procurement). Contracting authorities need to identify the proble
While Bayesian Optimization (BO) is a very popular method for optimizing expensive black-box functions, it fails to leverage the experience of domain experts. This causes BO to waste function evaluations on bad design choices (e.g., machine learning hyperparameters) that the expert already knows to work poorly. To address this issue, we introduce Bayesian Optimization with a Prior for the Optimum
The conflict between Armenia and Azerbaijan over Nagorno-Karabakh has put the Islamic regime of Iran in a difficult position. While the government is trying to be neutral, other regime elements have openly taken sides in the conflict.
Pythia8 is the only general purpose event generator able to produce complete fully exclusive hadronic final states in collisions involving heavy ions. The model that allows this is called Angantyr and will be discussed in this contribution. The contribution also discusses models based on interactions between strings in an extention of the Lund model that are able to describe some collective effect
