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The ability to successfully replace lost nigral dopaminergic neurons in Parkinson's disease (PD) has been clearly shown with fetal ventral mesencephalic transplants, albeit inconsistently. The need to trial this approach with stem-cell-derived neurons is approaching, but it should only commence when all the key issues have been adequately resolved.

Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remission of nephrotic syndrome in patients with diverse glomerulopathies, even those resistant to steroids. The underlying mechanism remains elusive, but the role of melanocortin 1 receptor (MC1R) h

Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). During pregastrulation development, stem cells convert and epithelial tissu

This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich-club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3-months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolle

Detection of ANCA has become an important tool for the diagnosis and monitoring of disease activity in Wegener's granulomatosis (WG). Unfortunately, a group of sera positive by the standard method for ANCA detection, indirect immunofluorescence (IIF), are negative when more specific tests with purified proteins are used. In order to examine this discrepancy we examined groups of sera selected for

In Mycena sectio Calodontes with otherwise amyloid spores, the inamyloid spores of Mycena pearsoniana Dennis ex Singer were a distinguishing feature for this species and its subsection Violacella. Although the original concept of this species was European, Singer chose to typify it with material collected in Mexico. The name has since been applied to all European collections with inamyloid spores

December 2nd 2016 it was established that Oatly had a new co-owner, China Resources, a partnership that went against not only their own core values but also the values of their oat followers. However, it was not until 2019 the media storm drew in. Oatly owned the spotlight and the debates continued whether Oatly could be trusted or if boycott was the best decision. Oatly however, answered the crit

Internet services can aid steps towards sustainability, but can also be a means of exploitation and power-ownership. Data centres are an intrinsic part of this system, but reporting regulations do not require full disclosure on them. This paper takes the position that incomplete or misleading reporting is a form of delay discourse. Using the case study of Spotify, a structured literature review wa

The incidence of treatment-related neuroendocrine prostate cancer (t-NEPC) is rising as more potent drugs targeting the androgen signaling axis are clinically implemented. Neuroendocrine transdifferentiation (NEtD), an putative initial step in t-NEPC development, is induced by androgen-deprivation therapy (ADT) or anti-androgens, and by activation of the β2-adrenergic receptor (ADRB2) in prostate

Who benefits from the ignorance of others? We address this question from the point of view of a policy maker who can induce some ignorance into a system of agents competing for resources. Evolutionary game theory shows that when unconditional cooperators or ignorant agents compete with defectors in two-strategy settings, unconditional cooperators get exploited and are rendered extinct. In contrast

Increasingly, greening in cities across the Global North is enmeshed in strategies for attracting capital investment, raising the question: for whom is the future green city? Through exploring the relationship between cities’ green boosterist rhetoric, affordability and social equity considerations within greening programmes, this paper examines the extent to which, and why, the degree of green br

Background: Collider bias is often considered a potential explanation when the association between obesity and disease diagnosis differs from that with disease outcome, as seen in the “obesity paradox.” For prostate cancer (PCa), in particular localized PCa, an “inverse” obesity paradox has been observed, where body mass index (BMI) is negatively associated with diagnosis (hazard ratio [HR] ~0.9 p

This study investigates the integration of Large Language Models with the TRIZ to improve problem solving and innovation in industrial product development. By combining the structured problem-solving framework of TRIZ with LLMs to process large amounts of data and generate ideas, this hybrid approach seeks to overcome the limitations of traditional TRIZ and optimize solution generation. In a case

https://www.ses.lu.se/att-forebygga-verksamhetsavfall-och-upplasningar/about-project - 2026-07-19

The purpose of this paper is to propose a new approach for categorizing the body of knowledge captured in the existing literature, past and present in such a way that contributions to the use side of systems development are made explicit. The new twist of this approach is that it seeks to bridge the most prevalent divides currently fragmenting the IS literature by offering an integrative classific