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Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.
For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem,we introduce persistent homology as a rigorous framework that can be used to both define a
During the Middle Ages the concepts of `them and us' became concrete in the shape of fiercely defended frontiers, some of which were physical, geographic and political, while others were more ideological. This volume, the proceedings of an international symposium held at Lund University in 2000, presents twenty-four papers which examine the archaeological evidence for frontiers across Europe. Divi
In a globalized world subjected to ongoing rapid technological development and increasingly evocative entertainment, advertisers are turning their attention to methods of provocation in an effort to induce actionable behavior from the consumer. Struggling to fight their way through the challenging environment of todays saturated market and appeal to the increasingly desensitized consumer, advertis
This thesis will inquire into the contemporary neo-Yugoslavian culture in Sweden and cultural intimacy as a base to recreate the bonds from the past. Moreover, mutual impacts between the two substantially different societies, the society of free individuals of the Swedes and neo- Yugoslav collectiveness, duh Yuge, are the result of a multifaceted process with intriguing outcomes. Zlatan Ibrahimovi
Ligand exchange on square-planar Pt(1,4-dithiane)2(2+), Pd(1,4-dithiane)2(2+), and Pt(Me2S)4(2+) has been studied as a function of temperature and pressure by H-1 NMR line-broadening, isotopic labeling, and magnetization transfer experiments with deuteriated nitromethane as solvent. Second-order rate constants and activation parameters are as follows: for 1,4-dithiane exchange on Pt(1,4-dithiane)2Ligand exchange on square-planar Pt(1,4-dithiane)2(2+), Pd(1,4-dithiane)2(2+), and Pt(Me2S)4(2+) has been studied as a function of temperature and pressure by H-1 NMR line-broadening, isotopic labeling, and magnetization transfer experiments with deuteriated nitromethane as solvent. Second-order rate constants and activation parameters are as follows: for 1,4-dithiane exchange on Pt(1,4-dithiane)2
Because incubation by birds is energetically costly, parents frequently trade off investment in incubation against self-maintenance. This can be manifested by a reduction in incubation temperature, which comes at high somatic costs for nestlings. The extent to which these costs constrain fitness is poorly understood. We incubated wild blue tit clutches at three biologically relevant temperatures a
The circular economy is becoming a globalised phenomenon, but the regional emergence of circular business models differs significantly. By adopting a circular business institutionalisation perspective which bridges theory on institutional work and “ecologies of business models” we study the emergence of circular business models in Japan, a region with recent circular policy and business commitment
This research monograph explores new frontiers in Markov chains. Although time-homogeneous Markov chains are well understood, this is not at all the case with time-inhomogeneous ones. The book, after a review on the classical theory of homogeneous chains, including the electrical network approach, introduces several new models which involve inhomogeneous chains as well as related new types of rand
As a major buyer of steel, the construction sector is uniquely positioned to advance the decarbonization of global steel through increasing the demand for green steel. To unlock this potential, deepened international collaborations on green public procurement, climate policies, and trade are needed.
In 1735, professor Kilian Stobaeus donated his collections to Lund University laying the foundation for the university’s first museum. The ”Museum Stobaeanum” contained over 3000 natural history, historical and ethnographic objects typical of the cabinets of curiosity. This richly illustrated book is the first comprehensive history of these collections.Eighteen chapters, written by an interdiscip
Nyhetsbrev från Akademikerföreningen Sveriges Ingenjörer vid Siemens Energy AB Kontakt: asi.se@siemens-energy.com Redaktörer: SvE, CH, SJ Nr: 02/24 2024-02-12 Lönerörelsen drar i gång Vi går strax in på det andra och sista året av nu gällande kollektivavtal. I och med det så har även lönerörelsen dragit igång. Därför vill vi informera om tidplan och några hållpunkter som är viktiga för er att håll
