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BACKGROUND: α-synuclein (α-syn) aggregation contributes to the progression of multiple neurodegenerative diseases. We recently found that the isoform b of the co-chaperone DNAJB6 is a strong suppressor of a-syn aggregation in vivo and in vitro. However, nothing is known about the role of the endogenous isoform b of DNAJB6 (DNAJB6b) in health and disease, due to lack of specific antibodies.OBJECTIV

We prove the first hardness results against efficient proof search by quantum algorithms. We show that under Learning with Errors (LWE), the standard lattice-based cryptographic assumption, no quantum algorithm can weakly automate TC0-Frege. This extends the line of results of Krajíček and Pudlák (Information and Computation, 1998), Bonet, Pitassi, and Raz (FOCS, 1997), and Bonet, Domingo, Gavaldà

It is concluded that Melandrium glutinosum Rouy belongs in Sectíott jilisanthe oí Silene. It is certainly a distinct species and ¡ts correct ñame is S. marigii.A description is given. The species is believed to be endemic to the Iberian península and occurs among granite bonlders in the mountains of central Spain and northwest Portugal.Resumen. Se concluye que Melandrium glutinosum pertenece a la

The editors of Interfaces: A Journal of Medieval European Literatures explain the scope and purpose of the new journal by mapping out the significance and possible meanings of the three key terms of the subtitle: ‘literature,’ ‘medieval,’ ‘Europe.’ The specific theme of Issue 1 is introduced: ‘Histories of Medieval European Literatures: New Patterns of Representation and Explanation.’ With respect

The personal is still political as heterosexual romantic relationships are permeated by gender power dynamics. Previous research has shown that men tend to exploit women’s love, appropriate their care, and not reciprocate. This study looks at the impact of feminist values on these established patterns in Switzerland, a country known for being one of the last in western Europe to give women the rig

Strategic thinking is a complex field that consists of more than the concept of strategy. Strategic thinking is important to business success, to maintain a competitive advantage, to strategic planning, and management decision-making. However, this is not an exhaustive list of reasons why strategic thinking is relevant. Research in the science and professional fields have failed to agree on one fi

Inflation targets are set by central banks worldwide to achieve stable and sustainable growth and the possibility of institutional quality affecting the inflationary effect on growth makes it essential to study the inflation-institution-growth relationship. This paper considers whether or not the relationship between inflation and growth is nonlinear in the shape of convexity and if it differs for

Purpose: The study aims to investigate the knowledge sharing processes in a knowledge-intensive firm and to explore how organizational culture influences knowledge sharing. Methodology: The present study is qualitative, and the material is approached through interpretative reading. The richness of the results is further enhanced by critically analyzing the informants’ taken for granted understandi

Nearly all BITs include the MFN standard. The conventional idea appears to have held that the MFN standard only entitles the beneficiary of an MFN provision to invoke more favorable substantive provisions. However, this conception was altered in 2000 when an ICSID tribunal rendered an award in which it held that the scope of an MFN clause may include dispute settlement and questions of jurisdictio