Filetype
Objectives: We recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality. Method
PURPOSE: The goal of this study was to identify proteins down-regulated during bladder cancer progression.EXPERIMENTAL DESIGN: By using comparative proteome analysis and measurement of mRNA, we found a significant down-regulation of S100C, a member of the S100 family of proteins, in T24 (grade 3) as compared with RT4 (grade 1) bladder cancer cell lines. Moreover, quantification of the mRNA level r
Prosthetic loosening has been debated for decades, both in terms of the timing and nature of the triggering events. Multiple radiostereometric studies of hip prostheses have now shown that early migration poses a risk of future clinical failure, but is this enough to explain late clinical loosening? To answer this question, the progression of loosening from initiation to radiographic detection is
Today, the Internet of Things (IoT) is mainly associated with vertically integrated systems that often are closed and fragmented in their applicability. To build a better IoT ecosystem, the open IoT platform has become a popular term in the recent years. However, this term is usually used in an intuitive way without clarifying the openness aspects of the platforms. The goal of this paper is to cha
Objective: Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods: Through nationwide registries, we identified all individuals aged 18-50
Quantitative structure-activity relationship (QSAR) parameters are good indicators for the reactivity of direct-acting antiviral drugs. Since molecular structure is related to molecular function, careful selection of molecular substitutions will result in more drugs that are potent. In this work, QSAR parameters are selected in order to compare the four drugs used as nucleotide inhibitors (NIs) fo
Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic diseases. It has long been thought that murine bone marrow-derived T cells do not mediate severe GVHD because of their quantity and/or phenotype. During the course of experiments testing the impact of housing temperatures on GVHD, we discovered
Background: Immune complexes (ICs) are detectable in a variety of inflammatory diseases, including systemic lupus erythematosus (SLE), reflecting autoantibody binding to antigens. Though ICs are the main contributors to disease pathogenesis through FcγR-mediated inflammation and organ damage, IC levels are not part of the clinical assessment of SLE. The aim of this study was to explore the clinica
We describe the molecular characterization of the Drosophila gene tenm, a large transcription unit spanning > 110 kb of DNA. tenm encodes a large extracellular protein of 2515 amino acids related to the extracellular matrix molecule tenascin. The Tenm protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. tenm mutants show a phenotype
Traditionally, atherosclerosis has been evaluated macroscopically from the presence of fatty streaks (FS), fibrous plaques (FBP), and complicated lesions (CL). In this preliminary study, employing aortas from autopsied middle-aged or older persons we investigated the fatty raised lesion (FRL) to elucidate its significance and histological features. The FRL is determined macroscopically from its di
If we ever decide to start geoengineering another world, and maybe even terraform a world that is not presently habitable for humans, it is also highly probable that it will become less habitable for any indigenous life. Making sure, or at least trying to determine the probability that a potentially habitable world is in fact uninhabited will thus be an important step before we start any geo-engin
This thesis examines the integration of Somalis in Norway, pointing out how Somalis are allegedly worse integrated than other groups of immigrants in Norway. The thesis examines why this may be and what factors affect Somali integration in Norway. The study is based on a content analysis of government documents regarding integration strategies in Norway and five podcast episodes featuring people o
The third round of NDCs were due to be released in the lead up to COP30 in November 2025, with parties to the Paris Agreement set to detail commitments to more ambitious emissions reductions. The content of past NDCs have differed greatly depending on which country is submitting the document, especially in how well gender is integrated across actions for NDC implementation. Previous studies show t
