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To date, not that much. Improvements are possible, but some system-theoretically grounded re-design is necessary. We discuss the matter based on our experience, and as a consequence, we come to distilling some design clues and research directions.
In order to determine the mode of beat-to-beat decay of contractility from very high levels, we studied the beat-by-beat decay of cardiac contractility following potentiation. Such decay curves are normally analysed using a mono-exponential decay function, which assumes that a fixed fraction of activator calcium ions is recirculated from one beat to the next. We postulated that there might be devi
Magnesium chelatase is the first unique enzyme of the chlorophyll biosynthetic pathway. It is composed of three gene products of which the largest is 150 kD. This protein was recently identified as an abscisic acid receptor in Arabidopsis (Arabidopsis thaliana). We have evaluated whether the barley (Hordeum vulgare) magnesium chelatase large subunit, XanF, could be a receptor for the phytohormone.
Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmo Diet and Cancer Cohort (MDCC) and
Today, a climate crisis is immanent. In this thesis I have conducted nine semi-structured interviews with Swedish climate activists. I here answer four research questions: 1) how they construct the problem of climate change; 2) how they present the non-activists and their motivations; 3) how they present themselves and their own role; and 4) how strategies and reactions can be understood from the
Digitalization has in recent years transformed the music industry and how people consume music. Simultaneously, the social media app TikTok has emerged as a major player in marketing, using its unique algorithmic structure and user-generated content to become a powerful marketing tool for musicians and record labels alike. Therefore, this paper investigates the effect of TikTok on music consumptio
Nature-Based Solutions (NBS) is an emerging concept which has the potential to address several sustainability challenges. In this multiple case study research on three NBS projects in Gothenburg (Sweden) the projects objectives and evaluated impacts are studied to provide insights into how NBS interventions are implemented in urban contexts. In addition, barriers and drivers for up-scaling are ide
This thesis investigates the causal effects of the Peruvian conditional cash transfer (CCT) program, Juntos, on women’s empowerment defined along the psychological and familial dimensions. Usually, the main goal of CCTs is to reduce poverty. Women are key actors in the fulfillment of conditions and recipients of the transfer, and can thus also be affected by the program in terms of empowerment. Th
The hotel industry's growth raises concerns about its societal and environmental impacts, prompting hotels to engage in various practices for environmental preservation, fair HR management, and community well-being among others. Previously reporting on such practices in their sustainability reports, hotel chains now feel a stronger obligation to adhere to Environmental, Social, and Governance
China is experiencing a rapid economic transformation, which witnesses a vast number of labourers moving out of agricultural sectors. In such a transformation, the effect of spatial income variance on labour’s off-farm work decision is still unclear. Based on the cross-sectional data from the national survey conducted in 2012, this study finds the effect on two kinds of off-farm employment, wage e
Following a macroeconomic stabilization and consistent economic growth during the 2000s, Brazil experienced a continuous decrease on poverty incidence for the first time in its contemporary history. While the literature emphasizes the importance of economic growth alongside social development to fight poverty, the Brazilian experience also displays strong government action through expanding social
Women have been regarded as a disadvantaged group in Nepal (Aoki & Pradhan, 2013), because of the limited opportunities in these areas, women residing in rural parts of Nepal such as, Kudari VDC in Jumla, are particularly vulnerable. The women in Jumla normally are involved in daily household jobs like cooking, cleaning, washing, feeding the cattle etc. The Maoist insurgency (about a 10 years
OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive pati
Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 (Gpc-1) is generated in endosomes by an endogenously or ascorbate induced SNO-catalyzed reaction. Processing of the amyloid precursor protein (APP) and APP-like protein 2 (APLP2) by β- and γ-secretases into amyloid beta (Aβ) and Aβ-like peptides also takes place in these compartments. Moreover, anMan-co
We report electron transfer between the catalytic molybdenum cofactor (Moco) domain of human sulfite oxidase (hSO) and electrodes through a poly(vinylpyridine)-bound [osmium(N,N'-methyl-2,2'-biimidazole)(3)](2+/3+) complex as the electron-transfer mediator. The biocatalyst was immobilized in this low-potential redox polymer on a carbon electrode. Upon the addition of sulfite to the immobilized sep
INTRODUCTION: Structural right atrial abnormalities have been described in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, little is known about electrocardiographic signs of atrial involvement in ARVC because no systematic studies have been conducted. METHODS: P-wave-triggered signal-averaged orthogonal electrocardiogram from 40 ARVC patients (46 ± 15 years, 16 fema
Orthogonal P-wave morphology has previously been described in different populations, but its relation to atrial size has not been studied in detail. In this study, we investigated whether atrial size affects P-wave morphology in athletes, who are known to have different degrees of atrial enlargement.
