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This study is an effort to find a connection between the high number of people on sick leave, the occupational health situation at the workplace, and stronger market competition and globalisation forces. The basis for the study is statistics, mainly on injuries and diseases, interviews with people in different positions with either long experience within the safety and health situation or otherwi
Patients with pancreatic ductal adenocarcinoma (PDAC) commonly develop symptoms and signs in the 1-2 years before diagnosis that can result in changes to medications. We investigate recent medication changes and PDAC diagnosis in Nurses' Health Study (NHS; females) and Health Professionals Follow-up Study (HPFS; males), including up to 148,973 U.S. participants followed for 2,994,057 person-years
We have studied excitation energy transfer in the photosynthetic antenna systems LH1 and LH2 of purple bacteria. Femtosecond pump-probe experiments were combined with computer simulations using the recently established structure of these systems to assess the nature of electronic excitation. We have measured the transient absorption kinetics and spectra of the LH1 and LH2 complexes in the tem
DEXD/H-box RNA helicases couple ATP hydrolysis to RNA remodeling by an unknown mechanism. We used x-ray crystallography and biochemical analysis of the human DEXD/H-box protein DDX19 to investigate its regulatory mechanism. The crystal structures of DDX19, in its RNA-bound prehydrolysis and free posthydrolysis state, reveal an alpha-helix that inserts between the conserved domains of the free prot
More than 12,000 South Korean doctors have gone on strike in a months-long protest against medical reforms. It may be the wrong position to take, but the government has much to account for too, say Erik Mobrand from Seoul National University and Hyejin Kim from National University of Singapore.
Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer's disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. Whether altered plasma liver-derived apoE or specifically an APOEε4 liver phenoty
Neuroblastoma is a childhood developmental cancer; however, its embryonic origins remain poorly understood. Moreover, in-depth studies of early tumor-driving events are limited because of the lack of appropriate models. Herein, we analyzed RNA sequencing data obtained from human neuroblastoma samples and found that loss of expression of trunk neural crest–enriched gene MOXD1 associates with advanc
Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neur
Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated wit
Multiconfigurational pair-density functional theory (MC-PDFT) is a promising way to describe both strong and dynamic correlations in an inexpensive way. The functionals in MC-PDFT are often “translated” from standard spin density functionals. However, these translated functionals can in principle lead to “translated spin densities” with a nonzero imaginary component. Current developments so far ne
In recent decades, with the advancement of technologies facilitating reproduction, parents have been able to make decisions regarding their childrens’ reproductive potential: to preserve their fertility when threatened by genetic conditions or medical treatment; to use their gametes or embryos to make grandchildren; or even to collect their gametes posthumously and then use them to make grandchild
Variation in the structure and size of the eye in relation to light environments is well-documented across animal taxa. However, the long-term effects of ultraviolet radiation (UVR) on eye size across generations remain understudied, despite natural fluctuations in UVR being common in aquatic habitats. Here, we used Daphnia magna to test whether an evolutionary history of UVR threat modifies plast
Cupriavidus is a bacterial genus related to Burkholderia, with members that can be negative or positive for us. Some species can give people serious, and even deadly diseases. Among the species positive for us is one that can be used for replacing plastic production from fossil oil by a more sustainable method.
The goal of this thesis is to answer the question what is the probability that the U.S. economy will experience a recession and a concomitant financial crisis in the near future. The question is answered through the use of a probit model, in which five explanatory variables, derived from previous research, are processed. The variables are Current Account to GDP, NYSE Composite Index, Domestic Cred
