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Popular Abstract in Swedish Svår alfa-1antitrypsinbrist (AAT-brist), s.k. PiZZ, är ett ärftligt tillstånd som har en hög förekomst i Sverige, cirka 1/1600. Bristen innebär ökad risk för utveckling av kroniskt obstruktiv lungsjukdom (KOL), speciellt hos rökare. Leversjukdom är också relativt vanlig och kan förekomma såväl i barndomen som i hög ålder. Levercirros (skrumplever) och levercancer är öveSevere alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. The aims of the studies in this thesis which bases on AATD registry are to

Objectives. Cirrhosis is a well-known risk factor for hepatocellular cancer, but the true risk in autoimmune hepatitis (AIH) is scarcely studied. Other cancers may arise after prolonged use of immune-modulating drugs. The aim of this study was to investigate the cancer risk in a large cohort of AIH patients. Material and methods. Six hundred and thirty-four Swedish patients in a well-defined cohor

Objectives. To study the correlation between Sunnybrook and House-Brackmann facial grading systems at different time points during the course of peripheral facial palsy. Study Design. Prospective multicenter trial. Setting. Seventeen otorhinolaryngological centers. Subjects and Methods. Data are part of the Scandinavian Bell's palsy study. The facial function of 1920 patients with peripheral facia

Beta-microseminoprotein (MSP) is one of the most abundant proteins secreted by the prostate gland. Because MSP is also synthesized in nonreproductive organs, the establishment of a solid relationship between the levels of MSP in serum and semen is crucial for future studies connecting MSP with aging or diseases of the prostate gland. We developed a specific, competitive, europium-based immunoassay

In neuroblastoma (NB) patients, minimal residual disease (MRD) can be detected by real-time quantitative PCR (qPCR) using NB-specific target genes, such as PHOX2B and TH. However, it is unknown whether the mRNA levels of these targets vary either during treatment or at relapse. If marker genes are not stably expressed, estimation of MRD levels in bone marrow (BM) or peripheral blood will be hamper

Measurements of cross sections of inelastic and diffractive processes in proton-proton collisions at LHC energies were carried out with the ALICE detector. The fractions of diffractive processes in inelastic collisions were determined from a study of gaps in charged particle pseudorapidity distributions: for single diffraction (diffractive mass M-X < 200 GeV/c(2)) sigma(SD)/sigma(INEL) = 0.21 +/-

As the industrial, commercial, and domestic prevalence of Internet of Things networks grows, so does the search for viable solutions to decrease their energy consumption. One common solution is using a low-power proxy that can control the power state of the devices within the network. To evaluate such solutions, either implementations can be made and measured for energy consumption, or energy mode

The study aimed at (a) investigated the ability of potential lactic acid bacteria (LAB) to ferment quinoa milk, and (b) formulating a method for producing fermented quinoa milk. To meet the objectives, Lactobacillus pentosus and Pediococcus pentosaceus two native bacterial strains were tested. Quinoa milk elaboration was optimized at laboratory scale by selecting an appropriate quinoa/water propor

To compete on the global market many companies need to undergo fundamental organizational changes. However, many companies fail to make successful transformations. To identify the factors that contribute to a successful transformation, some researchers have focused on a micro perspective and investigated employees’ characteristics and attitudes (e.g., organizational commitment, readiness for chang

Saccharomyces cerevisiae has emerged as a versatile platform for whole-cell biocatalysis, owing to its intrinsic regeneration of cofactors and amenability to genetic engineering. However, efficient reductive amination of aromatic carbonyls remains challenging due to competing redox pathways and product inhibition by pyruvate. Building on the redox-rewired TMB4133 strain (∆gpd1,2) that accumulates

This master’s thesis maps and compares local literary networks within UNESCO’s Cities of Literature, with the aim of understanding how such networks are structured, what their functions are and how they are controlled and developed. Drawing on concepts from social network analysis and Bourdieu’s theories of social fields, capital and habitus, the study combines quantitative and qualitative methods

Massive MIMO has attracted many researchers’ attention as it is a promising technology for future 5G communication systems. To characterize the propagation channels of the massive MIMO and to evaluate system performance, it is important to develop an accurate channel model for it. In this thesis, two correlative models, i.e., the Kronecker model and the Weichselberger model, and a cluster-based m

Abstract Metal oxide semiconductor (MOS) capacitor was fabricated on the InGaAs substrate with Al2O3/HfO2 gate oxide. InGaAs is one of the promising candidates for advanced applications which require the lower power supply and high frequency. The high-k films (Al2O3/HfO2) were formed by atomic layer deposition (ALD) as an alternative to silicon dioxide (SiO2) to proceed the scaling of oxide to low

The aim of our study was to examine the relationship between creativity and wellbeing. The material for our study has been gathered through a questionnaire with self-assessment at one of Scandinavia's largest companies in the hotel industry. The questionnaire consisted of The organisational questionnaire (GEFA) and The measurement of wellbeing. In the study 90 questionnaires was distributed in

In recent years, as Internet of Things (IoT) and machine learning technologies have advanced, there has been increasing interest in the study of energy-efficient and flexible architectures for embedded systems. To bridge the performance gap between microprocessors and memory systems, Near-Data Processing (NDP) was introduced. Although some works have implemented NDP, few of them utilize the microp