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A new aromatic pair, 2-hydroxy-6-methoxybenzamide/1-methylpyrrole at the terminal position of hairpin polyamides has been designed for distinguishing T·A from A·T base pairs and both from G·C/C·G in the minor groove of DNA. Four eight-ring hairpin polyamides with benzamide (Bz), 2-hydroxybenzamide (Hb-1), 2-hydroxy-6-methylbenzamide (Hb-2), and 2-hydroxy-6-methoxybenzamide (Hb-3) at the N-terminal
The aim of this study is to describe in what way the students' learning outcomes and theoretical assumptions are used by teachers to enhance the design of lessons with a focus on development of sustainable learning over time. Seven teachers and 71 students in an upper secondary school participated, along with one researcher. Three lessons were designed and implemented in three different student gr
We report the discovery of a hot (Teq ≈ 1055 K) planet in the small-planet radius valley that transits the Sun-like star TOI-733. It was discovered as part of the KESPRINT follow-up program of TESS planets carried out with the HARPS spectrograph. TESS photometry from sectors 9 and 36 yields an orbital period of {equation presented} days and a radius of {equation presented}. Multi-dimensional Gauss
Soil functions can be classified as supporting (nutrient cycling) and provisioning (crop production) ecosystem services (ES). These services consist of multiple and dynamic functions and are typically assessed using indicators, e.g. microbial biomass as an indicator of supporting services. Agricultural intensification negatively affects indicators of soil functions and is therefore considered to d
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history
Introduction Bladder exstrophy is a rare congenital malformation of the bladder and is believed to be a complex disorder with genetic and environmental background. We describe a young adult female with an isolated bladder exstrophy and with an X chromosome aberration. Patients and Methods Karyotyping identified an X chromosome rearrangement that was further characterized with array comparative gen
Soil biodiversity through its delivery of ecosystem functions and attendant supporting ecosystem services-benefits soil organisms generate for farmers-underpins agricultural production. Yet lack of practical methods to value the long-term effects of current farming practices results, inevitably, in short-sighted management decisions. We present a method for valuing changes in supporting soil ecosy
A search for the b (b) over bar decay of the Standard Model Higgs boson is performed with the ATLAS experiment using the full dataset recorded at the LHC in Run 1. The integrated luminosities used are 4.7 and 20.3 fb(-1) from pp collisions at root s = 7 and 8 TeV, respectively. The processes considered are associated (WIZ)H production, where W -> e nu/mu nu, Z -> ee/mu mu, and Z -> nu nu. The obse
Nanoplastics (NPs) originated from plastic residues can interact with soil microorganisms with potential negative effects to their functions. Therefore, I aimed to investigate soil microbial population dynamics when exposed to different NP polymers and concentrations. I used microfluidics technology to produce a soil micromodel – a soil chip - comprising basic pore geometries where microorganisms
This report takes stock of the current climate finance landscape in India, along with the estimated financing requirements, enabling conditions and macro policy instruments to achieve national 1.5oC and 2oC goals. Climate change will negatively affect India’s economy leading to annual Gross Domestic Product (GDP) loss of 3 per cent to 10 per cent by 2100 (Kompas et al., 2018; RBI, 2023). In a busi
This paper explores how three cognitive and perceptual cues, vocal iconicity, resemblance-based mappings between form and meaning, and segment position and lexical stress, interact to affect word formation and language processing. The study combines an analysis of the word-internal positions that iconic segments occur in based on data from 245 language families with an experimental study in which
Purpose of Review: Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical studies, a significant number of clinical trials using MSC-based treatment for COVID-19-associated ARDS were initiated during the global pandemic. Here, we aimed to discuss differences and similarities in clinical trials using MSC-based treatments for classi
We present the spectroscopic confirmation and precise mass measurement of the warm giant planet TOI-199 b. This planet was first identified in TESS photometry and confirmed using ground-based photometry from ASTEP in Antarctica including a full 6.5 hr long transit, PEST, Hazelwood, and LCO; space photometry from NEOSSat; and radial velocities (RVs) from FEROS, HARPS, CORALIE, and CHIRON. Orbiting
: Based on the recent progress on research and development on automated vehicles, mass production of partially autonomous driving vehicles is expected to be available in the 2020s. According to the SAE standard level 3, a takeover situation may occur where the vehicle driving party changes if autonomous driving is released for unavoidable reasons resulting from vehicle or system limitations. In th
Digital innovation offers promising avenues for accessible, engaging, and user-friendly training solutions, crucial for promoting safety among manufacturing workers. However, optimizing these solutions demands a profound understanding of workers’ needs and preferences in interacting with these digital systems. The ongoing “DigiSafeMan” project aims to develop a prototype of a digital training tool
Atmospheric measurements show that emissions of hydrofluorocarbons (HFCs) and hydrochlorofluorocarbons are now the primary drivers of the positive growth in synthetic greenhouse gas (SGHG) radiative forcing. We infer recent SGHG emissions and examine the impact of future emissions scenarios, with a particular focus on proposals to reduce HFC use under the Montreal Protocol. If these proposals are
Background: This project plan proposes a new learning activity and assessment model of medical students' empathy and communication skills. An empathic ability and communication skills are crucial in a student future role as a physician. Empathy and communication skills are also Entrustable Professional Activities in most undergraduate medical educational programs1.Method: The students are first in
