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Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of PSA screening, PrCa incidence, positive predictive value of PSA, biopsy, and tumour characteristics after 3 yr of screening, by BR
This paper develops a model based on the concept of Positive Mathematical Programming (PMP) that is useful for ex-ante analyses of how policy measures affect commercial fisheries. PMP models are frequently used in agriculture, but rarely for analyzing fisheries. Fisheries often face a large set of constraints such as effort regulations and catch quotas of which some might be binding and others not
Standing wave ambient pressure photoemission spectroscopy (SWAPPS) is a promising method to investigate chemical and potential gradients across solid-vapor and solid-liquid interfaces under close-to-realistic environmental conditions, far away from high vacuum. Until now, these investigations have been performed only near room temperature, but for a wide range of interfacial processes, chief among
The Soil and Water Assessment Tool (SWAT) model has been widely applied for simulating the water cycle and quantifying the influence of climate change and anthropogenic activities on hydrological processes. A major uncertainty of SWAT stems from the poor representation of vegetation dynamics due to the use of a simplistic vegetation growth and development module. Using long-term remote sensing-bas
Mechanical behavior of meniscus can be modeled using constitutive material models of varying complexity, such as isotropic elastic or fibril reinforced poroelastic (FRPE). However, the FRPE material is complex to implement, computationally demanding in 3D geometries, and simulation is time-consuming. Hence, we aimed to quantify the most suitable and efficient constitutive model of meniscus for sim
Within the Action Plan for Humanitarian Adaptation to Climate Change initiated by the German Federal Foreign Office a new and innovative framework to humanitarian action is developed, the forecast-based financing mechanism. This scientifically based funding system shall enable practitioners and donors to react faster to oncoming natural extreme events, while supporting local communities in adaptin
With the open and big data movement in full swing, data sharing becomes more ubiquitous and more often crosses sectoral boundaries. The promise of data to help address societal issues and foster innovation requires public organizations to work together with businesses and researchers. Data collaboratives whereby actors collaborate to share and use data for public good gain increasing interest. Mos
The assessment of flood vulnerability is a complex task that involves numerous uncertainties. Within this context, sensitivity analyses are crucial to better understand the variability of vulnerability index outcomes according to different input parameters. The present study sheds light on the importance of assessing the sensitivity of different criteria weights to construct flood vulnerability in
The ratio of leaf carotenoid to chlorophyll (Car/Chl) is an indicator of vegetation photosynthesis, development and responses to stress. However, the correlation between Car and Chl, and their overlapping absorption in the visible spectral domain pose a challenge for optical remote sensing of their ratio. This study aims to investigate combinations of vegetation indices (VIs) to minimize the influ
Combined density functional theory (DFT) and X-ray standing wave (XSW) studies have previously provided evidence for the preferential adoption of an inverted conformation of 2H-TPP on Cu(111) in contrast to the saddle conformation usually favored by porphyrin molecules adsorbed on metals. We experimentally demonstrate, via X-ray photoelectron spectroscopy (XPS) analysis, that the binding energies
Background/Objectives: Antibiotic resistance presents an urgent public health threat. By developing a streamlined and effective method for studying bacteriophage induction, this research marks a step further in understanding how antibiotic-resistant genes might spread across different environments. This knowledge is essential for creating strategies to reduce the spread of antimicrobial resistan
Density functional theory (DFT) thermochemistry of 3d transition-metal complexes is well-known to be sensitive to the amount of exact Hartree-Fock exchange incorporated into the exchange-correlation functional. For example, relative energies of different protonation states of iron-sulfur complexes may vary by hundreds of kJ/mol among different DFT methods. In the present study, we examine the rela
False lumen management of chronic aortic dissections has evolved during the past decade. Thoracic endovascular aortic repair (TEVAR) continues to be the mainstay of endovascular dissection treatment and relies on the adequate sealing of the proximal entry tear. However, TEVAR alone often fails to achieve aortic remodeling due to persistent distal retrograde perfusion of the false lumen with contin
Automated sorption balances are widely used for characterizing the interaction of water vapor with hygroscopic materials. This paper is part of an interlaboratory study investigating the stability and performance of automated sorption balances. A previous paper in this study investigated the mass, temperature, and relative humidity (RH) stability of automated sorption balances by looking at the ma
This report reviews the published results of searches for possible additional scalar particles and exotic decays of the Higgs boson performed by the ATLAS Collaboration using up to 140 fb−1 of 13 TeV proton–proton collision data collected during Run 2 of the Large Hadron Collider. Key results are examined, and observed excesses, while never statistically compelling, are noted. Constraints are plac
