Filetype
Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient (-/-) and atg7-/-macrophages, we provide evidence that loss of ATG5 but not of ATG7 resulted in LC3-II depletion. Accumulation of LC3-II in elicited atg7-
Deciphering the assembly history of the Milky Way is a formidable task, which becomes possible only if one can produce high-resolution chrono-chemo-kinematical maps of the Galaxy. Data from large-scale astrometric and spectroscopic surveys will soon provide us with a well-defined view of the current chemo-kinematical structure of the Milky Way, but it will only enable a blurred view on the tempora
Life-long production of blood from hematopoietic stem cells (HSC) is a process of strict modulation. Intrinsic and extrinsic signals govern fate options like self-renewal – a cardinal feature of HSC. Bone morphogenetic proteins (BMP) have an established role in embryonic hematopoiesis, but less is known about its functions in adulthood. Previously, SMAD-mediated BMP signaling has been proven dispe
Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was id
In the current discourse on sustainable consumption, there have been major interventions by the businesses and governments, focusing on changing consumer behavior through greening products and services. However, the problem of consumption is not limited to greening products and environmental impacts, but it is also a social issue. Together with the increasing consumption around the world and mater
Title: Ethical vs unethical minded consumer groups: Effects through the mediation of the Theory of Planned Behaviour on the Intention to Purchase during price promotion periods in the United Kingdom. Date of the Seminar: 4th June 2020 Course: BUSN39 Degree project in Global Marketing Authors: Agathe Dugleux and Puteri Nur Najwa Megat Husni Supervisor: Javier Cenamor Keywords: Consumer behavio
Long-distance migratory animals such as birds and bats have evolved to withstand selection imposed by pathogens across the globe, and pathogen richness is known to be particularly high in tropical regions. Immune genes, so-called Major Histocompatibility Complex (MHC) genes, are highly duplicated in songbirds compared to other vertebrates, and this high MHC diversity has been hypothesised to resul
The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of p-tau205 are foremost related to tau pathology in the later stages of the disease. To investigate if the three p-tau variants are found to the same degree in different tau structures and if their co-localization is affected by the diagnosis and
Energy is among the main driving forces needed for sustainable development. Provision of energy services, from the supply side to transmission/distribution and use, must include management, and good management requires tools. Energy planning is a tool for managing the community energy system through assessing and balancing supply and demand. This thesis explains an approach to energy planning whic
The biosynthesis of chlorophyll has been demonstrated to require an extensive set of enzymes, the initial stages of which are shared with the synthesis of heme. Of these enzymes, the most enigmatic is the Mg-protoporphyrin IX monomethyl ester cyclase (EC 1.14.13.81). This enzyme requires components found associated with the plastid membrane and the plastid soluble fraction. One of the components,
Discover how the master’s programme in Digital Architecture and Emergent Futures combines architecture, technology and creative freedom, through the experience of student Sebastian.Student Sebastian shares how the master’s programme in Digital Architecture and Emergent Futures encourages creative freedom and new ways of thinking through technology.
