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Chronic breathlessness occurs across many different conditions, often independently of disease severity. Yet, despite being strongly linked to adverse outcomes, the consideration of chronic breathlessness as a stand-alone therapeutic target remains limited. Here we use data-driven techniques to identify and confirm the stability of underlying features (factors) driving breathlessness across differ
Exact cover is a non-deterministic polynomial time (NP)-complete problem that is central to optimization challenges such as airline fleet planning and allocation of cloud computing resources. Solving exact cover requires the exploration of a solution space that increases exponentially with cardinality. Hence, it is time- and energy consuming to solve large instances of exact cover by serial comput
We investigate the next-to-leading-colour (NLC) contributions to the colour matrix in the fundamental and the colour-flow decompositions for tree-level processes with all gluons, one quark pair and two quark pairs. By analytical examination of the colour factors, we find the non-zero elements in the colour matrix at NLC. At this colour order, together with the symmetry of the phase-space, it is re
Reducing vulnerability is essential for adaptation to climate change. Compared to approaches that examine vulnerability to a specific hazard, our analysis offers an alternative perspective that conceptualizes vulnerability to climate change as a phenomenon that is independent of any specific type of hazard but relevant to multiple hazards. Vulnerability is thus a product of structural inequality a
Contrary to what is sometimes assumed, the elderly in the distant past could not always rely on voluntary care. Therefore, some of them had to develop strategies to secure assistance during old age. We focus on towns in the Low Countries, where family ties were weak, and ageing individuals likely had to plan for old age. We show how members of the middling layers of society could use wills and ret
Polyhydroxyalkanoates (PHAs) are considered good candidates in replacing commercial petrochemical plastics in certain applications like single-use packaging since they are biodegradable, biocompatible and share similar properties with conventional plastics. PHA synthase (PhaC) is the key enzyme in PHA biosynthesis. There are four classes of PhaC, namely, class I, class II, class III and class IV,
Today’s communities are characterized by migration, transnationalism, and participation in the global economy, and many also have long local histories of linguistic diversity. Empowering individuals in these contexts means fostering the ability to use and expand their existing linguistic repertoires so they can take advantage of the social and economic opportunities afforded by contemporary life.
Purpose We validate the usefulness of laser-induced autofluorescence for the detection of bladder carcinoma. Materials and Methods We obtained and analyzed fluorescence spectra from 75 patients in whom bladder cancer was suspected. Tissue fluorescence was excited by a nitrogen laser using a quartz optical fiber placed in gentle contact with the area of interest. The laser-induced autofluorescence
AL-Karama dam, the second largest dam in Jordan, was constructed in the Jordan valley area in the year 1979. Currently, the dam holds about 72% of its designed storage capacity with total dissolved solids concentration of 2.2%. The dam water was designed to irrigate 100 km2 of new reclaimed areas and to provide drinking water for more than 30,000 residences. In this work, solar desalination system
Studies of societal exergy use have the common aim of tracing the flow of exergy along society, and are used to gain insights into the efficiency of energy use and linkages to economic growth. However, their methodological approaches vary greatly, with significant impacts on results. Therefore, we make a review of past studies to identify, synthesize and discuss methodological differences, to cont
In pump-probe experiments employing a free-electron laser (FEL) in combination with a synchronized optical femtosecond laser, the arrival-time jitter between the FEL pulse and the optical laser pulse often severely limits the temporal resolution that can be achieved. Here, we present a pump-probe experiment on the UV-induced dissociation of 2,6-difluoroiodobenzene (C6H3F2I) molecules performed at
Fontan palliation patients are at risk for ventricular arrhythmias post-operatively. This study aimed to evaluate whether differences in the spatial QRS-T angle can reliably predict ventricular arrhythmias in patients who had undergone Fontan palliation. A total of 117 patients who had the Fontan palliation and post-Fontan catheterization were included. Ventricular arrhythmias were identified in n
Controlling robots in real-time over a wireless inter- face present fundamental challenges for forthcoming fifth gen- eration wireless networks. Mission critical real-time applications such as telesurgery over the tactile Internet require a commu- nication link that is both ultra-reliable and low-latency, and that simultaneously serving multiple devices and applications. Wireless performance requi
The paper presents the control server, a real-time scheduling mechanism tailored to control and signal processing applications. A control server creates the abstraction of a control task with a specified period and a fixed input-output latency shorter than the period. Individual tasks can be combined into more complex components without loss of their individual guaranteed fixed-latency properties.
