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Prevention is one of four core research areas at the Centre for Alcohol and Drug Research at Aarhus University in Denmark. This paper provides an overview of the prevention research which has been carried out at the Centre since its establishment in the beginning of the 1990s. Based on a review of all past and ongoing preventive research projects at the Centre, the paper suggests this research has
Beam-driven plasma-wakefield acceleration is an acceleration scheme promising accelerating fields of at least two to three orders of magnitude higher than in conventional radiofrequency accelerating structures. The scheme relies on using a charged particle bunch (driver) to drive a non-linear plasma wake, into which a second bunch (witness) can be injected at an appropriate distance behind the fir
Knowing the longitudinal phase space of an electron beam is one of the most important and crucial issues in short-pulses linacs. To achieve this task expensive and rather complicated setups (like transverse deflecting cavities) are usually implemented. The MAX IV linac is a 3GeV accelerator which will be used to inject into two rings and to drive a short pulse facility. Nevertheless, a more deep u
Inflammasomes are cytosolic multiprotein complexes that assemble in response to infectious or noxious stimuli and activate the CASPASE-1 protease. The inflammasome containing the nucleotide binding domain-leucine-rich repeat (NBD-LRR) protein NLRC4 (interleukin-converting enzyme protease-activating factor [IPAF]) responds to the cytosolic presence of bacterial proteins such as flagellin or the inn
Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen dyskinesias in parkinsonian rats; however, unraveling which specific neurosteroid mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, s
Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term
När vi människor försöker röra på oss skickas elektriska impulser genom nervsystemet från hjärnan ner till de muskler som är inblandade i den tilltänkta rörelsen. Att kunna mäta sådana nervimpulser hade varit av värde för en rad tillämpningar—information hade då kunnat överföras direkt från nervsystemet utan att gå via långsamma, mekaniska gränssnitt så som tangentbord och pekskärmar. OlyckligtvisElectrical activity produced by muscles during voluntary movement is a reflection of the firing patterns of relevant motor neurons and, by extension, the latent motor intent driving the movement. Once transduced via electromyography (EMG) and converted into digital form, this activity can be processed to provide an estimate of the original motor intent and is as such a feasible basis for non-invas
Vast amounts of resources extracted through the times are in today’s built environment, with only an estimated 20-30% of building material recycled or reused and the sector accounting for over 35% of the EU’s total waste generation. Buildings are also responsible for 25-40% of all global carbon dioxide emissions. Circular Economy (CE) refers to the better management of resources and waste by closi
Conservation and consistency are fundamental properties of discretizations of systems of hyperbolic conservation laws. Re- cently, these concepts have been extended to the realm of iterative methods by defining locally conservative and flux consistent iterations. In this note, the current status of such iterative methods is summarized. In particular, it has been shown that Krylov subspace methods
One of the greatest challenges to the use of probabilistic reasoning in the assessment of criminal evidence is the ‘problem of the prior’, i.e. the difficulty in establishing an acceptable prior probability of guilt. Even strong supporters of a Bayesian approach have often preferred to ignore priors and focus on the likelihood ratio (LR) of the evidence. But to calculate if the probability of guil
α‐Chymotrypsin‐catalyzed acyl tranfer was studied using three acyl‐group donors (Mal‐l‐Ala‐l‐Ala‐l‐PheOMe, Bz‐l‐TyrOEt and Ac‐l‐TrpOEt; Mal, maleyl; Bz, benzoyl; OMe, methyl ester; OEt, ethyl ester) and a series of amino‐acid amides. Most of the reactions studied can be described by the simplest kinetic model without the nucleophile binding to the acyl‐enzyme. The α‐chymotrypsin‐catalyzed transfer
OBJECTIVE: To describe, explain and give practical suggestions regarding important principles and key methodological challenges in the study design, statistical analysis, and reporting of results from in vivo studies.CONCLUSIONS: Pre-specifying endpoints and analysis, recognizing the common underlying assumption of statistically independent observations, performing sample size calculations, and ad
